Crybb2 crystallin, beta B2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Crybb2provided by RGD
Official Full Name: crystallin, beta B2provided by RGD
Primary source: RGD:2417
See related: Ensembl:ENSRNOG00000050023 AllianceGenome:RGD:2417
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity. Predicted to be a structural constituent of eye lens. Involved in camera-type eye development. Human ortholog(s) of this gene implicated in cataract and cataract 3 multiple types. Orthologous to human CRYBB2 (crystallin beta B2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (49230192..49240116)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (43569747..43579671)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (49577580..49588555)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data are the first to show that axonal regeneration is related to crybb2 movement.
Title: Elongation of axons during regeneration involves retinal crystallin beta b2 (crybb2).

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of eye lens	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of eye lens	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in camera-type eye development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within camera-type eye development	ISO Inferred from Sequence Orthology more info
involved_in lens development in camera-type eye	IBA Inferred from Biological aspect of Ancestor more info
involved_in visual perception	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within visual perception	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: beta-crystallin B2

Names: R.norvegicus CRYBB2 gene (crystallin, beta B2); beta-B2 crystallin; beta-crystallin Bp

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.