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bru2 bruno 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 250811, updated on 10-May-2024

Summary

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Official Symbol
bru2provided by FlyBase
Official Full Name
bruno 2provided by FlyBase
Primary source
FLYBASE:FBgn0262475
Locus tag
Dmel_CG43065
See related
AllianceGenome:FB:FBgn0262475
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
bru-2; Bru-2; CG17008; CG31761; CG31763; CG43065; CG6319; Dm Bru-2; Dmel\CG43065
Old locus tag
Dmel_CG31761; Dmel_CG31763
Summary
Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in mRNA splice site selection; negative regulation of translation; and regulation of alternative mRNA splicing, via spliceosome. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including adult head; anterior endoderm anlage; and germ layer. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human CELF1 (CUGBP Elav-like family member 1) and CELF2 (CUGBP Elav-like family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
33E1-33E3; 2-46 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12344219..12397528)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12344219..12397528)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45283 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Polycystic kidney disease 2 Neighboring gene virus-induced RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila Bruno paralogue Bru-3 specifically binds the EDEN translational repression element. Delaunay J, et al. Nucleic Acids Res, 2004. PMID 15181172, Free PMC Article
  2. BrunoL1 regulates endoderm proliferation through translational enhancement of cyclin A2 mRNA. Horb LD, et al. Dev Biol, 2010 Sep 15. PMID 20633547, Free PMC Article
  3. 5-Hydroxymethylation-associated epigenetic modifiers of Alzheimer's disease modulate Tau-induced neurotoxicity. Bernstein AI, et al. Hum Mol Genet, 2016 Jun 15. PMID 27060332, Free PMC Article
  4. A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator. Good PJ, et al. J Biol Chem, 2000 Sep 15. PMID 10893231
  5. The Genetic Architecture of Natural Variation in Recombination Rate in Drosophila melanogaster. Hunter CM, et al. PLoS Genet, 2016 Apr. PMID 27035832, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA splice site recognition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of translation ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
bruno 2
Names
CG43065-PA
CG43065-PD
CG43065-PE
CG43065-PF
CG43065-PG
CG43065-PH
CG43065-PI
CG43065-PJ
CG43065-PK
CG43065-PL
CG43065-PM
bru2-PA
bru2-PD
bru2-PE
bru2-PF
bru2-PG
bru2-PH
bru2-PI
bru2-PJ
bru2-PK
bru2-PL
bru2-PM
bruno-2
bruno2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    12344219..12397528
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042891.3 → NP_001036356.1  bruno 2, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036356.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E8R3
    Conserved Domains (3) summary
    cd12631
    Location:294 → 375
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12636
    Location:381 → 461
    RRM2_Bruno_like; RNA recognition motif 2 in Drosophila melanogaster Bruno protein and similar proteins
    cl17169
    Location:801 → 892
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_001259071.2 → NP_001246000.1  bruno 2, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246000.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NF06
    Conserved Domains (2) summary
    cd12636
    Location:381 → 461
    RRM2_Bruno_like; RNA recognition motif 2 in Drosophila melanogaster Bruno protein and similar proteins
    cl17169
    Location:294 → 375
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. NM_176025.3 → NP_788039.1  bruno 2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788039.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86BL5
    Related
    FBpp0293399
    Conserved Domains (4) summary
    cd12631
    Location:294 → 375
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12636
    Location:381 → 461
    RRM2_Bruno_like; RNA recognition motif 2 in Drosophila melanogaster Bruno protein and similar proteins
    TIGR01661
    Location:297 → 734
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:645 → 736
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. NM_001273481.1 → NP_001260410.1  bruno 2, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260410.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86BL5
    Conserved Domains (4) summary
    cd12631
    Location:294 → 375
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12636
    Location:381 → 461
    RRM2_Bruno_like; RNA recognition motif 2 in Drosophila melanogaster Bruno protein and similar proteins
    TIGR01661
    Location:297 → 734
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:645 → 736
    RRM_SF; RNA recognition motif (RRM) superfamily

  5. NM_135715.4 → NP_609559.1  bruno 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609559.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K108
    Related
    FBpp0293398
    Conserved Domains (2) summary
    cd12631
    Location:294 → 375
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12636
    Location:381 → 461
    RRM2_Bruno_like; RNA recognition motif 2 in Drosophila melanogaster Bruno protein and similar proteins

  6. NM_001273482.1 → NP_001260411.1  bruno 2, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260411.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E8R3
    Conserved Domains (3) summary
    cd12631
    Location:294 → 375
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12636
    Location:381 → 461
    RRM2_Bruno_like; RNA recognition motif 2 in Drosophila melanogaster Bruno protein and similar proteins
    cl17169
    Location:801 → 892
    RRM_SF; RNA recognition motif (RRM) superfamily

  7. NM_165007.3 → NP_723742.2  bruno 2, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723742.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NF06
    Conserved Domains (2) summary
    cd12636
    Location:381 → 461
    RRM2_Bruno_like; RNA recognition motif 2 in Drosophila melanogaster Bruno protein and similar proteins
    cl17169
    Location:294 → 375
    RRM_SF; RNA recognition motif (RRM) superfamily

  8. NM_001259069.2 → NP_001245998.1  bruno 2, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245998.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9ND73
    Conserved Domains (1) summary
    cl17169
    Location:294 → 332
    RRM_SF; RNA recognition motif (RRM) superfamily

  9. NM_001259070.1 → NP_001245999.1  bruno 2, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245999.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C1C3H9
    Conserved Domains (2) summary
    cd12636
    Location:139 → 219
    RRM2_Bruno_like; RNA recognition motif 2 in Drosophila melanogaster Bruno protein and similar proteins
    cl17169
    Location:559 → 650
    RRM_SF; RNA recognition motif (RRM) superfamily

  10. NM_001259073.1 → NP_001246002.1  bruno 2, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246002.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C1C3H9
    Conserved Domains (2) summary
    cd12636
    Location:139 → 219
    RRM2_Bruno_like; RNA recognition motif 2 in Drosophila melanogaster Bruno protein and similar proteins
    cl17169
    Location:559 → 650
    RRM_SF; RNA recognition motif (RRM) superfamily

  11. NM_001259072.1 → NP_001246001.1  bruno 2, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246001.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B9EQV1, M9NCT8
    Conserved Domains (1) summary
    cl17169
    Location:258 → 349
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C1C3H9 C1C3H9
M9NCT8 M9NCT8
M9ND73 M9ND73
M9NF06 M9NF06
Q0E8R3 Q0E8R3
Q7K108 Q7K108
Q86BL5 Q86BL5

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