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Prps2 phosphoribosyl pyrophosphate synthetase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24689, updated on 11-Apr-2024

Summary

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Symbol
Prps2provided by RGD
Full Name
phosphoribosyl pyrophosphate synthetase 2provided by RGD
Primary source
RGD:3415
See related
Ensembl:ENSRNOG00000004160 AllianceGenome:RGD:3415
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables several functions, including magnesium ion binding activity; purine ribonucleotide binding activity; and ribose phosphate diphosphokinase activity. Involved in 5-phosphoribose 1-diphosphate biosynthetic process; AMP biosynthetic process; and animal organ regeneration. Part of ribose phosphate diphosphokinase complex. Orthologous to human PRPS2 (phosphoribosyl pyrophosphate synthetase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 165.1), Thymus (RPKM 152.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
Xq13
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (30592845..30630127)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (26975915..27013184)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (28435275..28472882)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein LOC686042 Neighboring gene U6 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA70 Neighboring gene toll-like receptor 7 Neighboring gene Y box binding protein 1, pseudogene 7 Neighboring gene toll-like receptor 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Complete cDNA sequence of rat phosphoribosylpyrophosphate synthetase subunit II (PRS II). Ishijima S, et al. Nucleic Acids Res, 1989 Nov 11. PMID 2555778, Free PMC Article
  2. Rat liver phosphoribosylpyrophosphate synthetase is activated by free Mg2+ in a manner that overcomes its inhibition by nucleotides. Sonoda T, et al. Biochim Biophys Acta, 1998 Sep 8. PMID 9748490
  3. Kinetic and regulatory properties of rat liver phosphoribosylpyrophosphate synthetase complex are partly distinct from those of isolated recombinant component catalytic subunits. Sonoda T, et al. J Biochem, 1997 Sep. PMID 9348095
  4. Nucleotide and deduced amino acid sequences of two distinct cDNAs for rat phosphoribosylpyrophosphate synthetase. Taira M, et al. J Biol Chem, 1987 Nov 5. PMID 2822704
  5. Expression of rat phosphoribosylpyrophosphate synthetase subunits I and II in Escherichia coli. Isolation and characterization of the recombinant isoforms. Ishijima S, et al. J Biol Chem, 1991 Aug 25. PMID 1651917

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ADP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables AMP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GDP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbohydrate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ribose phosphate diphosphokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribose phosphate diphosphokinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribose phosphate diphosphokinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribose phosphate diphosphokinase activity ISO
Inferred from Sequence Orthology
more info
  
enables ribose phosphate diphosphokinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in 5-phosphoribose 1-diphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 5-phosphoribose 1-diphosphate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 5-phosphoribose 1-diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 5-phosphoribose 1-diphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in AMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in animal organ regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in pentose-phosphate shunt IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose-phosphate shunt ISO
Inferred from Sequence Orthology
more info
  
involved_in purine nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribonucleoside monophosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribose phosphate diphosphokinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribose phosphate diphosphokinase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ribose-phosphate pyrophosphokinase 2
Names
PRS-II
Phophoribosylpyrophosphate synthetase, subunit II
phosphoribosyl pyrophosphate synthase II
phosphoribosyl pyrophosphate synthetase II
ribose-phosphate pyrophosphokinase 2-like
NP_036766.1
XP_006256891.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012634.2 → NP_036766.1  ribose-phosphate pyrophosphokinase 2

    See identical proteins and their annotated locations for NP_036766.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/Swiss-Prot
    P09330, Q63462
    UniProtKB/TrEMBL
    A0A8L2R3X1, A6K2F9
    Conserved Domains (1) summary
    COG0462
    Location:1 → 313
    PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    30592845..30630127
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256829.5 → XP_006256891.1  ribose-phosphate pyrophosphokinase 2 isoform X1

    See identical proteins and their annotated locations for XP_006256891.1

    UniProtKB/TrEMBL
    A0A8L2Q1L2, A0A8L2R3X1
    Related
    ENSRNOP00000005615.2
    Conserved Domains (1) summary
    COG0462
    Location:1 → 316
    PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09330.3 GenPept UniProtKB/Swiss-Prot:P09330

Gene LinkOut

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