Proc protein C, inactivator of coagulation factors Va and VIIIa [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Procprovided by RGD
Official Full Name: protein C, inactivator of coagulation factors Va and VIIIaprovided by RGD
Primary source: RGD:3411
See related: Ensembl:ENSRNOG00000014376 AllianceGenome:RGD:3411
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables oligopeptidase activity and protein self-association. Involved in liver development; negative regulation of blood coagulation; and proteolysis. Located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; artery disease (multiple); placental abruption; thrombophilia (multiple); and toxic shock syndrome. Orthologous to human PROC (protein C, inactivator of coagulation factors Va and VIIIa). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 1373.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 18p12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (24038596..24049061, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (23764367..23774816, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (24918402..24928822, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vascular endothelial damage in Lipopolysaccharide-induced sepsis model is attenuated by activated protein C.
Title: The effect of plasma-derived activated protein C on leukocyte cell-death and vascular endothelial damage.
APC treatment significantly improves pial microcirculation by reducing leukocyte adhesion and increasing functional capillary density
Title: Activated protein C improves pial microcirculation in experimental endotoxemia in rats.
mutated Protein C did not appear to alter the levels of NFkB or fibrinogen in our model of hemorrhagic shock and resuscitation.
Title: Effect of protein C gene mutation on coagulation and inflammation in hemorrhagic shock.
Xuebijing could upregulate EPCR and PAR1 mRNA and protein expression of rat aortic endothelial cells after LPS challenge.
Title: [Effect of Xuebijing injection on expression of endothelial protein C receptor and protease activated receptor 1 mRNA and protein in endothelial cells induced by lipopolysaccharide].
activated protein C induces the reduction of the nuclear level of NF-kappaB p65 in hippocampal neurons at glutamate-induced excitotoxicity via binding to EPCR and subsequent PAR-1 activation and signaling
Title: Activated protein C prevents glutamate- and thrombin-induced activation of nuclear factor-kappaB in cultured hippocampal neurons.
Activated protein C is a promising therapeutic option for hepatic ischaemia-reperfusion injury.
Title: Activated protein C prevents hepatic ischaemia-reperfusion injury in rats.
although PAR-1 agonism is solely responsible for APC-mediated improvement in systemic hemodynamics, both functions of APC play distinct roles in attenuating the response to injury in the kidney
Title: Distinct functions of activated protein C differentially attenuate acute kidney injury.
NO generated immediately after isoflurane exposure triggers downstream activation of NF-kappaB, resulting in subsequent upregulation of iNOS expression and NO synthesis that mediate APC-induced delayed cardioprotection
Title: Nitric oxide triggers delayed anesthetic preconditioning-induced cardiac protection via activation of nuclear factor-kappaB and upregulation of inducible nitric oxide synthase.
APC at low concentrations, activating PAR1, prevents the death of hippocampal and cortical neurons under conditions of glutamate excitotoxicity.
Title: Activated protein C via PAR1 receptor regulates survival of neurons under conditions of glutamate excitotoxicity.
Low levels of protein C (PC) predict outcome as early as 10 hr after insult in a rat polymicrobial sepsis model and are associated with suppression of PC mRNA.
Title: FoxA2 involvement in suppression of protein C, an outcome predictor in experimental sepsis.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables oligopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within liver development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood coagulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of blood coagulation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of coagulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of coagulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of coagulation	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of establishment of endothelial barrier	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of establishment of endothelial barrier	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of circulating fibrinogen levels	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: vitamin K-dependent protein C

Names: anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV

NP_036935.1

EC 3.4.21.69

XP_006254589.1

EC 3.4.21.69

XP_008770240.3

EC 3.4.21.69

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012803.1 → NP_036935.1 vitamin K-dependent protein C precursor

See identical proteins and their annotated locations for NP_036935.1

Status: PROVISIONAL

Source sequence(s)

X64336

UniProtKB/Swiss-Prot

P31394

UniProtKB/TrEMBL

A6J2Q1

Conserved Domains (5) summary

smart00020
Location:212 → 445

Tryp_SPc; Trypsin-like serine protease

smart00069
Location:26 → 86

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

cd00054
Location:87 → 131

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00190
Location:213 → 447

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam14670
Location:139 → 174

FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

24038596..24049061 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006254527.4 → XP_006254589.1 vitamin K-dependent protein C isoform X2

See identical proteins and their annotated locations for XP_006254589.1

UniProtKB/TrEMBL

A6J2Q1, Q68FY8

Conserved Domains (4) summary

smart00069
Location:26 → 86

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

cd00054
Location:87 → 131

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00190
Location:213 → 447

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam14670
Location:139 → 174

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_008772018.4 → XP_008770240.3 vitamin K-dependent protein C isoform X1

UniProtKB/TrEMBL

A6J2Q1, F7FMY6

Related

ENSRNOP00000019596.4

Conserved Domains (4) summary

smart00069
Location:65 → 125

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

cd00054
Location:126 → 170

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00190
Location:252 → 486

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam14670
Location:178 → 213

FXa_inhibition; Coagulation Factor Xa inhibitory site