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Ptprc protein tyrosine phosphatase, receptor type, C [ Rattus norvegicus (Norway rat) ]

Gene ID: 24699, updated on 4-Jan-2025

Summary

Official Symbol
Ptprcprovided by RGD
Official Full Name
protein tyrosine phosphatase, receptor type, Cprovided by RGD
Primary source
RGD:3451
See related
EnsemblRapid:ENSRNOG00000000655 AllianceGenome:RGD:3451
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lca; RT7; CD45; L-CA; T200
Summary
Enables protein tyrosine phosphatase activity. Involved in several processes, including T cell receptor signaling pathway; response to aldosterone; and response to gamma radiation. Located in cell surface and plasma membrane. Biomarker of hypertension and retinal degeneration. Human ortholog(s) of this gene implicated in multiple sclerosis; primary immunodeficiency disease; and severe combined immunodeficiency. Orthologous to human PTPRC (protein tyrosine phosphatase receptor type C). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 1284.0), Thymus (RPKM 1219.5) and 4 other tissues See more
Orthologs
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Genomic context

See Ptprc in Genome Data Viewer
Location:
13q13
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (52147717..52259810, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (49596193..49708283, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (55061561..55174150, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352541 Neighboring gene microRNA 181a-1 Neighboring gene microRNA 181b-1 Neighboring gene microRNA 3570 Neighboring gene terminal nucleotidyltransferase 2, pseudogene 1 Neighboring gene uncharacterized LOC102548579

