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Oas2 2'-5' oligoadenylate synthetase 2 [ Mus musculus (house mouse) ]

Gene ID: 246728, updated on 21-Apr-2024

Summary

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Official Symbol
Oas2provided by MGI
Official Full Name
2'-5' oligoadenylate synthetase 2provided by MGI
Primary source
MGI:MGI:2180852
See related
Ensembl:ENSMUSG00000032690 AllianceGenome:MGI:2180852
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Oasl11
Summary
Enables 2'-5'-oligoadenylate synthetase activity and double-stranded RNA binding activity. Involved in defense response to virus; regulation of lactation; and type I interferon signaling pathway. Acts upstream of or within RNA catabolic process; interleukin-27-mediated signaling pathway; and response to bacterium. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytosol; membrane; and nucleoplasm. Is expressed in embryo. Orthologous to human OAS2 (2'-5'-oligoadenylate synthetase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 7.4), mammary gland adult (RPKM 7.0) and 20 other tissues See more
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Genomic context

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Location:
5 F; 5 60.64 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (120868398..120887949, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (120730333..120749886, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4782 Neighboring gene RAS protein activator like 1 (GAP1 like) Neighboring gene STARR-positive B cell enhancer ABC_E11300 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:121135771-121135981 Neighboring gene deltex 1, E3 ubiquitin ligase Neighboring gene STARR-positive B cell enhancer ABC_E8075 Neighboring gene STARR-positive B cell enhancer ABC_E6371 Neighboring gene STARR-seq mESC enhancer starr_14247 Neighboring gene STARR-seq mESC enhancer starr_14249 Neighboring gene 2'-5' oligoadenylate synthetase 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:121225553-121225736 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:121225792-121225979 Neighboring gene 2'-5' oligoadenylate synthetase 1E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A mutation in the viral sensor 2'-5'-oligoadenylate synthetase 2 causes failure of lactation. Oakes SR, et al. PLoS Genet, 2017 Nov. PMID 29117179, Free PMC Article
  2. Natural mutations in a 2'-5' oligoadenylate synthetase transgene revealed residues essential for enzyme activity. Sarkar SN, et al. Biochemistry, 2005 May 10. PMID 15865429
  3. IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection. Kwock JT, et al. Sci Adv, 2020 Apr. PMID 32270034, Free PMC Article
  4. Structural and functional genomics and evolutionary relationships in the cluster of genes encoding murine 2',5'-oligoadenylate synthetases. Mashimo T, et al. Genomics, 2003 Nov. PMID 14559211
  5. Gene structure of the murine 2'-5'-oligoadenylate synthetase family. Eskildsen S, et al. Cell Mol Life Sci, 2002 Jul. PMID 12222967

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2'-5'-oligoadenylate synthetase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2'-5'-oligoadenylate synthetase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2'-5'-oligoadenylate synthetase activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-27-mediated signaling pathway IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in interleukin-27-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of viral genome replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of lactation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to virus TAS
Traceable Author Statement
more info
 PubMed 
involved_in type I interferon-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
2'-5'-oligoadenylate synthase 2
Names
(2-5')oligo(A) synthase 2
2',5'-oligoadenylate synthetase-like 11
2,5-oligoadenylate synthetase-like 11
2-5A synthase 2
NP_001334377.1
NP_660262.2
XP_036021033.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347448.1 → NP_001334377.1  2'-5'-oligoadenylate synthase 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC115937
    Consensus CDS
    CCDS84949.1
    UniProtKB/Swiss-Prot
    E9Q9A9
    Related
    ENSMUSP00000080209.7, ENSMUST00000081491.13

  2. NM_145227.3 → NP_660262.2  2'-5'-oligoadenylate synthase 2 isoform 2

    See identical proteins and their annotated locations for NP_660262.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB067535, BC118538, BU694306
    Consensus CDS
    CCDS19625.2
    UniProtKB/Swiss-Prot
    E9Q9A9, Q8K4E5, Q8VI92
    Related
    ENSMUSP00000060082.7, ENSMUST00000053909.13
    Conserved Domains (2) summary
    cd05400
    Location:401 → 583
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam10421
    Location:538 → 721
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    120868398..120887949 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165140.1 → XP_036021033.1  2'-5'-oligoadenylate synthase 2 isoform X1

RNA

  1. XR_387564.4 RNA Sequence

  2. XR_004942516.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q9A9.1 GenPept UniProtKB/Swiss-Prot:E9Q9A9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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