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Yes1 YES proto-oncogene 1, Src family tyrosine kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 24884, updated on 11-Apr-2024

Summary

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Official Symbol
Yes1provided by RGD
Official Full Name
YES proto-oncogene 1, Src family tyrosine kinaseprovided by RGD
Primary source
RGD:3977
See related
Ensembl:ENSRNOG00000037227 AllianceGenome:RGD:3977
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Yes; c-Yes; p61-Yes; p60c-yes
Summary
Enables epidermal growth factor receptor binding activity and protein tyrosine kinase activity. Involved in protein autophosphorylation. Located in plasma membrane. Is active in glutamatergic synapse and postsynaptic specialization, intracellular component. Orthologous to human YES1 (YES proto-oncogene 1, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 157.1), Kidney (RPKM 134.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
9q38
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (120646657..120753880)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (113200256..113275942)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (121802471..121918906)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 6 Neighboring gene adenylate cyclase activating polypeptide 1 Neighboring gene thymidylate synthetase Neighboring gene clusterin like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. c-Yes regulates cell adhesion at the apical ectoplasmic specialization-blood-testis barrier axis via its effects on protein recruitment and distribution. Xiao X, et al. Am J Physiol Endocrinol Metab, 2013 Jan 15. PMID 23169788, Free PMC Article
  2. The Src kinase Yes is activated in pancreatic acinar cells by gastrointestinal hormones/neurotransmitters, but not pancreatic growth factors, which stimulate its association with numerous other signaling molecules. Sancho V, et al. Biochim Biophys Acta, 2012 Aug. PMID 22617836, Free PMC Article
  3. c-Yes regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization in the seminiferous epithelium of rat testes. Xiao X, et al. Int J Biochem Cell Biol, 2011 Apr. PMID 21256972, Free PMC Article
  4. The tyrosine kinase Yes regulates actin structure and secretion during pancreatic acinar cell damage in rats. Lynch G, et al. Pflugers Arch, 2004 Jan. PMID 14634819
  5. Identification of autophosphorylation sites in c-Yes purified from rat liver plasma membranes. Ariki M, et al. J Biochem, 1997 Jan. PMID 9058199

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. c-Yes was found to promote endocytosed integral membrane blood-testis barrier (BTB) proteins to the pathway of transcytosis and recycling so that internalized proteins could be effectively used to assemble new BTB from the disassembling old BTB.
    Title: Differential effects of c-Src and c-Yes on the endocytic vesicle-mediated trafficking events at the Sertoli cell blood-testis barrier: an in vitro study.
  2. c-Yes regulates cell adhesion at the apical ectoplasmic specialization-blood-testis barrier axis.
    Title: c-Yes regulates cell adhesion at the apical ectoplasmic specialization-blood-testis barrier axis via its effects on protein recruitment and distribution.
  3. In rat pancreatic acini, the SFK member Yes is expressed and activated by CCK and other gastrointestinal hormones/neurotransmitters.
    Title: The Src kinase Yes is activated in pancreatic acinar cells by gastrointestinal hormones/neurotransmitters, but not pancreatic growth factors, which stimulate its association with numerous other signaling molecules.
  4. c-Yes regulates blood-testis barrier and apical ectoplasmic specialization integrity by maintaining proper distribution of integral membrane proteins and actin filament organization at these sites
    Title: c-Yes regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization in the seminiferous epithelium of rat testes.
  5. Hypoxia enhanced phosphorylation of three srcFK proteins at Tyr-416 (60, 59, and 54 kDa, corresponding to src, fyn, and yes, respectively) and enhanced srcFK-dependent tyrosine phosphorylation of multiple target proteins.
    Title: Role of src-family kinases in hypoxic vasoconstriction of rat pulmonary artery.
  6. Yes is activated by cholecystokinin, which stimulates extracellular signal-regulated kinase
    Title: Cholecystokinin stimulates extracellular signal-regulated kinase through activation of the epidermal growth factor receptor, Yes, and protein kinase C. Signal amplification at the level of Raf by activation of protein kinase Cepsilon.
  7. Src family kinase Yes triggers hyperosmotic activation of the epidermal growth factor receptor and CD95
    Title: The Src family kinase Yes triggers hyperosmotic activation of the epidermal growth factor receptor and CD95.
  8. Yes participates in the regulation of acinar cell actin, probably by interaction with Pyk2.
    Title: The tyrosine kinase Yes regulates actin structure and secretion during pancreatic acinar cell damage in rats.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC94936

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables epidermal growth factor receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to platelet-derived growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to retinoic acid ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of glucose transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in actin filament ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
is_active_in postsynaptic specialization, intracellular component IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase Yes
Names
Yamagichi sarcoma viral (v-yes-1) oncogene homolog 1
Yamaguchi sarcoma viral (v-yes) oncogene homolog 1
Yamaguchi sarcoma viral oncogene homolog 1
NP_001385513.1
NP_001385514.1
NP_150640.1
XP_063122722.1
XP_063122723.1
XP_063122724.1
XP_063122725.1
XP_063122726.1
XP_063122727.1
XP_063122728.1
XP_063122729.1
XP_063122730.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398584.1 → NP_001385513.1  tyrosine-protein kinase Yes isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8J8XNH3, A6KFB6, Q99PW1
    Related
    ENSRNOP00000053094.4, ENSRNOT00000056251.6
    Conserved Domains (3) summary
    cd09933
    Location:152 → 251
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:92 → 149
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    cd05069
    Location:262 → 540
    PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes

  2. NM_001398585.1 → NP_001385514.1  tyrosine-protein kinase Yes isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8J8XNH3, A6KFB6, Q99PW1
    Conserved Domains (3) summary
    cd09933
    Location:152 → 251
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:92 → 149
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    cd05069
    Location:262 → 540
    PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes

  3. NM_033298.2 → NP_150640.1  tyrosine-protein kinase Yes isoform 2

    See identical proteins and their annotated locations for NP_150640.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    F1LM93
    UniProtKB/TrEMBL
    F1LM92, Q6AXQ3
    Related
    ENSRNOP00000072395.2, ENSRNOT00000086534.2
    Conserved Domains (4) summary
    cd09933
    Location:152 → 251
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:92 → 149
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    pfam07714
    Location:275 → 474
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:262 → 478
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    120646657..120753880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266654.1 → XP_063122724.1  tyrosine-protein kinase Yes isoform X1

  2. XM_063266657.1 → XP_063122727.1  tyrosine-protein kinase Yes isoform X2

    UniProtKB/TrEMBL
    A0A8J8XNH3, A6KFB6, Q99PW1

  3. XM_063266655.1 → XP_063122725.1  tyrosine-protein kinase Yes isoform X1

  4. XM_063266652.1 → XP_063122722.1  tyrosine-protein kinase Yes isoform X1

  5. XM_063266659.1 → XP_063122729.1  tyrosine-protein kinase Yes isoform X3

  6. XM_063266660.1 → XP_063122730.1  tyrosine-protein kinase Yes isoform X4

  7. XM_063266653.1 → XP_063122723.1  tyrosine-protein kinase Yes isoform X1

  8. XM_063266658.1 → XP_063122728.1  tyrosine-protein kinase Yes isoform X2

    UniProtKB/TrEMBL
    A0A8J8XNH3, A6KFB6, Q99PW1

  9. XM_063266656.1 → XP_063122726.1  tyrosine-protein kinase Yes isoform X1

RNA

  1. XR_010054569.1 RNA Sequence

  2. XR_010054570.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1LM93.1 GenPept UniProtKB/Swiss-Prot:F1LM93

Gene LinkOut

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