Avpr1a arginine vasopressin receptor 1A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Avpr1aprovided by RGD
Official Full Name: arginine vasopressin receptor 1Aprovided by RGD
Primary source: RGD:2185
See related: Ensembl:ENSRNOG00000004400 AllianceGenome:RGD:2185
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: V1a; AVPR; V1aR
Summary: This gene encodes a receptor for arginine vasopressin, a neurohypophyseal hormone involved in diuresis inhibition, smooth muscle contraction, liver glycogenolysis stimulation and regulation of adrenocorticotropic hormone release from the pituitary. This receptor represents one of three G protein-coupled arginine vasopressin receptors which functions through a phosphotidylinositol-calcium second messenger system in vascular and hepatic tissues. [provided by RefSeq, Jul 2008]
Expression: Biased expression in Liver (RPKM 395.2), Kidney (RPKM 31.7) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (59999743..60003667)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (58114306..58118230)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (67341366..67345290, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Paraventricular Nucleus V1a Receptor Knockdown Blunts Neurocardiovascular Responses to Acute Stress in Male Rats after Chronic Mild Unpredictable Stress.
Title: Paraventricular Nucleus V(1a) Receptor Knockdown Blunts Neurocardiovascular Responses to Acute Stress in Male Rats after Chronic Mild Unpredictable Stress.
Vasopressin and v1br gene expression is increased in the hypothalamic pvn of borderline hypertensive rats.
Title: Vasopressin and v1br gene expression is increased in the hypothalamic pvn of borderline hypertensive rats.
Co-Stimulation of Oxytocin and Arginine-Vasopressin Receptors Affect Hypothalamic Neurospheroid Size.
Title: Co-Stimulation of Oxytocin and Arginine-Vasopressin Receptors Affect Hypothalamic Neurospheroid Size.
V1a and V1b vasopressin receptors within the paraventricular nucleus contribute to hypertension in male rats exposed to chronic mild unpredictable stress.
Title: V(1a) and V(1b) vasopressin receptors within the paraventricular nucleus contribute to hypertension in male rats exposed to chronic mild unpredictable stress.
Findings suggest that forebrain oxytocin receptor and vasopressin 1a are down-regulated in response to chronic oxytocin treatment.
Title: Effects of Chronic Oxytocin Administration and Diet Composition on Oxytocin and Vasopressin 1a Receptor Binding in the Rat Brain.
Our findings show that chemosensory cells within carotid bodies (CBs)express V1aRs and that local stimulation of the CB with Vasopressin (AVP)increases ventilation, which is contrary to systemic effects of AVP manifested by decreased ventilation
Title: Vasopressin V1a receptors are present in the carotid body and contribute to the control of breathing in male Sprague-Dawley rats.
data support a role for altered signalling via central Avpr1a in PreNatal Stress-induced sex-dependent changes in social memory.
Title: Sex-Dependent Effects of Prenatal Stress on Social Memory in Rats: A Role for Differential Expression of Central Vasopressin-1a Receptors.
Increased expression of V1aR in hypothalamic paraventricular nucleus influences autonomic cardiovascular regulation and demarcates vulnerability to stress.
Title: Over-expression of V1A receptors in PVN modulates autonomic cardiovascular control.
Vasopression V1a receptor binding density was higher in juveniles than in adults in regions associated with reward and socio-spatial memory and higher in adults than in juveniles in key regions of the social decision-making network and in cortical regions.
Title: Age and sex differences in oxytocin and vasopressin V1a receptor binding densities in the rat brain: focus on the social decision-making network.
Vasopressin V1A receptors mediate the beneficial effects of hypercapnia on microcirculatory oxygenation during sepsis.
Title: Vasopressin V1A receptors mediate the stabilization of intestinal mucosal oxygenation during hypercapnia in septic rats.

Submit: New GeneRIF Correction See all GeneRIFs (56)

General gene information

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Markers

D7Wox36 (e-PCR)
- UniSTS:239383

D7Arb17 (e-PCR)
- UniSTS:239898

D4Mgh5 (e-PCR)
- UniSTS:239902

RH140183 (e-PCR)
- UniSTS:222262

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables V1A vasopressin receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables peptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables vasopressin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables vasopressin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables vasopressin receptor activity	IEA Inferred from Electronic Annotation more info
enables vasopressin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables vasopressin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in calcium-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to water deprivation	IEP Inferred from Expression Pattern more info	PubMed
involved_in grooming behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maternal aggressive behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maternal behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myotube differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of female receptivity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transmission of nerve impulse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular pH reduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glutamate secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glycogen catabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of prostaglandin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of urine volume	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of vasoconstriction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of corticotropin secretion	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of systemic arterial blood pressure by vasopressin	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of systemic arterial blood pressure by vasopressin	ISO Inferred from Sequence Orthology more info
involved_in response to corticosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to inorganic substance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to organic substance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in social behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in social behavior	IEP Inferred from Expression Pattern more info	PubMed
involved_in sperm ejaculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telencephalon development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: vasopressin V1a receptor

Names: antidiuretic hormone receptor 1a; arginine vasopressin receptor V1a; vascular/hepatic-type arginine vasopressin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053019.2 → NP_444178.2 vasopressin V1a receptor

See identical proteins and their annotated locations for NP_444178.2

Status: REVIEWED

Source sequence(s)

U39450

UniProtKB/Swiss-Prot

P30560, Q5M8D1, Q62874, Q9QW18

UniProtKB/TrEMBL

A0A0G2JVF9, A6HQN0

Related

ENSRNOP00000005829.3, ENSRNOT00000005829.6

Conserved Domains (3) summary

pfam00001
Location:68 → 354

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam08983
Location:378 → 424

DUF1856; Domain of unknown function (DUF1856)

cl21561
Location:62 → 189

7tm_4; Olfactory receptor