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Gstt1 glutathione S-transferase theta 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25260, updated on 5-Mar-2024

Summary

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Official Symbol
Gstt1provided by RGD
Official Full Name
glutathione S-transferase theta 1provided by RGD
Primary source
RGD:2765
See related
Ensembl:ENSRNOG00000049771 AllianceGenome:RGD:2765
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GSTYRS
Summary
Enables alkylhalidase activity; glutathione peroxidase activity; and glutathione transferase activity. Involved in several processes, including dichloromethane metabolic process; response to selenium ion; and response to vitamin E. Located in cytosol and nucleus. Biomarker of obesity and type 1 diabetes mellitus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 168.6), Kidney (RPKM 153.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
20p12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (12856068..12873020)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (12856613..12873586)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (13799102..13816527)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S28, pseudogene 4 Neighboring gene glutathione S-transferase, theta 4 Neighboring gene uncharacterized LOC134483890 Neighboring gene glutathione S-transferase, theta 3 Neighboring gene D-dopachrome tautomerase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Inability of GSTT1 to activate iodinated halomethanes to mutagens in Salmonella. DeMarini DM, et al. Environ Mol Mutagen, 2021 Mar. PMID 33484035, Free PMC Article
  2. Diet-induced obese alters the expression and function of hepatic drug-metabolizing enzymes and transporters in rats. Zhang L, et al. Biochem Pharmacol, 2019 Jun. PMID 31063713
  3. Inheritance and Myelodysplasia progression. Giannouli S, et al. Leuk Res, 2013 Oct. PMID 23859717
  4. Are glutathione S-transferase polymorphisms (GSTM1, GSTT1) associated with primary open angle glaucoma? A meta-analysis. Lu Y, et al. Gene, 2013 Sep 15. PMID 23827458
  5. Association study of multiple gene polymorphisms with the risk of adult-onset primary open-angle glaucoma in a Mexican population. Buentello-Volante B, et al. Exp Eye Res, 2013 Feb. PMID 23206929

See all (172) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inability of GSTT1 to activate iodinated halomethanes to mutagens in Salmonella.
    Title: Inability of GSTT1 to activate iodinated halomethanes to mutagens in Salmonella.
  2. Functional divergence between human and rat Theta class GST demonstrates that a single point mutation can enable or suppress enzyme activities with different substrates.
    Title: Residue 234 is a master switch of the alternative-substrate activity profile of human and rodent theta class glutathione transferase T1-1.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alkylhalidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione peroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA modification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in dichloromethane metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to salicylic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to selenium ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to vitamin E IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glutathione S-transferase theta-1
Names
GST 5-5
GST class-theta-1
Glutathione S-transferase 1 (theta)
glutathione S-transferase 5
NP_445745.1
XP_008771081.2
XP_008771082.1
XP_008771083.1
XP_038954369.1
XP_038954370.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053293.2 → NP_445745.1  glutathione S-transferase theta-1

    See identical proteins and their annotated locations for NP_445745.1

    Status: PROVISIONAL

    Source sequence(s)
    BC086426
    UniProtKB/Swiss-Prot
    Q01579
    UniProtKB/TrEMBL
    A0A8I6ADD6, B6DYQ8
    Related
    ENSRNOP00000001669.3, ENSRNOT00000001669.5
    Conserved Domains (2) summary
    cd03183
    Location:91 → 217
    GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
    cd03050
    Location:3 → 78
    GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    12856068..12873020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098442.2 → XP_038954370.1  glutathione S-transferase theta-1 isoform X4

    Conserved Domains (2) summary
    cd03050
    Location:3 → 78
    GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...
    cl02776
    Location:91 → 117
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

  2. XM_039098441.2 → XP_038954369.1  glutathione S-transferase theta-1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ADD6
    Conserved Domains (2) summary
    PRK11752
    Location:13 → 59
    PRK11752; putative S-transferase; Provisional
    cd03183
    Location:48 → 174
    GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases

  3. XM_008772859.4 → XP_008771081.2  glutathione S-transferase theta-1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ADD6

  4. XM_008772860.4 → XP_008771082.1  glutathione S-transferase theta-1 isoform X3

    See identical proteins and their annotated locations for XP_008771082.1

    UniProtKB/TrEMBL
    A0A8I6ADD6, A6JKH2
    Related
    ENSRNOP00000090349.1
    Conserved Domains (3) summary
    cd03183
    Location:41 → 167
    GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
    COG0625
    Location:1 → 151
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cl00388
    Location:1 → 28
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  5. XM_008772861.3 → XP_008771083.1  glutathione S-transferase theta-1 isoform X5

    Conserved Domains (1) summary
    cl02776
    Location:1 → 99
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01579.2 GenPept UniProtKB/Swiss-Prot:Q01579

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