Acadl acyl-CoA dehydrogenase, long chain [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acadlprovided by RGD
Official Full Name: acyl-CoA dehydrogenase, long chainprovided by RGD
Primary source: RGD:2011
See related: Ensembl:ENSRNOG00000012966 AllianceGenome:RGD:2011
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: LCAD; ACOADA
Summary: Enables identical protein binding activity; long-chain-acyl-CoA dehydrogenase activity; and nucleotide binding activity. Involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase and long-chain fatty acid catabolic process. Located in mitochondrial matrix and mitochondrial membrane. Orthologous to human ACADL (acyl-CoA dehydrogenase long chain). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 1009.8), Adrenal (RPKM 481.5) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q32

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (75783689..75822077, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (68333981..68372149, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (73833368..73871857, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW530440 (e-PCR)
- UniSTS:244523

RH142293 (e-PCR)
- UniSTS:231540

ACADL (e-PCR)
- UniSTS:105159

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fatty-acyl-CoA binding	IDA Inferred from Direct Assay more info	PubMed
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IDA Inferred from Direct Assay more info	PubMed
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables long-chain fatty acyl-CoA dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acyl-CoA dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables long-chain fatty acyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acyl-CoA dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables palmitoyl-CoA oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables palmitoyl-CoA oxidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in carnitine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in carnitine metabolic process, CoA-linked	IBA Inferred from Biological aspect of Ancestor more info
involved_in carnitine metabolic process, CoA-linked	ISO Inferred from Sequence Orthology more info
involved_in cellular lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in long-chain fatty acid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fatty acid oxidation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to cold	ISO Inferred from Sequence Orthology more info
involved_in temperature homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: long-chain specific acyl-CoA dehydrogenase, mitochondrial

Names: Acyl Coenzyme A dehydrogenase, long chain; LCAD long chain acyl-CoA dehydrogenase; acetyl-Coenzyme A dehydrogenase, long-chain; acyl-Coenzyme A dehydrogenase, long-chain; long-chain acyl-CoA dehydrogenase

NP_036951.1

EC 1.3.8.8

XP_063122738.1

EC 1.3.8.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012819.3 → NP_036951.1 long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

See identical proteins and their annotated locations for NP_036951.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

P15650

UniProtKB/TrEMBL

A0A8I6GMH0, A6KFD6

Related

ENSRNOP00000017686.4, ENSRNOT00000017686.8

Conserved Domains (2) summary

cd01160
Location:56 → 427

LCAD; Long chain acyl-CoA dehydrogenase

COG1960
Location:53 → 427

CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]