Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hsd17b1provided by RGD
Official Full Name: hydroxysteroid (17-beta) dehydrogenase 1provided by RGD
Primary source: RGD:2836
See related: Ensembl:ENSRNOG00000019830 AllianceGenome:RGD:2836
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: 17BHD1
Summary: Enables estradiol 17-beta-dehydrogenase activity and testosterone dehydrogenase (NAD+) activity. Involved in bone development; cellular response to metal ion; and steroid biosynthetic process. Located in cytosol. Orthologous to human HSD17B1 (hydroxysteroid 17-beta dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 31.2), Uterus (RPKM 23.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (86510011..86512211)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (86009728..86011928)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (88987558..88989758)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gonadal sex steroid hormone secretion after exposure of male rats to estrogenic chemicals and their combinations.
Title: Gonadal sex steroid hormone secretion after exposure of male rats to estrogenic chemicals and their combinations.

Submit: New GeneRIF Correction

General gene information

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Markers

RH142272 (e-PCR)
- UniSTS:231519

D10Wox46 (e-PCR)
- UniSTS:239260

RH134495 (e-PCR)
- UniSTS:217775

Hsd17b1 (e-PCR), detects polymorphism
- UniSTS:267001

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity	ISO Inferred from Sequence Orthology more info
enables NADP binding	ISO Inferred from Sequence Orthology more info
enables NADP+ binding	ISO Inferred from Sequence Orthology more info
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity	IBA Inferred from Biological aspect of Ancestor more info
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity	IDA Inferred from Direct Assay more info	PubMed
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity	ISO Inferred from Sequence Orthology more info
enables estradiol binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables small molecule binding	ISO Inferred from Sequence Orthology more info
enables steroid binding	ISO Inferred from Sequence Orthology more info
enables testosterone dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables testosterone dehydrogenase [NAD(P)] activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adipose tissue development	ISO Inferred from Sequence Orthology more info
involved_in bone development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to metal ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in estrogen biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in estrogen biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in estrogen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in estrogen biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lysosome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in testosterone biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in testosterone biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: estradiol 17-beta-dehydrogenase 1

Names: 17-beta-HSD 1; 17-beta-hydroxysteroid dehydrogenase type 1; Hydroxysteroid dehydrogenase 17 beta, type 1

NP_036983.1

EC 1.1.1.62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.