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Vav1 vav guanine nucleotide exchange factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25156, updated on 5-Mar-2024

Summary

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Official Symbol
Vav1provided by RGD
Official Full Name
vav guanine nucleotide exchange factor 1provided by RGD
Primary source
RGD:3951
See related
Ensembl:ENSRNOG00000050430 AllianceGenome:RGD:3951
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Vav
Summary
Predicted to enable guanyl-nucleotide exchange factor activity; phosphorylation-dependent protein binding activity; and phosphotyrosine residue binding activity. Involved in immune response-regulating cell surface receptor signaling pathway. Predicted to be located in cell-cell junction. Biomarker of endometriosis; hepatocellular carcinoma; lymphopenia; and type 1 diabetes mellitus. Orthologous to human VAV1 (vav guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 181.4), Thymus (RPKM 161.6) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
9q11
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (2248856..2295905)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (2161985..2209951)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (9617551..9675167, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor interactor 10 Neighboring gene SH2 domain containing 3A Neighboring gene adhesion G protein-coupled receptor E1 Neighboring gene heat shock protein family A (Hsp70) member 14, pseudogene 1 Neighboring gene U1 small nuclear ribonucleoprotein C pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. An Epistatic Interaction between Themis1 and Vav1 Modulates Regulatory T Cell Function and Inflammatory Bowel Disease Development. Pedros C, et al. J Immunol, 2015 Aug 15. PMID 26163585
  2. Differential expression of p95vav in primary lymphoid tissue of BB rats congenic for the lymphopenia gene. Bieg S. Autoimmunity, 1999. PMID 10433093
  3. Tyrosine phosphorylation of Vav stimulates IL-6 production in mast cells by a Rac/c-Jun N-terminal kinase-dependent pathway. Song JS, et al. J Immunol, 1999 Jul 15. PMID 10395673
  4. DNA methylation and oncogene expression in methapyrilene-induced rat liver tumors and in treated hepatocytes in culture. Hernandez L, et al. Mol Carcinog, 1991. PMID 2064726
  5. Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs. Margolis B, et al. Nature, 1992 Mar 5. PMID 1531699

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Klf2-Vav1-Rac1 axis promotes axon regeneration after peripheral nerve injury.
    Title: Klf2-Vav1-Rac1 axis promotes axon regeneration after peripheral nerve injury.
  2. these results highlight the importance of the signaling pathway involving epistasis between Themis1 and Vav1 in the control of Treg suppressive function and susceptibility to IBD development.
    Title: An Epistatic Interaction between Themis1 and Vav1 Modulates Regulatory T Cell Function and Inflammatory Bowel Disease Development.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphorylation-dependent protein binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphorylation-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within T cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell development TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in immune response-regulating cell surface receptor signaling pathway IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in neutrophil chemotaxis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in phagocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phagocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of natural killer cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
involved_in reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell size IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in regulation of cell size ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell size ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell-cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
proto-oncogene vav
Names
p95
vav 1 guanine nucleotide exchange factor
vav 1 oncogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012759.2 → NP_036891.2  proto-oncogene vav

    See identical proteins and their annotated locations for NP_036891.2

    Status: VALIDATED

    Source sequence(s)
    BC091160
    UniProtKB/Swiss-Prot
    P54100
    UniProtKB/TrEMBL
    A0A8I5Y9Q8, Q5BK91
    Related
    ENSRNOP00000077767.1, ENSRNOT00000096076.1
    Conserved Domains (8) summary
    cd10405
    Location:663 → 765
    SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
    cd11976
    Location:784 → 837
    SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
    cd11979
    Location:594 → 656
    SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
    cd00160
    Location:195 → 371
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:385 → 508
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam00130
    Location:516 → 564
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00169
    Location:403 → 504
    PH; PH domain
    pfam00307
    Location:2 → 115
    CH; Calponin homology (CH) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    2248856..2295905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266662.1 → XP_063122732.1  proto-oncogene vav isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54100.1 GenPept UniProtKB/Swiss-Prot:P54100

Gene LinkOut

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