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Sts steroid sulfatase [ Rattus norvegicus (Norway rat) ]

Gene ID: 24800, updated on 13-Apr-2024

Summary

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Official Symbol
Stsprovided by RGD
Official Full Name
steroid sulfataseprovided by RGD
Primary source
RGD:3783
See related
Ensembl:ENSRNOG00000032487 AllianceGenome:RGD:3783
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables steryl-sulfatase activity. Involved in several processes, including response to estrogen; response to pH; and response to peptide hormone. Located in endoplasmic reticulum membrane and nuclear envelope. Is integral component of membrane. Biomarker of cryptorchidism and hypertension. Human ortholog(s) of this gene implicated in X-linked ichthyosis. Orthologous to human STS (steroid sulfatase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 60.7), Adrenal (RPKM 59.0) and 9 other tissues See more
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Genomic context

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Location:
Xq21
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (46102524..46110868)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (42225131..42233403)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (45420418..45428748)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene anomalous homeobox Neighboring gene prostaglandin E synthase 3-like 1 Neighboring gene patatin like phospholipase domain containing 4 Neighboring gene protein tyrosine phosphatase 4A1, pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel steroidal selective steroid sulfatase inhibitor KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells in vitro and in animal models. Ishida H, et al. Breast Cancer Res Treat, 2007 Dec. PMID 17268815
  2. Inhibition of steroid sulphatase activity by tricyclic coumarin sulphamates. Malini B, et al. J Steroid Biochem Mol Biol, 2000 Dec 31. PMID 11282279
  3. The effect of steroid sulfatase inhibition on learning and spatial memory. Johnson DA, et al. Brain Res, 2000 May 26. PMID 10821934
  4. Microsomal steroid sulfatase: interactions with cytosolic steroid sulfotransferases. Kauffman FC, et al. Chem Biol Interact, 1998 Feb 20. PMID 9566744
  5. Epidermal steroid sulfatase and cholesterol sulfotransferase are regulated during late gestation in the fetal rat. Hanley K, et al. J Invest Dermatol, 1997 Jun. PMID 9182813

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables arylsulfatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables steryl-sulfatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sulfuric ester hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in female pregnancy IEA
Inferred from Electronic Annotation
more info
  
involved_in learning or memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to estrogen IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to organic cyclic compound IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to pH IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to peptide hormone IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in skin development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
steryl-sulfatase
Names
ASC
arylsulfatase C
steroid sulfatase (microsomal), isozyme S
steryl-sulfate sulfohydrolase
NP_036793.2
XP_006257023.1
XP_006257024.1
XP_063135863.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012661.2 → NP_036793.2  steryl-sulfatase precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/Swiss-Prot
    P15589
    UniProtKB/TrEMBL
    A6IPT8, G3V9E5
    Related
    ENSRNOP00000043915.3, ENSRNOT00000051897.5
    Conserved Domains (1) summary
    cl23718
    Location:26 → 548
    ALP_like; alkaline phosphatases and sulfatases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    46102524..46110868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256961.5 → XP_006257023.1  steryl-sulfatase isoform X1

    See identical proteins and their annotated locations for XP_006257023.1

    UniProtKB/Swiss-Prot
    P15589
    UniProtKB/TrEMBL
    A6IPT8, G3V9E5
    Conserved Domains (1) summary
    cl23718
    Location:26 → 548
    ALP_like; alkaline phosphatases and sulfatases

  2. XM_006256962.5 → XP_006257024.1  steryl-sulfatase isoform X2

    UniProtKB/Swiss-Prot
    P15589
    Conserved Domains (2) summary
    COG3119
    Location:26 → 415
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cl23718
    Location:26 → 441
    ALP_like; alkaline phosphatases and sulfatases

  3. XM_063279793.1 → XP_063135863.1  steryl-sulfatase isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15589.2 GenPept UniProtKB/Swiss-Prot:P15589

Gene LinkOut

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