Cd44 CD44 molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cd44provided by RGD
Official Full Name: CD44 moleculeprovided by RGD
Primary source: RGD:2307
See related: Ensembl:ENSRNOG00000006094 AllianceGenome:RGD:2307
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CD44A; METAA; RHAMM
Summary: Enables epidermal growth factor receptor binding activity; phosphoprotein binding activity; and protein kinase binding activity. Involved in several processes, including blood vessel maturation; macrophage fusion; and positive regulation of neutrophil apoptotic process. Located in apical plasma membrane; basolateral plasma membrane; and nucleus. Part of protein-containing complex. Biomarker of borna disease and cholestasis. Human ortholog(s) of this gene implicated in breast carcinoma (multiple); carcinoma (multiple); and prostate cancer. Orthologous to human CD44 (CD44 molecule (Indian blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 333.2), Spleen (RPKM 283.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q32

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (109610824..109699776, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (89155850..89244615, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (92695083..92783820, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of CD44 expressed in renal tubules during maladaptive repair in renal fibrogenesis in an allopurinol-induced rat model of chronic kidney disease.
Title: Role of CD44 expressed in renal tubules during maladaptive repair in renal fibrogenesis in an allopurinol-induced rat model of chronic kidney disease.
Involvement of CD44 and MAPK14-mediated ferroptosis in hemorrhagic shock.
Title: Involvement of CD44 and MAPK14-mediated ferroptosis in hemorrhagic shock.
Potential mechanism of TMEM2/CD44 in endoplasmic reticulum stress-induced neuronal apoptosis in a rat model of traumatic brain injury.
Title: Potential mechanism of TMEM2/CD44 in endoplasmic reticulum stress‑induced neuronal apoptosis in a rat model of traumatic brain injury.
Osteopontin mediation of disturbed flow-induced endothelial mesenchymal transition through CD44 is a novel mechanism of neointimal hyperplasia in arteriovenous fistulae for hemodialysis access.
Title: Osteopontin mediation of disturbed flow-induced endothelial mesenchymal transition through CD44 is a novel mechanism of neointimal hyperplasia in arteriovenous fistulae for hemodialysis access.
Frequency of CD44 positive cells in MKN45 cell line after treatment with docetaxel in two and three-dimensional cell cultures.
Title: Frequency of CD44 positive cells in MKN45 cell line after treatment with docetaxel in two and three-dimensional cell cultures.
This study emphasizes the deleterious effects of hyaluronan signaling on blood-brain barrier integrity, and that such disruption occurred through a CD44-dependent pathway.
Title: Hyaluronan impairs the barrier integrity of brain microvascular endothelial cells through a CD44-dependent pathway.
CD44 knockdown decreases calcification in cultured aortic valve interstitial cells.
Title: Knockdown of CD44 expression decreases valve interstitial cell calcification in vitro.
Both pronociceptive and antinociceptive effects of hyaluronan are mediated by activation of signaling pathways downstream CD44, the cognate hyaluronan receptor, in nociceptors
Title: CD44 Signaling Mediates High Molecular Weight Hyaluronan-Induced Antihyperalgesia.
TGF-beta1-mediated hyaluronan/CD44/STAT3 signaling pathway plays a crucial role in the development of atrial fibrosis and atrial fibrillation.
Title: Transforming growth factor-β-mediated CD44/STAT3 signaling contributes to the development of atrial fibrosis and fibrillation.
The findings indicate for the first time that regulation of Rac1 activity is responsible for hyaluronidase and CD44-driven morphological changes of astrocytes.
Title: Cleavage of Hyaluronan and CD44 Adhesion Molecule Regulate Astrocyte Morphology via Rac1 Signalling.

Submit: New GeneRIF Correction See all GeneRIFs (45)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cd44 (e-PCR), detects polymorphism
- UniSTS:526852

