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Anxa3 annexin A3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25291, updated on 4-Jan-2025

Summary

Official Symbol
Anxa3provided by RGD
Official Full Name
annexin A3provided by RGD
Primary source
RGD:2119
See related
EnsemblRapid:ENSRNOG00000002045 AllianceGenome:RGD:2119
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
LC3; Anx3; LRRGT00047
Summary
Enables calcium-dependent phospholipid binding activity and phospholipase A2 inhibitor activity. Involved in several processes, including animal organ regeneration; hippocampus development; and response to glucocorticoid. Located in axon; dendrite; and neuronal cell body. Biomarker of glaucoma. Orthologous to human ANXA3 (annexin A3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 447.7), Lung (RPKM 306.2) and 8 other tissues See more
Orthologs
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Genomic context

See Anxa3 in Genome Data Viewer
Location:
14p22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (13031675..13085678, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (12727708..12781717, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (14371921..14426503, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096572 Neighboring gene uncharacterized LOC134481719 Neighboring gene U2 spliceosomal RNA Neighboring gene Fraser extracellular matrix complex subunit 1 Neighboring gene uncharacterized LOC134481720 Neighboring gene uncharacterized LOC103693729

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding  
enables calcium-dependent phospholipid binding  
enables calcium-dependent phospholipid binding PubMed 
enables calcium-dependent phospholipid binding  
enables calcium-dependent phospholipid binding  
enables calcium-dependent protein binding  
enables phosphatidylserine binding  
enables phospholipase A2 inhibitor activity PubMed 
enables phospholipase inhibitor activity  
Component Evidence Code Pubs
located_in axon PubMed 
is_active_in cytoplasm  
located_in cytoplasm  
located_in dendrite PubMed 
located_in membrane  
located_in neuronal cell body PubMed 
is_active_in nucleus  
located_in phagocytic vesicle membrane  
is_active_in plasma membrane  
located_in plasma membrane  
located_in specific granule  
is_active_in vesicle membrane  

General protein information

Preferred Names
annexin A3
Names
35-alpha calcimedin
Annexin III (Lipocortin III)
PAP-III
annexin-3
lipocortin III
placental anticoagulant protein III
NP_036955.2
XP_006250758.1
XP_038947560.1
XP_063128938.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012823.2NP_036955.2  annexin A3

    See identical proteins and their annotated locations for NP_036955.2

    Status: VALIDATED

    Source sequence(s)
    BC081856, JAXUCZ010000014
    UniProtKB/Swiss-Prot
    P14669, Q642C2
    UniProtKB/TrEMBL
    A0A8I6A4M3, A6K668, A6K669
    Related
    ENSRNOP00000063496.3, ENSRNOT00000068134.5
    Conserved Domains (1) summary
    pfam00191
    Location:95160
    Annexin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    13031675..13085678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250696.5XP_006250758.1  annexin A3 isoform X1

    See identical proteins and their annotated locations for XP_006250758.1

    UniProtKB/Swiss-Prot
    P14669, Q642C2
    UniProtKB/TrEMBL
    A0A8I6A4M3, A6K668, A6K669
    Conserved Domains (1) summary
    pfam00191
    Location:95160
    Annexin
  2. XM_039091632.2XP_038947560.1  annexin A3 isoform X1

    UniProtKB/Swiss-Prot
    P14669, Q642C2
    UniProtKB/TrEMBL
    A0A8I6A4M3, A6K668, A6K669
    Conserved Domains (1) summary
    pfam00191
    Location:95160
    Annexin
  3. XM_063272868.1XP_063128938.1  annexin A3 isoform X1

    UniProtKB/Swiss-Prot
    P14669, Q642C2
    UniProtKB/TrEMBL
    A0A8I6A4M3, A6K668, A6K669
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