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Tradd TNFRSF1A-associated via death domain [ Rattus norvegicus (Norway rat) ]

Gene ID: 246756, updated on 13-Apr-2024

Summary

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Official Symbol
Traddprovided by RGD
Official Full Name
TNFRSF1A-associated via death domainprovided by RGD
Primary source
RGD:621313
See related
Ensembl:ENSRNOG00000015179 AllianceGenome:RGD:621313
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables tumor necrosis factor receptor binding activity. Predicted to be involved in several processes, including cellular response to tumor necrosis factor; positive regulation of NF-kappaB transcription factor activity; and positive regulation of intracellular signal transduction. Located in membrane raft. Part of protein-containing complex. Orthologous to human TRADD (TNFRSF1A associated via death domain). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 62.9), Adrenal (RPKM 62.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
19q11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50046057..50048158, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33136148..33142714, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37214461..37221099, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene core-binding factor subunit beta Neighboring gene ribosomal protein L27, pseudogene 10 Neighboring gene phagosome assembly factor 1 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 Neighboring gene F-box and leucine-rich repeat protein 8 Neighboring gene heat shock transcription factor 4 Neighboring gene microtubule associated tyrosine carboxypeptidase 1 Neighboring gene nucleolar protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Vulnerability of monoaminergic neurons in the brainstem of the zitter rat in oxidative stress. Ueda S, et al. Prog Brain Res, 2002. PMID 12143389
  2. Time course profiling of the retinal transcriptome after optic nerve transection and optic nerve crush. Agudo M, et al. Mol Vis, 2008 Jun 3. PMID 18552980, Free PMC Article
  3. Effect of infliximab combined with methylprednisolone on expressions of NF-κB, TRADD, and FADD in rat acute spinal cord injury. Chengke L, et al. Spine (Phila Pa 1976), 2013 Jun 15. PMID 23574812
  4. MicroRNA-30c-2-3p negatively regulates NF-κB signaling and cell cycle progression through downregulation of TRADD and CCNE1 in breast cancer. Shukla K, et al. Mol Oncol, 2015 Jun. PMID 25732226, Free PMC Article
  5. Role of heme oxygenase 1 in TNF/TNF receptor-mediated apoptosis after hepatic ischemia/reperfusion in rats. Kim SJ, et al. Shock, 2013 Apr. PMID 23423194

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show that both infliximab and methylprednisolone (MP) could lower the expressions of NF-kappaB, TRADD, and FADD 24 hours after the acute spinal cord injury (ASCI).
    Title: Effect of infliximab combined with methylprednisolone on expressions of NF-κB, TRADD, and FADD in rat acute spinal cord injury.
  2. These data suggest that the decrease in TRADD resulting from enhanced ubiquitin-dependent degradation is involved in obstructive renal injury
    Title: Decrease in tumor necrosis factor-alpha receptor-associated death domain results from ubiquitin-dependent degradation in obstructive renal injury in rats.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables death domain binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane receptor protein tyrosine kinase adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane receptor protein tyrosine kinase adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables tumor necrosis factor receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
  
involved_in extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of hair follicle development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  
part_of tumor necrosis factor receptor superfamily complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of tumor necrosis factor receptor superfamily complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tumor necrosis factor receptor type 1-associated DEATH domain protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100480.1 → NP_001093950.1  tumor necrosis factor receptor type 1-associated DEATH domain protein

    See identical proteins and their annotated locations for NP_001093950.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A6IYM5, D3ZZC5
    Conserved Domains (2) summary
    pfam09034
    Location:51 → 148
    TRADD_N; TRADD, N-terminal domain
    cl14633
    Location:214 → 301
    DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    50046057..50048158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097477.2 → XP_038953405.1  tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1

    Conserved Domains (1) summary
    pfam09034
    Location:51 → 148
    TRADD_N; TRADD, N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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