Bsg basigin (Ok blood group) [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bsgprovided by RGD
Official Full Name: basigin (Ok blood group)provided by RGD
Primary source: RGD:2220
See related: Ensembl:ENSRNOG00000008414 AllianceGenome:RGD:2220
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CE9; HT7; 5A11; Ox47R; EMMPRIN; basignin
Summary: Predicted to enable cell-cell adhesion mediator activity; signaling receptor activity; and virus receptor activity. Involved in several processes, including decidualization; embryo implantation; and response to cAMP. Located in membrane raft; mitochondrion; and sarcolemma. Is integral component of plasma membrane. Orthologous to human BSG (basigin (Ok blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 2913.9), Heart (RPKM 2509.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (10643788..10651005, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (9993170..10000387, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (12875536..12882753, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

S-nitrosylation of EMMPRIN influences the migration of HSCs and MMP activity in liver fibrosis.
Title: S-nitrosylation of EMMPRIN influences the migration of HSCs and MMP activity in liver fibrosis.
Knockdown of EMMPRIN (OX47) in MRMT-1 Carcinoma Cells Inhibits Tumor Growth and Decreases Cancer-Induced Bone Destruction and Pain.
Title: Knockdown of EMMPRIN (OX47) in MRMT-1 Carcinoma Cells Inhibits Tumor Growth and Decreases Cancer-Induced Bone Destruction and Pain.
CypB-CD147 Signaling Is Involved in Crosstalk between Cartilage and FLS in Collagen-Induced Arthritis.
Title: CypB-CD147 Signaling Is Involved in Crosstalk between Cartilage and FLS in Collagen-Induced Arthritis.
Inflammation suppression by dexamethasone via inhibition of CD147-mediated NF-kappaB pathway in collagen-induced arthritis rats.
Title: Inflammation suppression by dexamethasone via inhibition of CD147-mediated NF-κB pathway in collagen-induced arthritis rats.
This study analyzed the direct interaction between CAIV and the two Monocarboxylate transporters (MCTs) chaperones basigin (CD147) and embigin (GP70). In rat CD147, binding of CAIV was mediated by by the positively charged Lys-73.
Title: Membrane-anchored carbonic anhydrase IV interacts with monocarboxylate transporters via their chaperones CD147 and GP70.
Inhibiting the cyclophilin A-CD147 interaction attenuates aAcute pulmonary embolism -associated RV cardiomyocyte injury and dysfunction by suppressing inflammation.
Title: Inhibition of the cyclophilin A-CD147 interaction attenuates right ventricular injury and dysfunction after acute pulmonary embolism in rats.
EMMPRIN overexpressing subventricular zone neural progenitor cells invade ischemic cortical tissue more efficiently than controls.
Title: EMMPRIN overexpression in SVZ neural progenitor cells increases their migration towards ischemic cortex.
Upregulation of extracellular matrix metalloproteinase inducer (OX47) in rat dorsal root ganglion contributes to the development of mechanical allodynia after nerve injury.
Title: Upregulation of EMMPRIN (OX47) in Rat Dorsal Root Ganglion Contributes to the Development of Mechanical Allodynia after Nerve Injury.
EMMPRIN regulates pressure ulcer healing by controlling the collagen content and angiogenesis rather than MMPs activity.
Title: Local blockage of EMMPRIN impedes pressure ulcers healing in a rat model.
EMMPRIN expression was increased following fluid percussion injury. EMMPRIN increased expression was temporally correlated with an increase in MMP-9 levels. CD147 and MMP-9 may play a role in vascular injuries after TBI.
Title: Increased CD147 (EMMPRIN) expression in the rat brain following traumatic brain injury.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mannose binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables virus receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in decidualization	IEP Inferred from Expression Pattern more info	PubMed
involved_in embryo implantation	IEP Inferred from Expression Pattern more info	PubMed
involved_in endothelial tube morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in endothelial tube morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in neural retina development	ISO Inferred from Sequence Orthology more info
involved_in neural retina development	ISS Inferred from Sequence or Structural Similarity more info
involved_in neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis of dentin-containing tooth	IEP Inferred from Expression Pattern more info	PubMed
involved_in photoreceptor cell maintenance	ISO Inferred from Sequence Orthology more info
involved_in photoreceptor cell maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of matrix metallopeptidase secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of viral entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mercury ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in acrosomal membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in photoreceptor inner segment	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	ISS Inferred from Sequence or Structural Similarity more info
located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info
located_in photoreceptor outer segment	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: basigin

Names: Basigin (Ox47 antigen or CE-9) (EMMPRIN in human) (neurothelin HT7 or 5A11 in avian); Basignin (Ox47 antigen or CE-9) (EMMPRIN in human) (neurothelin HT7 or 5A11 in avian); OX-47 antigen; glycoprotein CE9; neurothelin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109882.1 → NP_001103352.1 basigin isoform 1 precursor

See identical proteins and their annotated locations for NP_001103352.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AY120888, BQ199464, CV119278

UniProtKB/Swiss-Prot

P26453, Q7TNP1

UniProtKB/TrEMBL

A0A8I5ZLB7, A6K8Y4

Related

ENSRNOP00000011275.5, ENSRNOT00000011275.9

Conserved Domains (3) summary

cd00096
Location:40 → 111

Ig; Immunoglobulin domain

smart00410
Location:228 → 321

IG_like; Immunoglobulin like

cl11960
Location:139 → 203

Ig; Immunoglobulin domain
NM_012783.3 → NP_036915.1 basigin isoform 2 precursor

See identical proteins and their annotated locations for NP_036915.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus when compared to isoform 1.

Source sequence(s)

BC059145, BQ199464, CV119278

UniProtKB/TrEMBL

Q6GT74

Related

ENSRNOP00000050252.3, ENSRNOT00000044275.4

Conserved Domains (3) summary

cd00096
Location:122 → 202

Ig; Immunoglobulin domain

smart00410
Location:112 → 205

IG_like; Immunoglobulin like

cl11960
Location:27 → 87

Ig; Immunoglobulin domain