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Pgm1 phosphoglucomutase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24645, updated on 16-Apr-2024

Summary

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Official Symbol
Pgm1provided by RGD
Official Full Name
phosphoglucomutase 1provided by RGD
Primary source
RGD:3316
See related
Ensembl:ENSRNOG00000009889 AllianceGenome:RGD:3316
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables phosphoglucomutase activity. Involved in cellular response to magnetism and glucose metabolic process. Located in Z disc. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation It; endometrial cancer; and teratoma. Orthologous to human PGM1 (phosphoglucomutase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 3276.7), Heart (RPKM 438.1) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q33
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (119710734..119770159)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (114595298..114654728)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (118743632..118803055)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479015 Neighboring gene ALG6, alpha-1,3-glucosyltransferase Neighboring gene integrin subunit beta 3 binding protein Neighboring gene EF-hand calcium binding domain 7 Neighboring gene receptor tyrosine kinase-like orphan receptor 1 Neighboring gene U6 spliceosomal RNA Neighboring gene RNA, U6 small nuclear 233

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Differentiation of chromaffin cells elicited by ELF MF modifies gene expression pattern. Olivares-Bañuelos T, et al. Cell Biol Int, 2004. PMID 15109983
  2. Long-term alcohol intake enhances ADP-ribosylation of the multifunctional enzyme, phosphoglucomutase, in rat liver. Nomura F, et al. Hepatology, 1996 Nov. PMID 8903405
  3. Isolation and expression of a rat liver cDNA encoding phosphoglucomutase. Rivera AA, et al. Gene, 1993 Nov 15. PMID 8224913
  4. Isolation and immunohistochemical localization of a chondroitin sulfate proteoglycan from adult rat brain. Normand G, et al. J Neurochem, 1988 Sep. PMID 3411319
  5. Induced Structural Disorder as a Molecular Mechanism for Enzyme Dysfunction in Phosphoglucomutase 1 Deficiency. Stiers KM, et al. J Mol Biol, 2016 Apr 24. PMID 26972339, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphoglucomutase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoglucomutase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoglucomutase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoglucomutase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to magnetism IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in glucose metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular calcium ion homeostasis TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphoglucomutase-1
Names
PGM 1
glucose phosphomutase 1
NP_058729.2
XP_006238504.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429272.1 → NP_001416201.1  phosphoglucomutase-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  2. NM_001429273.1 → NP_001416202.1  phosphoglucomutase-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  3. NM_017033.3 → NP_058729.2  phosphoglucomutase-1 isoform 2

    See identical proteins and their annotated locations for NP_058729.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P38652
    UniProtKB/TrEMBL
    A6JRM5, F7F2L9, Q499Q4
    Related
    ENSRNOP00000013785.4, ENSRNOT00000013785.7
    Conserved Domains (2) summary
    cd03085
    Location:5 → 562
    PGM1; Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction, ...
    PLN02307
    Location:1 → 562
    PLN02307; phosphoglucomutase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    119710734..119770159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238442.5 → XP_006238504.1  phosphoglucomutase-1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRI9, A0A8I6AV00
    Related
    ENSRNOP00000097832.1
    Conserved Domains (2) summary
    cd03085
    Location:24 → 580
    PGM1; Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction, ...
    PLN02307
    Location:27 → 580
    PLN02307; phosphoglucomutase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38652.2 GenPept UniProtKB/Swiss-Prot:P38652

Gene LinkOut

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