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Rbp2 retinol binding protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24710, updated on 5-Mar-2024

Summary

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Official Symbol
Rbp2provided by RGD
Official Full Name
retinol binding protein 2provided by RGD
Primary source
RGD:3544
See related
Ensembl:ENSRNOG00000013932 AllianceGenome:RGD:3544
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables retinol binding activity. Predicted to be involved in fatty acid transport. Located in cytosol. Orthologous to human RBP2 (retinol binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 16.0), Liver (RPKM 7.5) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
8q31
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (107958670..107983850)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (99079293..99104489)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (106479253..106527726)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene nicotinamide nucleotide adenylyltransferase 3 Neighboring gene retinol binding protein 1 Neighboring gene NME/NM23 nucleoside diphosphate kinase 2, pseudogene 8 Neighboring gene COPI coat complex subunit beta 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Pregnancy and maternal iron deficiency stimulate hepatic CRBPII expression in rats. Cottin SC, et al. J Nutr Biochem, 2016 Jun. PMID 27142737
  2. The structure and dynamics of rat apo-cellular retinol-binding protein II in solution: comparison with the X-ray structure. Lu J, et al. J Mol Biol, 1999 Mar 5. PMID 10047490
  3. Genetic isolation of a region of chromosome 8 that exerts major effects on blood pressure and cardiac mass in the spontaneously hypertensive rat. Kren V, et al. J Clin Invest, 1997 Feb 15. PMID 9045857, Free PMC Article
  4. Crystal structures of holo and apo-cellular retinol-binding protein II. Winter NS, et al. J Mol Biol, 1993 Apr 20. PMID 8487303
  5. Rat cellular retinol-binding protein II: use of a cloned cDNA to define its primary structure, tissue-specific expression, and developmental regulation. Li E, et al. Proc Natl Acad Sci U S A, 1986 Aug. PMID 3461459, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that, as compared to controls, CrbpII expression in liver is up-regulated by pregnancy and further increased by iron deficiency; maternal iron deficiency has little impact on vitamin A levels and gene expression in placenta, but increases retinol storage in fetal liver; regulation of CrbpII expression in liver may play important roles in vitamin A metabolism in pregnant females and in fetal development.
    Title: Pregnancy and maternal iron deficiency stimulate hepatic CRBPII expression in rats.
  2. These results suggest that the elevated mRNA expression levels of Rbp2 and Apoa4 in the rats with SB contribute to the effective esterification and transport of vitamin A.
    Title: Massive bowel resection upregulates the intestinal mRNA expression levels of cellular retinol-binding protein II and apolipoprotein A-IV and alters the intestinal vitamin A status in rats.
  3. protein-ligand interaction differences between CRBP-I and CRBP-II
    Title: New insights on the protein-ligand interaction differences between the two primary cellular retinol carriers.
  4. results suggest that CRBPII gene expression during the perinatal period is associated with abrupt acetylation of histones H3 and H4 followed by the binding of CBP/p300 and RXRalpha.
    Title: Induction of histone acetylation on the CRBPII gene in perinatal rat small intestine.
  5. analysis of conformational flexibility of rat cellular retinol-binding protein I (CRBP I) and cellular retinol-binding protein II (CRBP II)
    Title: Two homologous rat cellular retinol-binding proteins differ in local conformational flexibility.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding ISO
Inferred from Sequence Orthology
more info
  
enables retinal binding IEA
Inferred from Electronic Annotation
more info
  
enables retinol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables retinol binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retinol metabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
retinol-binding protein 2
Names
CRBP-II
Retinol-binding protein 2, cellular
cellular retinol-binding protein II
retinol binding protein 2, cellular

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012640.2 → NP_036772.2  retinol-binding protein 2

    See identical proteins and their annotated locations for NP_036772.2

    Status: VALIDATED

    Source sequence(s)
    CN542437, M13949
    UniProtKB/Swiss-Prot
    P06768
    UniProtKB/TrEMBL
    A6I2B3
    Conserved Domains (1) summary
    cd19463
    Location:4 → 134
    CRBP2; cellular retinol-binding protein 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    107958670..107983850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243607.3 → XP_006243669.1  retinol-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006243669.1

    UniProtKB/Swiss-Prot
    P06768
    UniProtKB/TrEMBL
    A6I2B3
    Related
    ENSRNOP00000018755.5
    Conserved Domains (1) summary
    cd19463
    Location:4 → 134
    CRBP2; cellular retinol-binding protein 2

  2. XM_039080832.2 → XP_038936760.1  retinol-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    P06768
    UniProtKB/TrEMBL
    A6I2B3
    Conserved Domains (1) summary
    cd19463
    Location:4 → 134
    CRBP2; cellular retinol-binding protein 2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06768.3 GenPept UniProtKB/Swiss-Prot:P06768

Gene LinkOut

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