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ankyrin binding  
enables heparan sulfate proteoglycan binding  
enables heparin binding  
enables histone H2AXY142 phosphatase activity  
enables non-membrane spanning protein tyrosine phosphatase activity  
enables protein binding PubMed 
enables protein kinase binding  
enables protein kinase binding  
enables protein kinase regulator activity PubMed 
enables protein tyrosine kinase inhibitor activity  
enables protein tyrosine phosphatase activity  
enables protein tyrosine phosphatase activity  
enables protein tyrosine phosphatase activity PubMed 
enables protein tyrosine phosphatase activity  
enables protein tyrosine phosphatase activity  
enables protein tyrosine phosphatase activity, metal-dependent  
enables signaling receptor binding  
enables spectrin binding  
enables transmembrane receptor protein tyrosine phosphatase activity  
enables transmembrane receptor protein tyrosine phosphatase activity PubMed 
Items 1 - 25 of 94
Process Evidence Code Pubs
acts_upstream_of_or_within B cell differentiation  
involved_in B cell differentiation  
acts_upstream_of B cell proliferation  
involved_in B cell proliferation  
involved_in B cell proliferation  
acts_upstream_of_or_within B cell receptor signaling pathway  
involved_in B cell receptor signaling pathway  
involved_in B cell receptor signaling pathway  
acts_upstream_of MAPK cascade  
involved_in T cell differentiation  
involved_in T cell differentiation  
acts_upstream_of_or_within T cell proliferation  
involved_in T cell receptor signaling pathway  
involved_in T cell receptor signaling pathway PubMed 
involved_in T cell receptor signaling pathway  
involved_in T cell receptor signaling pathway  
acts_upstream_of alpha-beta T cell proliferation  
involved_in bone marrow development  
involved_in cell cycle phase transition  
involved_in chromatin remodeling  
acts_upstream_of_or_within defense response to virus  
involved_in defense response to virus  
involved_in defense response to virus  
involved_in dephosphorylation  
involved_in dephosphorylation  
acts_upstream_of extrinsic apoptotic signaling pathway  
acts_upstream_of gamma-delta T cell differentiation  
involved_in hematopoietic progenitor cell differentiation  
acts_upstream_of_or_within heterotypic cell-cell adhesion  
acts_upstream_of_or_within leukocyte cell-cell adhesion  
involved_in natural killer cell differentiation  
involved_in negative regulation of ERK1 and ERK2 cascade  
involved_in negative regulation of T cell mediated cytotoxicity  
involved_in negative regulation of T cell mediated cytotoxicity  
involved_in negative regulation of cell adhesion involved in substrate-bound cell migration  
involved_in negative regulation of cytokine-mediated signaling pathway  
involved_in negative regulation of cytokine-mediated signaling pathway  
involved_in negative regulation of interleukin-2 production  
involved_in negative regulation of interleukin-4-mediated signaling pathway  
acts_upstream_of_or_within negative regulation of peptidyl-tyrosine phosphorylation  
acts_upstream_of_or_within negative regulation of protein autophosphorylation  
involved_in negative regulation of protein kinase activity  
involved_in negative regulation of protein kinase activity  
involved_in negative regulation of receptor signaling pathway via JAK-STAT  
involved_in negative regulation of transcription by RNA polymerase II  
acts_upstream_of_or_within negative thymic T cell selection  
acts_upstream_of peptidyl-tyrosine phosphorylation  
acts_upstream_of_or_within positive regulation of B cell proliferation  
involved_in positive regulation of B cell proliferation  
involved_in positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway  
acts_upstream_of_or_within positive regulation of MAP kinase activity  
acts_upstream_of_or_within positive regulation of MAPK cascade  
involved_in positive regulation of MAPK cascade  
acts_upstream_of_or_within positive regulation of T cell differentiation  
acts_upstream_of_or_within positive regulation of T cell mediated cytotoxicity  
acts_upstream_of_or_within positive regulation of T cell mediated immunity  
involved_in positive regulation of T cell proliferation  
involved_in positive regulation of T cell proliferation  
acts_upstream_of_or_within positive regulation of alpha-beta T cell proliferation  
involved_in positive regulation of antigen receptor-mediated signaling pathway  
involved_in positive regulation of antigen receptor-mediated signaling pathway  
involved_in positive regulation of calcium-mediated signaling  
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway  
acts_upstream_of_or_within positive regulation of gamma-delta T cell differentiation  
involved_in positive regulation of hematopoietic stem cell migration  
acts_upstream_of_or_within positive regulation of humoral immune response mediated by circulating immunoglobulin  
involved_in positive regulation of immunoglobulin production  
involved_in positive regulation of interleukin-2 production  
acts_upstream_of_or_within positive regulation of isotype switching to IgG isotypes  
involved_in positive regulation of peptidyl-tyrosine phosphorylation  
involved_in positive regulation of phagocytosis  
involved_in positive regulation of stem cell proliferation  
involved_in positive regulation of tumor necrosis factor production  
acts_upstream_of_or_within positive thymic T cell selection  
acts_upstream_of protein autophosphorylation  
involved_in protein dephosphorylation  
involved_in protein dephosphorylation  
involved_in protein dephosphorylation PubMed 
involved_in regulation of T cell receptor signaling pathway  
involved_in regulation of cell cycle  
involved_in regulation of cell cycle  
acts_upstream_of_or_within regulation of extrinsic apoptotic signaling pathway  
involved_in regulation of gene expression PubMed 
involved_in regulation of gene expression  
acts_upstream_of_or_within regulation of humoral immune response mediated by circulating immunoglobulin  
involved_in regulation of interleukin-8 production  
involved_in regulation of phagocytosis  
involved_in release of sequestered calcium ion into cytosol  
involved_in release of sequestered calcium ion into cytosol  
involved_in response to aldosterone PubMed 
involved_in response to gamma radiation PubMed 
involved_in signal transduction  
involved_in stem cell development  
Items 1 - 25 of 94
Component Evidence Code Pubs
located_in bleb  
located_in cell periphery  
located_in cell surface PubMed 
located_in cell surface  
located_in cytoplasmic side of plasma membrane PubMed 
located_in external side of plasma membrane  
located_in focal adhesion  
located_in focal adhesion  
located_in membrane  
located_in membrane microdomain  
located_in membrane raft  
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in synapse  

