Htr2c 5-hydroxytryptamine receptor 2C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Htr2cprovided by RGD
Official Full Name: 5-hydroxytryptamine receptor 2Cprovided by RGD
Primary source: RGD:2848
See related: Ensembl:ENSRNOG00000030877 AllianceGenome:RGD:2848
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: 5-HT2C; 5HT-1C; 5-HTR2C
Summary: Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in rodents show altered patterns of RNA editing in response to drug treatments and stressful situations. [provided by RefSeq, Jul 2008]
Expression: Restricted expression toward (RPKM 157.0) See more
Orthologs: human mouse all
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Genomic context

Location:: Xq34

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (115453190..115682325)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (110640777..110870288)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (118084520..118318040)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

5-HT2C receptor perturbation has bidirectional influence over instrumental vigour and restraint.
Title: 5-HT(2C) receptor perturbation has bidirectional influence over instrumental vigour and restraint.
Valproate reverses stress-induced somatic hyperalgesia and visceral hypersensitivity by up-regulating spinal 5-HT2C receptor expression in female rats.
Title: Valproate reverses stress-induced somatic hyperalgesia and visceral hypersensitivity by up-regulating spinal 5-HT(2C) receptor expression in female rats.
Serotonin 5-HT2A and 5-HT2C receptors regulate rat maternal behavior through distinct behavioral and neural mechanisms.
Title: Serotonin 5-HT(2A) and 5-HT(2C) receptors regulate rat maternal behavior through distinct behavioral and neural mechanisms.
Our results demonstrate subregion- and layer-specific expression of the 5-HT2AR and 5-HT2CR proteins using immunofluorescence and single recognition PLA, and a spatially close (within 40 nm) interaction between the 5-HT2AR and 5-HT2CR that occurs along a dorsal-ventral gradient in the rat medial prefrontal cortex.
Title: Endogenous Serotonin 5-HT(2A) and 5-HT(2C) Receptors Associate in the Medial Prefrontal Cortex.
This study found that behavioral stimulation of tongue use is associated with an increased 5-HT2C receptor immunostaining in the XII nucleus and an increased c-Fos expression in a subset of 5-HT neurons located in the medullary raphe region most relevant for serotonergic control of XII motoneurons.
Title: Increased tongue use enhances 5-HT(2C) receptor immunostaining in hypoglossal motor nucleus.
Injection of a highly selective 5-HT2C receptor agonist, AR231630, into the ventral tegmental area (VTA) is sufficient to inhibit the expression of amphetamine-induced and basal locomotor activity as well as food intake in rats. Blockade of the anorexic effect of peripheral AR231630 on feeding by intra-VTA 5-HT2C receptor antagonist SB24208 injections suggests the involvement of 5-HT2C receptors in these effects.
Title: 5-HT(2C) receptors in the ventral tegmental area, but not in the arcuate nucleus, mediate the hypophagic and hypolocomotor effects of the selective 5-HT(2C) receptor agonist AR231630 in rats.
This study demonstrated that the proportion of 5-HT2C-R-expressing striatal neurons was 23% (dorsolateral caudate-putamen), 37% (ventromedial caudate-putamen), 53% (nucleus accumbens-core), and 49% (nucleus accumbens-shell).
Title: Expression of Serotonin2C Receptors in Pyramidal and GABAergic Neurons of Rat Prefrontal Cortex: A Comparison with Striatum.
Knockdown of 5-HT2C in the amygdala decreases neuronal activity and inhibits neuropathic-pain-related behaviors.
Title: 5-HT(2C) Receptor Knockdown in the Amygdala Inhibits Neuropathic-Pain-Related Plasticity and Behaviors.
Results demonstrate that the incubation of cue reactivity during prolonged abstinence from cocaine self-administration is associated with lower potency of the selective 5-HT2CR agonist WAY163909 to suppress cue reactivity, with no evident change in agonist efficacy
Title: Incubation of cocaine cue reactivity associates with neuroadaptations in the cortical serotonin (5-HT) 5-HT2C receptor (5-HT2CR) system.
These findings reveal a 5-hydroxytryptamine-mediated mechanism underlying the programming of susceptibility to obesity.
Title: 5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats.

Submit: New GeneRIF Correction See all GeneRIFs (83)

General gene information

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Markers

RH94622 (e-PCR)
- UniSTS:119870

DXRat66 (e-PCR), detects polymorphism
- UniSTS:119217

BF399131 (e-PCR)
- UniSTS:247539

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled serotonin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled serotonin receptor activity	ISO Inferred from Sequence Orthology more info
enables Gq/11-coupled serotonin receptor activity	ISO Inferred from Sequence Orthology more info
enables Gq/11-coupled serotonin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serotonin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS Traceable Author Statement more info	PubMed
involved_in G protein-coupled serotonin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in behavioral fear response	ISO Inferred from Sequence Orthology more info
involved_in behavioral fear response	ISS Inferred from Sequence or Structural Similarity more info
involved_in behavioral response to nicotine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in feeding behavior	IEA Inferred from Electronic Annotation more info
involved_in feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in locomotory behavior	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of dopamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipase C-activating serotonin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating serotonin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipase C-activating serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase D-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of acetylcholine secretion, neurotransmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gamma-aminobutyric acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of appetite	ISO Inferred from Sequence Orthology more info
involved_in regulation of appetite	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of corticotropin-releasing hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of corticotropin-releasing hormone secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of nervous system process	ISO Inferred from Sequence Orthology more info
involved_in regulation of nervous system process	ISS Inferred from Sequence or Structural Similarity more info
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info
involved_in release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensitization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serotonin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of G protein-coupled serotonin receptor complex	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 2C

Names: 5-HT-1C; 5-HT1C; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled; 5-hydroxytryptamine receptor 1C; serotonin 1c receptor; serotonin receptor 2C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012765.3 → NP_036897.2 5-hydroxytryptamine receptor 2C precursor

See identical proteins and their annotated locations for NP_036897.2

Status: REVIEWED

Source sequence(s)

BF285550, BF409467, BF415855, CB557712, CB613191, CB784937, JAXUCZ010000021, U35315

UniProtKB/Swiss-Prot

P08909

UniProtKB/TrEMBL

F1LPS1

Related

ENSRNOP00000060345.3, ENSRNOT00000065293.3

Conserved Domains (2) summary

pfam00001
Location:71 → 370

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:64 → 248

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

115453190..115682325

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099497.2 → XP_038955425.2 5-hydroxytryptamine receptor 2C isoform X2
XM_063279820.1 → XP_063135890.1 5-hydroxytryptamine receptor 2C isoform X1

UniProtKB/TrEMBL

Q62842