Sod2 superoxide dismutase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sod2provided by RGD
Official Full Name: superoxide dismutase 2provided by RGD
Primary source: RGD:3732
See related: Ensembl:ENSRNOG00000019048 AllianceGenome:RGD:3732
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MnSOD
Summary: Enables several functions, including identical protein binding activity; manganese ion binding activity; and superoxide dismutase activity. Involved in several processes, including hydrogen peroxide biosynthetic process; negative regulation of membrane hyperpolarization; and positive regulation of hydrogen peroxide biosynthetic process. Located in mitochondrial nucleoid. Used to study esophagus adenocarcinoma; hypertension; intestinal disease; and myocardial infarction. Biomarker of several diseases, including adult respiratory distress syndrome; artery disease (multiple); bladder neck obstruction; congenital diaphragmatic hernia; and hyperhomocysteinemia. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); lipid storage disease (multiple); liver disease (multiple); and optic nerve disease (multiple). Orthologous to human SOD2 (superoxide dismutase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 2100.6), Heart (RPKM 1328.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (50043323..50050168, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (47638318..47645163, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (47914757..47921587, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hippocampus mitochondrial MnSOD activation by a SIRT3 activator, honokiol, correlates with its deacetylation and upregulation of FoxO3a and PGC1alpha in a rat model of ammonia neurotoxicity.
Title: Hippocampus mitochondrial MnSOD activation by a SIRT3 activator, honokiol, correlates with its deacetylation and upregulation of FoxO3a and PGC1α in a rat model of ammonia neurotoxicity.
[Electroacupuncture preconditioning alleviates renal injury and oxidative stress through Sirt3/MnSOD pathway in type 2 diabetic rats].
Title: [Electroacupuncture preconditioning alleviates renal injury and oxidative stress through Sirt3/MnSOD pathway in type 2 diabetic rats].
SOD2 Alleviates Hearing Loss Induced by Noise and Kanamycin in Mitochondrial DNA4834-deficient Rats by Regulating PI3K/MAPK Signaling.
Title: SOD2 Alleviates Hearing Loss Induced by Noise and Kanamycin in Mitochondrial DNA4834-deficient Rats by Regulating PI3K/MAPK Signaling.
CircSOD2: A Novel Regulator for Smooth Muscle Proliferation and Neointima Formation.
Title: CircSOD2: A Novel Regulator for Smooth Muscle Proliferation and Neointima Formation.
Epigenetic Blockade of Hippocampal SOD2 Via DNMT3b-Mediated DNA Methylation: Implications in Mild Traumatic Brain Injury-Induced Persistent Oxidative Damage.
Title: Epigenetic Blockade of Hippocampal SOD2 Via DNMT3b-Mediated DNA Methylation: Implications in Mild Traumatic Brain Injury-Induced Persistent Oxidative Damage.
AURKA ubiquitination influences mitochondrial dysfunction and suppresses the occurrence of OA via degradation of SOD2.
Title: Effects of AURKA-mediated degradation of SOD2 on mitochondrial dysfunction and cartilage homeostasis in osteoarthritis.
The ischemia/reperfusion (I/R)-induced acute kidney injury (AKI) rat model found that Sirt3 activity was considerably reduced compared to controls and accompanied by increased acetylation of Sod2 and p53 in the mitochondria of renal tubular epithelial cells revealing importance of this event in the pathogenesis of I/R-induced AKI and rising possibility that Sirt3 may be an upstream regulator of both Sod2 and p53.
Title: SIRT3 Inactivation Promotes Acute Kidney Injury Through Elevated Acetylation of SOD2 and p53.
Chronic intermittent hypoxia nitrated MnSOD in the carotid body and adrenal medulla, but its activity decreased in the adrenal gland.
Title: Nitration of MnSOD in the Carotid Body and Adrenal Gland Induced by Chronic Intermittent Hypoxia.
Circulating levels of the 3 miRNAs and their target SOD2 were associated with high left ventricular remodeling post-MI in REVE-2 patients. We demonstrated for the first time the potential of microRNAs regulating SOD2 as new circulating biomarkers of heart failure
Title: MicroRNAs regulating superoxide dismutase 2 are new circulating biomarkers of heart failure.
These results indicate that stress conditions most probably altered the cell redox equilibrium, thus influencing the antioxidant response in brain cortex.
Title: Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress.

Submit: New GeneRIF Correction See all GeneRIFs (58)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH140146 (e-PCR)
- UniSTS:222225

RH94608 (e-PCR)
- UniSTS:119856

RH140197 (e-PCR)
- UniSTS:222276

Sod2 (e-PCR), detects polymorphism
- UniSTS:144478

RH130474 (e-PCR)
- UniSTS:213758

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables manganese ion binding	IDA Inferred from Direct Assay more info	PubMed
enables manganese ion binding	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables oxygen binding	IDA Inferred from Direct Assay more info	PubMed
enables superoxide dismutase activity	IBA Inferred from Biological aspect of Ancestor more info
enables superoxide dismutase activity	IDA Inferred from Direct Assay more info	PubMed
enables superoxide dismutase activity	ISO Inferred from Sequence Orthology more info
enables superoxide dismutase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic mitochondrial changes	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within detection of oxygen	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within erythrophore differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glutathione metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hemopoiesis	ISO Inferred from Sequence Orthology more info
involved_in hydrogen peroxide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in hydrogen peroxide metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular oxygen homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to oxidative stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within liver development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrion organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of membrane hyperpolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hydrogen peroxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of blood pressure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in removal of superoxide radicals	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within removal of superoxide radicals	ISO Inferred from Sequence Orthology more info
involved_in removal of superoxide radicals	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within respiratory electron transport chain	ISO Inferred from Sequence Orthology more info
involved_in response to L-ascorbic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to axon injury	ISO Inferred from Sequence Orthology more info
involved_in response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to electrical stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to gamma radiation	ISO Inferred from Sequence Orthology more info
involved_in response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to hyperoxia	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to immobilization stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to isolation stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to magnetism	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to manganese ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IDA Inferred from Direct Assay more info	PubMed
involved_in response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to oxidative stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in response to selenium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to silicon dioxide	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to superoxide	ISO Inferred from Sequence Orthology more info
involved_in response to superoxide	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in response to zinc ion	IEP Inferred from Expression Pattern more info	PubMed
NOT acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within superoxide anion generation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within superoxide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in superoxide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in superoxide metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial nucleoid	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: superoxide dismutase [Mn], mitochondrial

Names: Superoxide dimutase 2, mitochondrial; manganese superoxide dismutase; mitochondrial superoxide dismutase 2; superoxide dismutase 2, mitochondrial

NP_058747.1

EC 1.15.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017051.2 → NP_058747.1 superoxide dismutase [Mn], mitochondrial precursor

See identical proteins and their annotated locations for NP_058747.1

Status: PROVISIONAL

Source sequence(s)

BC070913

UniProtKB/Swiss-Prot

P07895

UniProtKB/TrEMBL

A6KP26

Related

ENSRNOP00000025794.3, ENSRNOT00000025794.5

Conserved Domains (1) summary

COG0605
Location:25 → 217

SodA; Superoxide dismutase [Inorganic ion transport and metabolism]