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Pgam2 phosphoglycerate mutase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24959, updated on 4-Jan-2025

Summary

Official Symbol
Pgam2provided by RGD
Official Full Name
phosphoglycerate mutase 2provided by RGD
Primary source
RGD:3313
See related
EnsemblRapid:ENSRNOG00000013532 AllianceGenome:RGD:3313
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pgmut; PGAM-M; D14Mgh1
Summary
Enables 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity. Involved in gluconeogenesis; response to mercury ion; and spermatogenesis. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in myoglobinuria. Orthologous to human PGAM2 (phosphoglycerate mutase 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Muscle (RPKM 21121.2) and Heart (RPKM 4038.6) See more
Orthologs
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Genomic context

See Pgam2 in Genome Data Viewer
Location:
14q21
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (84895763..84897874, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (80681796..80683907, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (86045005..86047116, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2D 4 like, pseudogene 2 Neighboring gene drebrin-like Neighboring gene uncharacterized LOC120096651 Neighboring gene DNA polymerase mu

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway  
involved_in canonical glycolysis  
involved_in gluconeogenesis PubMed 
acts_upstream_of_or_within glycolytic process  
involved_in glycolytic process  
involved_in response to mercury ion PubMed 
involved_in spermatogenesis PubMed 
involved_in striated muscle contraction  
Component Evidence Code Pubs
is_active_in cytosol  

General protein information

Preferred Names
phosphoglycerate mutase 2
Names
BPG-dependent PGAM 2
isozyme MM
muscle-specific phosphoglycerate mutase
phosphoglycerate mutase 2 (muscle)
phosphoglycerate mutase isozyme M
type MM phosphoglycerate mutase
NP_059024.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017328.3NP_059024.1  phosphoglycerate mutase 2

    See identical proteins and their annotated locations for NP_059024.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    P16290
    UniProtKB/TrEMBL
    A6IKP6, A6IKP7
    Related
    ENSRNOP00000018227.4, ENSRNOT00000018227.9
    Conserved Domains (1) summary
    TIGR01258
    Location:4251
    pgm_1; phosphoglycerate mutase, BPG-dependent, family 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    84895763..84897874 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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