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase C
Names
T200 glycoprotein
leucocyte common antigen
leukocyte common antigen A
leukocyte common antigen B
protein tyrosine phosphatase, receptor-type, c polypeptide
NP_001103357.1
NP_001103358.1
NP_001103359.1
NP_001103360.1
NP_612516.2
XP_006249974.1
XP_008767756.1
XP_038946275.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109887.2NP_001103357.1  receptor-type tyrosine-protein phosphatase C isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two in-frame exons compared to variant 4. The resulting isoform (3) is shorter compared to isoform 4.
    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A6ICK1
    Conserved Domains (5) summary
    smart00194
    Location:538797
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:566797
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:283348
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12453
    Location:527
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:120174
    CD45; Leukocyte receptor CD45
  2. NM_001109888.2NP_001103358.1  receptor-type tyrosine-protein phosphatase C isoform 5 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two in-frame exons compared to variant 4. The resulting isoform (5) is shorter compared to isoform 4.
    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A8L2PZM8
    Related
    ENSRNOP00000110329.1, ENSRNOT00000149921.1
    Conserved Domains (5) summary
    smart00194
    Location:531790
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:559790
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:276341
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12453
    Location:527
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:113167
    CD45; Leukocyte receptor CD45
  3. NM_001109889.2NP_001103359.1  receptor-type tyrosine-protein phosphatase C isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons compared to variant 4. The resulting isoform (2) is shorter compared to isoform 4.
    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A8L2PZM8
    Related
    ENSRNOP00000057042.2, ENSRNOT00000060292.6
    Conserved Domains (5) summary
    smart00194
    Location:530789
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:558789
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:275340
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12453
    Location:527
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:112166
    CD45; Leukocyte receptor CD45
  4. NM_001109890.2NP_001103360.1  receptor-type tyrosine-protein phosphatase C isoform 1 precursor

    See identical proteins and their annotated locations for NP_001103360.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks three in-frame exons compared to variant 4. The resulting isoform (1) is shorter compared to isoform 4.
    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A6ICK0, A6ICK1
    Related
    ENSRNOP00000000814.6, ENSRNOT00000000814.6
    Conserved Domains (5) summary
    smart00194
    Location:489748
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:517748
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:234299
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12453
    Location:527
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:71125
    CD45; Leukocyte receptor CD45
  5. NM_001429494.1NP_001416423.1  receptor-type tyrosine-protein phosphatase C isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A8L2QGD4, A6ICK2
  6. NM_138507.3NP_612516.2  receptor-type tyrosine-protein phosphatase C isoform 4 precursor

    See identical proteins and their annotated locations for NP_612516.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    P04157
    UniProtKB/TrEMBL
    A0A8L2QFX7
    Related
    ENSRNOP00000063859.1, ENSRNOT00000064785.5
    Conserved Domains (5) summary
    smart00194
    Location:621880
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:649880
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:366431
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12453
    Location:527
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:203257
    CD45; Leukocyte receptor CD45

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    52147717..52259810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090347.1XP_038946275.1  receptor-type tyrosine-protein phosphatase C isoform X3

    UniProtKB/TrEMBL
    A6ICK1
    Conserved Domains (5) summary
    cd00063
    Location:210275
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14557
    Location:520720
    R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1
    cd14558
    Location:8301035
    R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2
    pfam12567
    Location:47103
    CD45; Leukocyte receptor CD45
    NF033860
    Location:365424
    Wzy_O6_O28; oligosaccharide repeat unit polymerase
  2. XM_006249912.4XP_006249974.1  receptor-type tyrosine-protein phosphatase C isoform X2

    Related
    ENSRNOP00000030503.5, ENSRNOT00000029878.8
    Conserved Domains (6) summary
    PHA03255
    Location:22149
    PHA03255; BDLF3; Provisional
    smart00194
    Location:579838
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:607838
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:324389
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12453
    Location:527
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:161215
    CD45; Leukocyte receptor CD45
  3. XM_008769534.3XP_008767756.1  receptor-type tyrosine-protein phosphatase C isoform X1

    UniProtKB/TrEMBL
    A6ICK1
    Related
    ENSRNOP00000100800.1, ENSRNOT00000160765.1
    Conserved Domains (6) summary
    PHA03255
    Location:11152
    PHA03255; BDLF3; Provisional
    smart00194
    Location:580839
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:608839
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:325390
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12453
    Location:527
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:162216
    CD45; Leukocyte receptor CD45
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