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Nmbr neuromedin B receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 25264, updated on 11-Apr-2024

Summary

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Symbol
Nmbrprovided by RGD
Full Name
neuromedin B receptorprovided by RGD
Primary source
RGD:3181
See related
Ensembl:ENSRNOG00000012103 AllianceGenome:RGD:3181
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
NMB-R
Summary
Enables neuropeptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in cytosol and plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human NMBR (neuromedin B receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 15.9), Kidney (RPKM 5.6) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1p13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (10942476..10966174)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (9115033..9146081)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (8933744..8945850)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103690921 Neighboring gene vesicle trafficking 1 Neighboring gene gap junction protein, epsilon 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC102552144

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. cDNA cloning, characterization, and brain region-specific expression of a neuromedin-B-preferring bombesin receptor. Wada E, et al. Neuron, 1991 Mar. PMID 1848080
  2. Molecular cloning and characterization of receptors for the mammalian bombesin-like peptides. Giladi E, et al. J Mol Neurosci, 1993 Spring. PMID 8391296
  3. The peptidergic control circuit for sighing. Li P, et al. Nature, 2016 Feb 18. PMID 26855425, Free PMC Article
  4. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, et al. Genome Res, 2004 Apr. PMID 15060019, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables bombesin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables neuropeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropeptide receptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in antiviral innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in bombesin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-6 production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interferon-alpha production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of osteoclast proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of osteoclast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of respiratory gaseous exchange ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of respiratory gaseous exchange ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sneeze reflex ISO
Inferred from Sequence Orthology
more info
  
involved_in sneeze reflex ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
neuromedin-B receptor
Names
neuromedin-B-preferring bombesin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012799.2 → NP_036931.1  neuromedin-B receptor

    See identical proteins and their annotated locations for NP_036931.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P24053
    UniProtKB/TrEMBL
    A6JP76
    Related
    ENSRNOP00000016215.6, ENSRNOT00000016215.7
    Conserved Domains (2) summary
    cd14964
    Location:45 → 71
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:44 → 335
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    10942476..10966174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101531.2 → XP_038957459.1  neuromedin-B receptor isoform X1

    UniProtKB/Swiss-Prot
    P24053
    UniProtKB/TrEMBL
    A6JP76
    Conserved Domains (2) summary
    cd14964
    Location:45 → 71
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:44 → 335
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_063281563.1 → XP_063137633.1  neuromedin-B receptor isoform X1

    UniProtKB/Swiss-Prot
    P24053
    UniProtKB/TrEMBL
    A6JP76
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P24053.1 GenPept UniProtKB/Swiss-Prot:P24053

Gene LinkOut

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Chemical Information
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Research Materials
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