Sod1 superoxide dismutase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24786, updated on 11-Apr-2024

Summary

Official Symbol: Sod1provided by RGD
Official Full Name: superoxide dismutase 1provided by RGD
Primary source: RGD:3731
See related: AllianceGenome:RGD:3731
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CuZnSOD
Summary: Enables copper ion binding activity; protein phosphatase 2B binding activity; and superoxide dismutase activity. Involved in several processes, including cellular response to metal ion; hydrogen peroxide biosynthetic process; and removal of superoxide radicals. Located in several cellular components, including dense core granule; mitochondrial intermembrane space; and neuronal cell body. Part of protein-containing complex. Used to study hyperthyroidism; hypothyroidism; middle cerebral artery infarction; and sciatic neuropathy. Biomarker of several diseases, including artery disease (multiple); congenital diaphragmatic hernia; middle cerebral artery infarction; non-alcoholic steatohepatitis; and ocular hypertension. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and neurodegenerative disease (multiple). Orthologous to human SOD1 (superoxide dismutase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 6403.9), Kidney (RPKM 4173.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (42942742..42948399)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (29456673..29462249)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (30363282..30368858)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulatory mechanism of downregulation of SOD1 expression on cardiomyocyte function.
Title: Regulatory mechanism of downregulation of SOD1 expression on cardiomyocyte function.
Mechanism underlying the targeted regulation of the SOD1 3'UTR by the AUF1/Dicer1/miR-155/SOD1 pathway in sodium arsenite-induced liver injury.
Title: Mechanism underlying the targeted regulation of the SOD1 3'UTR by the AUF1/Dicer1/miR-155/SOD1 pathway in sodium arsenite-induced liver injury.
Na(+)/Ca(2+) exchanger isoform 1 takes part to the Ca(2+)-related prosurvival pathway of SOD1 in primary motor neurons exposed to beta-methylamino-L-alanine.
Title: Na(+)/Ca(2+) exchanger isoform 1 takes part to the Ca(2+)-related prosurvival pathway of SOD1 in primary motor neurons exposed to beta-methylamino-L-alanine.
Ellagic Acid Modulates the Amyloid Precursor Protein Gene via Superoxide Dismutase Regulation in the Entorhinal Cortex in an Experimental Alzheimer's Model.
Title: Ellagic Acid Modulates the Amyloid Precursor Protein Gene via Superoxide Dismutase Regulation in the Entorhinal Cortex in an Experimental Alzheimer's Model.
Intravenous infusion of mesenchymal stem cells delays disease progression in the SOD1G93A transgenic amyotrophic lateral sclerosis rat model.
Title: Intravenous infusion of mesenchymal stem cells delays disease progression in the SOD1G93A transgenic amyotrophic lateral sclerosis rat model.
In rat primary microglia the overexpression of the most-common SOD1 mutations linked to familial amyotrophic lateral sclerosis (G93A and A4V) leads to SOD1 intracellular accumulation, which correlates to autophagy dysfunction and microglial activation.
Title: Microglial overexpression of fALS-linked mutant SOD1 induces SOD1 processing impairment, activation and neurotoxicity and is counteracted by the autophagy inducer trehalose.
The mutant overexpressed SOD1(G93A) protein does not properly bind zinc in spinal cord tissue.
Title: Impaired Cu-Zn Superoxide Dismutase (SOD1) and Calcineurin (Cn) Interaction in ALS: A Presumed Consequence for TDP-43 and Zinc Aggregation in Tg SOD1(G93A) Rodent Spinal Cord Tissue.
These results indicate that stress conditions most probably altered the cell redox equilibrium, thus influencing the antioxidant response in brain cortex.
Title: Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress.
Results provide evidence that ALS mutant SOD1 inhibits axonal transport of mitochondria by inducing PINK1/Parkin-dependent Miro1 degradation.
Title: Amyotrophic lateral sclerosis-associated mutant SOD1 inhibits anterograde axonal transport of mitochondria by reducing Miro1 levels.
SOD1 protein expression is upregulated and associated with greater oxidant production in skeletal muscle from Ts65Dn mice.
Title: Oxidant production and SOD1 protein expression in single skeletal myofibers from Down syndrome mice.

