U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RICTOR RPTOR independent companion of MTOR complex 2 [ Homo sapiens (human) ]

Gene ID: 253260, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
RICTORprovided by HGNC
Official Full Name
RPTOR independent companion of MTOR complex 2provided by HGNC
Primary source
HGNC:HGNC:28611
See related
Ensembl:ENSG00000164327 MIM:609022; AllianceGenome:HGNC:28611
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIA; AVO3; hAVO3
Summary
RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 9.8), testis (RPKM 7.0) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
5p13.1
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (38937920..39074399, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (39187325..39323906, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (38938022..39074501, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene OSMR divergent transcript Neighboring gene transmembrane protein 126A pseudogene Neighboring gene Sharpr-MPRA regulatory region 7781 Neighboring gene uncharacterized LOC107986414 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:38810677-38811177 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:38830048-38831247 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:38878837-38879338 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:38879339-38879838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:38908235-38908735 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:38907734-38908234 Neighboring gene NANOG hESC enhancer GRCh37_chr5:38916726-38917255 Neighboring gene oncostatin M receptor Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_84767 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_84768 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:39011967-39012173 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:39073334-39073860 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:39074387-39074913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22495 Neighboring gene androgen induced 1 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 14991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22497 Neighboring gene FYN binding protein 1 Neighboring gene Sharpr-MPRA regulatory region 12253 Neighboring gene golgin A5 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:39220741-39221242 Neighboring gene Sharpr-MPRA regulatory region 14491 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:39242438-39242627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22498 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:39283272-39283436 Neighboring gene complement C9

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Rictor, an essential component of mTOR complex 2, undergoes caspase-mediated cleavage during apoptosis induced by multiple stimuli. Zhao L, et al. Apoptosis, 2021 Jun. PMID 33905036
  2. Rictor promotes tumor progression of rapamycin-insensitive triple-negative breast cancer cells. Watanabe R, et al. Biochem Biophys Res Commun, 2020 Oct 22. PMID 32819718
  3. RICTOR Amplification Promotes NSCLC Cell Proliferation through Formation and Activation of mTORC2 at the Expense of mTORC1. Kim LC, et al. Mol Cancer Res, 2020 Nov. PMID 32801163, Free PMC Article
  4. The role of RICTOR amplification in targeted therapy and drug resistance. Zhao D, et al. Mol Med, 2020 Feb 10. PMID 32041519, Free PMC Article
  5. Correlation between RICTOR overexpression and amplification in advanced solid tumors. Bang H, et al. Pathol Res Pract, 2020 Jan. PMID 31740232

See all (224) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4.
    Title: RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4.
  2. Rictor mediates p53 deactivation to facilitate the malignant transformation of hepatocytes and promote hepatocarcinogenesis.
    Title: Rictor mediates p53 deactivation to facilitate the malignant transformation of hepatocytes and promote hepatocarcinogenesis.
  3. Novel RICTOR amplification harbouring entities: FISH validation of RICTOR amplification in tumour tissue after next-generation sequencing.
    Title: Novel RICTOR amplification harbouring entities: FISH validation of RICTOR amplification in tumour tissue after next-generation sequencing.
  4. UBXN2A suppresses the Rictor-mTORC2 signaling pathway, an established tumorigenic pathway in human colorectal cancer.
    Title: UBXN2A suppresses the Rictor-mTORC2 signaling pathway, an established tumorigenic pathway in human colorectal cancer.
  5. Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.
    Title: Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.
  6. Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt.
    Title: Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt.
  7. Epithelial-mesenchymal reprogramming by KLF4-regulated Rictor expression contributes to metastasis of non-small cell lung cancer cells.
    Title: Epithelial-mesenchymal reprogramming by KLF4-regulated Rictor expression contributes to metastasis of non-small cell lung cancer cells.
  8. LncRNA KCNQ1OT1 promotes osteogenic differentiation via miR-205-5p/RICTOR axis.
    Title: LncRNA KCNQ1OT1 promotes osteogenic differentiation via miR-205-5p/RICTOR axis.
  9. Rictor promotes cell migration and actin polymerization through regulating ABLIM1 phosphorylation in Hepatocellular Carcinoma.
    Title: Rictor promotes cell migration and actin polymerization through regulating ABLIM1 phosphorylation in Hepatocellular Carcinoma.
  10. An RNA-RNA crosstalk network involving HMGB1 and RICTOR facilitates hepatocellular carcinoma tumorigenesis by promoting glutamine metabolism and impedes immunotherapy by PD-L1+ exosomes activity.
    Title: An RNA-RNA crosstalk network involving HMGB1 and RICTOR facilitates hepatocellular carcinoma tumorigenesis by promoting glutamine metabolism and impedes immunotherapy by PD-L1+ exosomes activity.
Submit: New GeneRIF Correction See all GeneRIFs (105)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • KIAA1999, MGC39830, DKFZp686B11164

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in TORC2 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in TORC2 signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to nutrient levels NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cytoskeleton organization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of apoptotic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell growth NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of establishment of cell polarity IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IC
Inferred by Curator
more info
 PubMed 
part_of TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of TORC2 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

Go to the top of the page Help
Preferred Names
rapamycin-insensitive companion of mTOR
Names
AVO3 homolog
TORC2-specific protein AVO3
pianissimo

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285439.2 → NP_001272368.1  rapamycin-insensitive companion of mTOR isoform 2

