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Il4r interleukin 4 receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 25084, updated on 11-Apr-2024

Summary

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Official Symbol
Il4rprovided by RGD
Official Full Name
interleukin 4 receptorprovided by RGD
Primary source
RGD:2899
See related
Ensembl:ENSRNOG00000015441 AllianceGenome:RGD:2899
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Il4ra
Summary
Predicted to enable cytokine receptor activity. Involved in several processes, including ovulation; response to estrogen; and response to odorant. Located in extracellular space. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in several diseases, including acne; allergic conjunctivitis; autoimmune disease (multiple); human immunodeficiency virus infectious disease; and renal tuberculosis. Orthologous to human IL4R (interleukin 4 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 136.5), Adrenal (RPKM 114.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q36
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (189545739..189570639)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (180115061..180139981)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (196942343..196967221)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene lysine demethylase 8 Neighboring gene NSE1 homolog, SMC5-SMC6 complex component Neighboring gene uncharacterized LOC103691233 Neighboring gene uncharacterized LOC120097359 Neighboring gene interleukin 21 receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Oxidative stress regulates IL-4 gene expression in mast cells through the reduction of histone deacetylase. Nakamaru Y, et al. Otolaryngol Head Neck Surg, 2015 Jan. PMID 25411311
  2. Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy. Burton OT, et al. Mucosal Immunol, 2013 Jul. PMID 23149659, Free PMC Article
  3. Retrovirus-mediated delivery of an IL-4 receptor antagonist inhibits allergic responses in a murine model of asthma. Wang G, et al. Sci China Life Sci, 2010 Oct. PMID 20953944
  4. Asthma susceptible genes in Chinese population: a meta-analysis. Li X, et al. Respir Res, 2010 Sep 24. PMID 20868478, Free PMC Article
  5. Immunomodulation with IL-4R alpha antisense oligonucleotide prevents respiratory syncytial virus-mediated pulmonary disease. Ripple MJ, et al. J Immunol, 2010 Oct 15. PMID 20861354, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our results suggest that oxidative stress may up-regulate IL-4 gene expression in mast cells via a decrease in HDAC activity.
    Title: Oxidative stress regulates IL-4 gene expression in mast cells through the reduction of histone deacetylase.
  2. In the amygdala significant up-regulation of interleukin-1 receptor 1 (IL1r1), interleukin-4 receptor (IL4r), fibroblast growth factor 13 (FGF13), and cathepsin-H (CtsH) was observed in males in response to the odor of cornnuts only.
    Title: Novel odors affect gene expression for cytokines and proteinases in the rat amygdala and hippocampus.
  3. Data show that IL-4 receptors are functionally competent in pancreatic beta-cells and that they signal via PI3K and JAK/STAT pathways.
    Title: Human and rodent pancreatic beta-cells express IL-4 receptors and IL-4 protects against beta-cell apoptosis by activation of the PI3K and JAK/STAT pathways.
  4. Increased of IL4Ra in glomeruli in induced Minimal change-like nephropathy.
    Title: Overexpression of interleukin-13 induces minimal-change-like nephropathy in rats.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-4 receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-4 receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of T-helper 1 cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of T-helper 2 cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within defense response to protozoan ISO
Inferred from Sequence Orthology
more info
  
involved_in immune response TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within immunoglobulin mediated immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in interleukin-4-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-4-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of T-helper 1 cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of T-helper 2 cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within positive regulation of immunoglobulin production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of macrophage activation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of mast cell degranulation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of myoblast fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in production of molecular mediator involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to estrogen IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to odorant IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
interleukin-4 receptor subunit alpha
Names
IL-4 receptor subunit alpha
IL-4R subunit alpha
IL-4R-alpha
IL-4RA
interleukin 4 receptor, alpha
interleukin-4 receptor alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133380.2 → NP_596871.2  interleukin-4 receptor subunit alpha precursor

    See identical proteins and their annotated locations for NP_596871.2

    Status: VALIDATED

    Source sequence(s)
    AB015747, AW527353, BQ204155
    UniProtKB/Swiss-Prot
    Q63257, Q9R1W8, Q9WTM8
    UniProtKB/TrEMBL
    A0A8L2R7Z3, A6I914
    Related
    ENSRNOP00000020994.2, ENSRNOT00000020994.6
    Conserved Domains (2) summary
    cd00063
    Location:123 → 220
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09238
    Location:32 → 121
    IL4Ra_N; Interleukin-4 receptor alpha chain, N-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    189545739..189570639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230215.5 → XP_006230277.1  interleukin-4 receptor subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_006230277.1

    UniProtKB/Swiss-Prot
    Q63257, Q9R1W8, Q9WTM8
    UniProtKB/TrEMBL
    A0A8L2R7Z3, A6I914
    Conserved Domains (2) summary
    cd00063
    Location:123 → 220
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09238
    Location:32 → 121
    IL4Ra_N; Interleukin-4 receptor alpha chain, N-terminal

  2. XM_006230216.4 → XP_006230278.1  interleukin-4 receptor subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_006230278.1

    UniProtKB/Swiss-Prot
    Q63257, Q9R1W8, Q9WTM8
    UniProtKB/TrEMBL
    A0A8L2R7Z3, A6I914
    Related
    ENSRNOP00000073767.2
    Conserved Domains (2) summary
    cd00063
    Location:123 → 220
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09238
    Location:32 → 121
    IL4Ra_N; Interleukin-4 receptor alpha chain, N-terminal

  3. XM_017588804.3 → XP_017444293.1  interleukin-4 receptor subunit alpha isoform X1

    UniProtKB/Swiss-Prot
    Q63257, Q9R1W8, Q9WTM8
    UniProtKB/TrEMBL
    A0A8L2R7Z3, A6I914
    Conserved Domains (2) summary
    cd00063
    Location:123 → 220
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09238
    Location:32 → 121
    IL4Ra_N; Interleukin-4 receptor alpha chain, N-terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63257.2 GenPept UniProtKB/Swiss-Prot:Q63257

Gene LinkOut

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