Submit: New GeneRIF Correction See all GeneRIFs (91)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sod1 (e-PCR), detects polymorphism
- UniSTS:259146

Sod1 (e-PCR), detects polymorphism
- UniSTS:144477

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables copper ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables copper ion binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables copper ion binding	ISO Inferred from Sequence Orthology more info
enables copper ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables copper ion binding	TAS Traceable Author Statement more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 2B binding	IDA Inferred from Direct Assay more info	PubMed
enables protein phosphatase 2B binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase 2B binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 2B binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein-folding chaperone binding	IEA Inferred from Electronic Annotation more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables protein-folding chaperone binding	ISS Inferred from Sequence or Structural Similarity more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables superoxide dismutase activity	IBA Inferred from Biological aspect of Ancestor more info
enables superoxide dismutase activity	IDA Inferred from Direct Assay more info	PubMed
enables superoxide dismutase activity	IEA Inferred from Electronic Annotation more info
enables superoxide dismutase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables superoxide dismutase activity	ISO Inferred from Sequence Orthology more info
enables superoxide dismutase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within action potential initiation	ISO Inferred from Sequence Orthology more info
involved_in anterograde axonal transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within auditory receptor cell stereocilium organization	ISO Inferred from Sequence Orthology more info
involved_in auditory receptor cell stereocilium organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to ATP	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to potassium ion	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within determination of adult lifespan	ISO Inferred from Sequence Orthology more info
acts_upstream_of ectopic germ cell programmed cell death	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryo implantation	ISO Inferred from Sequence Orthology more info
involved_in embryo implantation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glutathione metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glutathione metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart contraction	ISO Inferred from Sequence Orthology more info
involved_in heart contraction	ISO Inferred from Sequence Orthology more info
involved_in heart contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in hydrogen peroxide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in hydrogen peroxide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in hydrogen peroxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hydrogen peroxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in hydrogen peroxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in hydrogen peroxide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within intracellular iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular iron ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in locomotory behavior	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within muscle cell cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in muscle cell cellular homeostasis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within myeloid cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in myeloid cell homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cholesterol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cholesterol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of developmental process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of reproductive process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neurofilament cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in neurofilament cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neuronal action potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ovarian follicle development	ISO Inferred from Sequence Orthology more info
involved_in ovarian follicle development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within peripheral nervous system myelin maintenance	ISO Inferred from Sequence Orthology more info
involved_in peripheral nervous system myelin maintenance	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of superoxide anion generation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of superoxide anion generation	ISO Inferred from Sequence Orthology more info
involved_in reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in reactive oxygen species metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitochondrial membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial membrane potential	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of multicellular organism growth	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within relaxation of vascular associated smooth muscle	ISO Inferred from Sequence Orthology more info
involved_in relaxation of vascular associated smooth muscle	ISS Inferred from Sequence or Structural Similarity more info
involved_in removal of superoxide radicals	IBA Inferred from Biological aspect of Ancestor more info
involved_in removal of superoxide radicals	IDA Inferred from Direct Assay more info	PubMed
involved_in removal of superoxide radicals	IEA Inferred from Electronic Annotation more info
involved_in removal of superoxide radicals	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within removal of superoxide radicals	ISO Inferred from Sequence Orthology more info
involved_in removal of superoxide radicals	ISS Inferred from Sequence or Structural Similarity more info
involved_in removal of superoxide radicals	TAS Traceable Author Statement more info	PubMed
involved_in response to amphetamine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to antipsychotic drug	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to axon injury	ISO Inferred from Sequence Orthology more info
involved_in response to axon injury	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to carbon monoxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to copper ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to copper ion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to heat	ISO Inferred from Sequence Orthology more info
involved_in response to heat	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in response to hydrogen peroxide	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to nutrient levels	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic substance	IEA Inferred from Electronic Annotation more info
involved_in response to organic substance	ISO Inferred from Sequence Orthology more info
involved_in response to organic substance	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to superoxide	ISO Inferred from Sequence Orthology more info
involved_in response to superoxide	ISO Inferred from Sequence Orthology more info
involved_in response to superoxide	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina homeostasis	ISO Inferred from Sequence Orthology more info
involved_in retina homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in retrograde axonal transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within superoxide anion generation	ISO Inferred from Sequence Orthology more info
involved_in superoxide metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within superoxide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in superoxide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in superoxide metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in superoxide metabolic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within transmission of nerve impulse	ISO Inferred from Sequence Orthology more info
involved_in transmission of nerve impulse	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendrite cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in dense core granule	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: superoxide dismutase [Cu-Zn]

Names: superoxide dismutase 1, soluble

NP_058746.1

EC 1.15.1.1

XP_063126359.1

EC 1.15.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017050.1 → NP_058746.1 superoxide dismutase [Cu-Zn]

See identical proteins and their annotated locations for NP_058746.1

Status: PROVISIONAL

Source sequence(s)

Y00404

UniProtKB/Swiss-Prot

P07632

UniProtKB/TrEMBL

A6JLB7, Q6LDS4

Conserved Domains (1) summary

cd00305
Location:3 → 147

Cu-Zn_Superoxide_Dismutase; Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the ...