    See identical proteins and their annotated locations for NP_001272368.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an additional in-frame coding exon compared to variant 1. The resulting longer isoform (2) has an internal protein segment not found in isoform 1.
    Source sequence(s)
    AC008964, AC026713, AC109467
    Consensus CDS
    CCDS68861.1
    UniProtKB/Swiss-Prot
    Q6R327
    Related
    ENSP00000296782.5, ENST00000296782.10
    Conserved Domains (5) summary
    pfam14663
    Location:747 → 853
    RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
    pfam14664
    Location:60 → 437
    RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
    pfam14665
    Location:1084 → 1188
    RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
    pfam14666
    Location:525 → 740
    RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
    pfam14668
    Location:922 → 989
    RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

  2. NM_001285440.2 → NP_001272369.1  rapamycin-insensitive companion of mTOR isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses in-frame acceptor splice sites at 2 internal exons compared to variant 1. The resulting isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC008964, AC026713, AC109467
    UniProtKB/Swiss-Prot
    Q6R327
    Conserved Domains (5) summary
    pfam14663
    Location:462 → 568
    RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
    pfam14664
    Location:3 → 152
    RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
    pfam14665
    Location:799 → 903
    RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
    pfam14666
    Location:240 → 455
    RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
    pfam14668
    Location:637 → 704
    RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

  3. NM_152756.5 → NP_689969.2  rapamycin-insensitive companion of mTOR isoform 1

    See identical proteins and their annotated locations for NP_689969.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.
    Source sequence(s)
    AC008964, AC026713, AC109467
    Consensus CDS
    CCDS34148.1
    UniProtKB/Swiss-Prot
    B2RNX0, B7ZMF7, Q68DT5, Q6R327, Q86UB7, Q8N3A0, Q8NCM6
    Related
    ENSP00000349959.3, ENST00000357387.8
    Conserved Domains (5) summary
    pfam14663
    Location:747 → 853
    RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
    pfam14664
    Location:58 → 437
    RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
    pfam14665
    Location:1085 → 1188
    RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
    pfam14666
    Location:637 → 740
    RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
    pfam14668
    Location:922 → 991
    RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    38937920..39074399 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417070.1 → XP_047273026.1  rapamycin-insensitive companion of mTOR isoform X8

  2. XM_017009312.2 → XP_016864801.1  rapamycin-insensitive companion of mTOR isoform X3

    UniProtKB/TrEMBL
    D6R9S6
    Related
    ENSP00000423162.2, ENST00000514735.2

  3. XM_047417069.1 → XP_047273025.1  rapamycin-insensitive companion of mTOR isoform X5

  4. XM_017009311.2 → XP_016864800.1  rapamycin-insensitive companion of mTOR isoform X1

  5. XM_006714463.4 → XP_006714526.1  rapamycin-insensitive companion of mTOR isoform X6

    Conserved Domains (5) summary
    pfam14663
    Location:747 → 853
    RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
    pfam14664
    Location:60 → 437
    RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
    pfam14665
    Location:1084 → 1188
    RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
    pfam14666
    Location:525 → 740
    RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
    pfam14668
    Location:922 → 989
    RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

  6. XM_011514005.3 → XP_011512307.1  rapamycin-insensitive companion of mTOR isoform X2

    UniProtKB/TrEMBL
    A0AA34QVX7
    Related
    ENSP00000518562.1, ENST00000711063.1
    Conserved Domains (5) summary
    pfam14663
    Location:747 → 853
    RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
    pfam14664
    Location:60 → 437
    RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
    pfam14665
    Location:1084 → 1188
    RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
    pfam14666
    Location:525 → 740
    RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
    pfam14668
    Location:922 → 989
    RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

  7. XM_047417068.1 → XP_047273024.1  rapamycin-insensitive companion of mTOR isoform X4

  8. XM_011514006.4 → XP_011512308.1  rapamycin-insensitive companion of mTOR isoform X7

    Conserved Domains (5) summary
    pfam14663
    Location:684 → 790
    RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
    pfam14664
    Location:2 → 374
    RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
    pfam14665
    Location:1021 → 1125
    RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
    pfam14666
    Location:462 → 677
    RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
    pfam14668
    Location:859 → 926
    RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    39187325..39323906 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352286.1 → XP_054208261.1  rapamycin-insensitive companion of mTOR isoform X8

  2. XM_054352281.1 → XP_054208256.1  rapamycin-insensitive companion of mTOR isoform X3

    UniProtKB/TrEMBL
    D6R9S6

  3. XM_054352283.1 → XP_054208258.1  rapamycin-insensitive companion of mTOR isoform X5

  4. XM_054352279.1 → XP_054208254.1  rapamycin-insensitive companion of mTOR isoform X1

  5. XM_054352284.1 → XP_054208259.1  rapamycin-insensitive companion of mTOR isoform X6

  6. XM_054352280.1 → XP_054208255.1  rapamycin-insensitive companion of mTOR isoform X2

    UniProtKB/TrEMBL
    A0AA34QVX7

  7. XM_054352282.1 → XP_054208257.1  rapamycin-insensitive companion of mTOR isoform X4

  8. XM_054352285.1 → XP_054208260.1  rapamycin-insensitive companion of mTOR isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6R327.1 GenPept UniProtKB/Swiss-Prot:Q6R327

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous