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Pklr pyruvate kinase L/R [ Rattus norvegicus (Norway rat) ]

Gene ID: 24651, updated on 4-Jan-2025

Summary

Official Symbol
Pklrprovided by RGD
Official Full Name
pyruvate kinase L/Rprovided by RGD
Primary source
RGD:3336
See related
EnsemblRapid:ENSRNOG00000020420 AllianceGenome:RGD:3336
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PK1; PKL; Pklg
Summary
Enables monosaccharide binding activity and pyruvate kinase activity. Involved in several processes, including cellular response to epinephrine stimulus; cellular response to insulin stimulus; and pyruvate metabolic process. Predicted to be located in plasma membrane. Predicted to be part of pyruvate kinase complex. Predicted to be active in cytosol. Biomarker of hyperglycemia and metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; malaria; pyruvate kinase deficiency of red cells; and type 2 diabetes mellitus. Orthologous to human PKLR (pyruvate kinase L/R). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 407.7), Kidney (RPKM 72.2) and 1 other tissue See more
Orthologs
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Genomic context

See Pklr in Genome Data Viewer
Location:
2q34
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (176840779..176849637)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (174543008..174551863)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (188449158..188458034)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene RUN and SH3 domain containing 1 Neighboring gene RNA, U6 small nuclear 909 Neighboring gene farnesyl diphosphate synthase Neighboring gene hyperpolarization-activated cyclic nucleotide-gated potassium channel 3 Neighboring gene CDC-like kinase 2 Neighboring gene microRNA 3541 Neighboring gene secretory carrier membrane protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding  
enables kinase activity  
enables magnesium ion binding  
enables monosaccharide binding PubMed 
enables potassium ion binding  
enables pyruvate kinase activity  
enables pyruvate kinase activity PubMed 
enables pyruvate kinase activity  
enables pyruvate kinase activity  
Process Evidence Code Pubs
involved_in cellular response to epinephrine stimulus PubMed 
involved_in cellular response to insulin stimulus  
involved_in cellular response to insulin stimulus PubMed 
involved_in glycolytic process  
involved_in glycolytic process PubMed 
involved_in glycolytic process  
involved_in glycolytic process  
involved_in pyruvate biosynthetic process PubMed 
involved_in response to ATP PubMed 
involved_in response to cAMP PubMed 
involved_in response to glucose PubMed 
involved_in response to hypoxia PubMed 
involved_in response to metal ion PubMed 
involved_in response to nutrient PubMed 
acts_upstream_of_or_within response to other organism  
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm  
is_active_in cytosol  
located_in plasma membrane  
part_of pyruvate kinase complex  

General protein information

Preferred Names
pyruvate kinase PKLR
Names
L-PK
pyruvate kinase isozymes L/R
pyruvate kinase isozymes R/L
pyruvate kinase, liver and RBC
pyruvate kinase, liver and red blood cell
NP_036756.3
XP_006232655.1
XP_038957668.1
XP_063137374.1
XP_063137375.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012624.3NP_036756.3  pyruvate kinase PKLR

    See identical proteins and their annotated locations for NP_036756.3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A0H2UI07, B1WBN9
    Related
    ENSRNOP00000093132.1, ENSRNOT00000103387.2
    Conserved Domains (2) summary
    cd00288
    Location:54542
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
    TIGR01064
    Location:55539
    pyruv_kin; pyruvate kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    176840779..176849637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232593.5XP_006232655.1  pyruvate kinase PKLR isoform X1

    See identical proteins and their annotated locations for XP_006232655.1

    UniProtKB/Swiss-Prot
    P04763, P12928, Q64618
    UniProtKB/TrEMBL
    A0A0H2UI07, A6J6C1
    Related
    ENSRNOP00000027700.3, ENSRNOT00000027700.8
    Conserved Domains (1) summary
    cd00288
    Location:85573
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
  2. XM_063281305.1XP_063137375.1  pyruvate kinase PKLR isoform X3

  3. XM_063281304.1XP_063137374.1  pyruvate kinase PKLR isoform X3

  4. XM_039101740.2XP_038957668.1  pyruvate kinase PKLR isoform X2

    UniProtKB/TrEMBL
    A0A0H2UI07
    Conserved Domains (1) summary
    cd00288
    Location:21509
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

RNA

  1. XR_005500240.2 RNA Sequence

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