Cd44 (e-PCR), detects polymorphism
- UniSTS:525577

Cd44 (e-PCR), detects polymorphism
- UniSTS:525578

RH142186 (e-PCR)
- UniSTS:231436

PMC111028P1 (e-PCR)
- UniSTS:270201

RH94478 (e-PCR)
- UniSTS:119726

Cd44 (e-PCR), detects polymorphism
- UniSTS:275889

RH134771 (e-PCR)
- UniSTS:218049

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cargo receptor activity	ISO Inferred from Sequence Orthology more info
contributes_to cytokine binding	ISO Inferred from Sequence Orthology more info
contributes_to cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info
contributes_to cytokine receptor activity	ISO Inferred from Sequence Orthology more info
enables epidermal growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables hyaluronic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables hyaluronic acid binding	IEA Inferred from Electronic Annotation more info
enables hyaluronic acid binding	ISO Inferred from Sequence Orthology more info
enables phosphoprotein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables type II transforming growth factor beta receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell activation	IEA Inferred from Electronic Annotation more info
involved_in T cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in blood vessel maturation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within branching involved in prostate gland morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cartilage development	IEA Inferred from Electronic Annotation more info
involved_in cartilage development	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fibroblast growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to fibroblast growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hyaluronan catabolic process	IEA Inferred from Electronic Annotation more info
involved_in hyaluronan catabolic process	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in macrophage fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monocyte aggregation	IEA Inferred from Electronic Annotation more info
involved_in monocyte aggregation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mature B cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of regulatory T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heterotypic cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte aggregation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of monocyte aggregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of lamellipodium morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of lamellipodium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of lamellipodium morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within wound healing involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in wound healing, spreading of cells	IEA Inferred from Electronic Annotation more info
involved_in wound healing, spreading of cells	ISO Inferred from Sequence Orthology more info
involved_in wound healing, spreading of cells	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in cell projection	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in lamellipodium membrane	IEA Inferred from Electronic Annotation more info
located_in lamellipodium membrane	ISO Inferred from Sequence Orthology more info
located_in lamellipodium membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of macrophage migration inhibitory factor receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of macrophage migration inhibitory factor receptor complex	IEA Inferred from Electronic Annotation more info
part_of macrophage migration inhibitory factor receptor complex	ISO Inferred from Sequence Orthology more info
located_in microvillus	IEA Inferred from Electronic Annotation more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in microvillus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CD44 antigen

Names: CD44 molecule (Indian blood group); Cell surface glycoprotein CD44 (hyaluronate binding protein); ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; PGP-1; PGP-I; extracellular matrix receptor III; hermes antigen; hyaluronate receptor; phagocytic glycoprotein 1; phagocytic glycoprotein I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012924.3 → NP_037056.3 CD44 antigen precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6HNQ3, F1LSA1

Related

ENSRNOP00000009000.3, ENSRNOT00000009000.8

Conserved Domains (1) summary

cd03516
Location:29 → 172

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

109610824..109699776 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006234631.5 → XP_006234693.1 CD44 antigen isoform X12

See identical proteins and their annotated locations for XP_006234693.1

UniProtKB/TrEMBL

A0JPL1, A6HNP7, D4A7E6, O70509

Conserved Domains (1) summary

cd03516
Location:29 → 172

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_006234629.5 → XP_006234691.1 CD44 antigen isoform X6

UniProtKB/TrEMBL

A0A8I5ZRQ4, A6HNQ0

Related

ENSRNOP00000080825.1

Conserved Domains (1) summary

cd03516
Location:29 → 172

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_039104369.2 → XP_038960297.1 CD44 antigen isoform X10

UniProtKB/TrEMBL

A6HNP8

Conserved Domains (1) summary

cd03516
Location:29 → 172

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_063283157.1 → XP_063139227.1 CD44 antigen isoform X11
XM_039104367.2 → XP_038960295.1 CD44 antigen isoform X3

UniProtKB/TrEMBL

A0A8I5ZKQ4, A0A8I6GJ35

Related

ENSRNOP00000090715.1

Conserved Domains (1) summary

cd03516
Location:29 → 172

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_008762058.4 → XP_008760280.1 CD44 antigen isoform X9

UniProtKB/TrEMBL

A0A8I6APP8, A6HNQ1

Related

ENSRNOP00000096654.1

Conserved Domains (1) summary

cd03516
Location:29 → 172

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
XM_063283155.1 → XP_063139225.1 CD44 antigen isoform X7
XM_063283153.1 → XP_063139223.1 CD44 antigen isoform X5
XM_063283156.1 → XP_063139226.1 CD44 antigen isoform X8
XM_063283152.1 → XP_063139222.1 CD44 antigen isoform X4
XM_063283151.1 → XP_063139221.1 CD44 antigen isoform X2
XM_006234627.5 → XP_006234689.1 CD44 antigen isoform X1

UniProtKB/TrEMBL

A6HNQ2, D3ZGF1

Related

ENSRNOP00000008760.7

Conserved Domains (1) summary

cd03516
Location:29 → 172

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...