Tgfa transforming growth factor alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tgfaprovided by RGD
Official Full Name: transforming growth factor alphaprovided by RGD
Primary source: RGD:3849
See related: Ensembl:ENSRNOG00000016182 AllianceGenome:RGD:3849
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TGFAA; RATTGFAA
Summary: Enables epidermal growth factor receptor binding activity. Involved in several processes, including hepatocyte proliferation; negative regulation of apoptotic process; and wound healing. Located in extracellular space and nucleus. Colocalizes with plasma membrane. Used to study pancreatic cancer. Biomarker of acute kidney failure and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in gastroenteritis. Orthologous to human TGFA (transforming growth factor alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 28.9), Brain (RPKM 26.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (120175549..120258342)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (118618043..118700897)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (117961877..118045923)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transforming Growth Factor-alpha Acts in Hypothalamic Paraventricular Nucleus to Upregulate ERK1/2 Signaling and Expression of Sympathoexcitatory Mediators in Heart Failure Rats.
Title: Transforming Growth Factor-α Acts in Hypothalamic Paraventricular Nucleus to Upregulate ERK1/2 Signaling and Expression of Sympathoexcitatory Mediators in Heart Failure Rats.
5-HT stimulates DNA synthesis and proliferation in primary cultures of adult rat hepatocytes by acting via autocrine secretion of TGF-alpha induced by the serotonin 5-HT2B receptor/Gq/PLC/Ca2+ pathway.
Title: Serotonin 5-HT2B Receptor-Stimulated DNA Synthesis and Proliferation Are Mediated by Autocrine Secretion of Transforming Growth Factor-α in Primary Cultures of Adult Rat Hepatocytes.
Lipopolysaccharide exposure led to a suppression of both HDAC1 and HDAC2 expression and activity, induced TGFa expression, and disrupted alveolar morphology.
Title: Lipopolysaccharide induces up-regulation of TGF-α through HDAC2 in a rat model of bronchopulmonary dysplasia.
mechanical stretch promotes fetal type II cell differentiation via ectodomain shedding of HB-EGF and TGF-alpha
Title: Mechanical stretch promotes fetal type II epithelial cell differentiation via shedding of HB-EGF and TGF-alpha.
study adds TGFalpha to the list of dysregulated cytokines present in degrading cartilage in osteoarthritis
Title: Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis.
TGFalpha-EGFR autocrine ring formation may lead to the activation of Stat3 and in turn, promote proliferation and regulate the transcription of genes regulating cell apoptosis and cell cycle.
Title: Roles of EGFR-Stat3 signal pathway in carcinogenesis of experimental hepatoma in rats.
A novel mechanism for mitogenic signaling via pro-transforming growth factor alpha within hepatocyte nuclei.
Title: A novel mechanism for mitogenic signaling via pro-transforming growth factor alpha within hepatocyte nuclei.
TGFalpha plays an autocrine role in LH dependent development and function of Leydig cells.
Title: Autocrine regulation of steroidogenic function of Leydig cells by transforming growth factor-alpha.
results support the hypothesis that FSH stimulates granulosa cell proliferation via theca TGFalpha secretion
Title: Involvement of transforming growth factor alpha in the regulation of rat ovarian X-linked inhibitor of apoptosis protein expression and follicular growth by follicle-stimulating hormone.
Gastric adaptation to stress injury involves enhanced cell proliferation, increased expression of pS2 and TGFalpha, and reduced expression of COX-2 and iNOS.
Title: Cyclooxygenase 2, pS2, inducible nitric oxide synthase and transforming growth factor alpha in gastric adaptation to stress.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

D4Got90 (e-PCR)
- UniSTS:114185

D4Arb5 (e-PCR)
- UniSTS:142602

D6R4Arb5 (e-PCR), detects polymorphism
- UniSTS:142602

Tgfa (e-PCR), detects polymorphism
- UniSTS:463966

D4Cebr4 (e-PCR)
- UniSTS:518757

AU047195 (e-PCR)
- UniSTS:110747

RH94516 (e-PCR)
- UniSTS:119764

D4Wox18 (e-PCR)
- UniSTS:117976

Tgfa (e-PCR), detects polymorphism
- UniSTS:144607

ABA004 (e-PCR), detects polymorphism
- UniSTS:539113

Tgfa (e-PCR), detects polymorphism
- UniSTS:516088

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables epidermal growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables epidermal growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables epidermal growth factor receptor binding	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables epidermal growth factor receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables epidermal growth factor receptor binding	TAS Traceable Author Statement more info	PubMed
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables growth factor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase activator activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ERBB2-EGFR signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ERBB2-EGFR signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in epidermal growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in epidermal growth factor receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in hepatocyte proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in hepatocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in mammary gland alveolus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mammary gland alveolus development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitotic nuclear division	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mitotic nuclear division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic nuclear division	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protransforming growth factor alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012671.2 → NP_036803.1 protransforming growth factor alpha preproprotein

See identical proteins and their annotated locations for NP_036803.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004, M31076

UniProtKB/Swiss-Prot

P01134, Q63749

UniProtKB/TrEMBL

A6IAV5, A6IAV6

Conserved Domains (2) summary

PHA02887
Location:43 → 82

PHA02887; EGF-like protein; Provisional

PHA03099
Location:46 → 120

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

120175549..120258342

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107070.2 → XP_038962998.1 protransforming growth factor alpha isoform X1

UniProtKB/TrEMBL

A6IAV6

Conserved Domains (2) summary

PHA02887
Location:44 → 83

PHA02887; EGF-like protein; Provisional

PHA03099
Location:47 → 121

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
XM_006236822.5 → XP_006236884.1 protransforming growth factor alpha isoform X3

See identical proteins and their annotated locations for XP_006236884.1

UniProtKB/TrEMBL

A6IAV6, U5LKN7

Conserved Domains (2) summary

PHA02887
Location:43 → 82

PHA02887; EGF-like protein; Provisional

PHA03099
Location:46 → 120

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
XM_039107071.2 → XP_038962999.1 protransforming growth factor alpha isoform X2

UniProtKB/TrEMBL

A0A8L2QQQ8, A6IAV6

Related

ENSRNOP00000054248.3

Conserved Domains (2) summary

PHA02887
Location:44 → 83

PHA02887; EGF-like protein; Provisional

PHA03099
Location:47 → 121

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional