U.S. flag

An official website of the United States government

Pgk1 phosphoglycerate kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24644, updated on 4-Jan-2025

Summary

Official Symbol
Pgk1provided by RGD
Official Full Name
phosphoglycerate kinase 1provided by RGD
Primary source
RGD:619878
See related
EnsemblRapid:ENSRNOG00000058249 AllianceGenome:RGD:619878
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pgk
Summary
Enables ADP binding activity; ATP binding activity; and phosphoglycerate kinase activity. Involved in gluconeogenesis and glycolytic process. Predicted to be located in extracellular space; membrane raft; and mitochondrial matrix. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in hemolytic anemia and phosphoglycerate kinase 1 deficiency. Orthologous to human PGK1 (phosphoglycerate kinase 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Muscle (RPKM 4387.2), Heart (RPKM 1744.3) and 7 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Pgk1 in Genome Data Viewer
Location:
Xq22
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (75336988..75352962)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (71271454..71287429)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (77263399..77279373)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene toll-like receptor 13 Neighboring gene ribosomal protein L19, pseudogene 17 Neighboring gene TATA-box binding protein associated factor 9b Neighboring gene 40S ribosomal protein S21-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC105265

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ADP binding  
enables ADP binding PubMed 
enables ATP binding  
enables ATP binding  
enables ATP binding PubMed 
enables ATP binding  
enables phosphoglycerate kinase activity  
enables phosphoglycerate kinase activity PubMed 
enables phosphoglycerate kinase activity  
enables phosphoglycerate kinase activity PubMed 
enables phosphoglycerate kinase activity  
enables phosphoglycerate kinase activity  
enables protein serine/threonine kinase activity  
enables protein-disulfide reductase (NAD(P)H) activity  
Process Evidence Code Pubs
involved_in canonical glycolysis  
involved_in cellular response to hypoxia  
involved_in epithelial cell differentiation  
involved_in gluconeogenesis  
involved_in gluconeogenesis PubMed 
involved_in gluconeogenesis PubMed 
involved_in gluconeogenesis  
involved_in glycolytic process  
involved_in glycolytic process PubMed 
involved_in glycolytic process  
involved_in glycolytic process PubMed 
acts_upstream_of_or_within glycolytic process  
involved_in glycolytic process  
involved_in negative regulation of acetyl-CoA biosynthetic process from pyruvate  
involved_in negative regulation of angiogenesis  
involved_in plasminogen activation  
Component Evidence Code Pubs
located_in cytoplasm  
is_active_in cytosol  
is_active_in cytosol  
located_in cytosol  
located_in cytosol  
located_in extracellular space  
located_in membrane raft  
located_in mitochondrial matrix  
located_in mitochondrial matrix  

General protein information

Preferred Names
phosphoglycerate kinase 1
NP_445743.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053291.3NP_445743.2  phosphoglycerate kinase 1

    See identical proteins and their annotated locations for NP_445743.2

    Status: VALIDATED

    Source sequence(s)
    BC087651
    UniProtKB/Swiss-Prot
    P16617, Q5M945, Q6P508
    UniProtKB/TrEMBL
    A0A096MJL6, A6IV43
    Related
    ENSRNOP00000073614.3, ENSRNOT00000085653.3
    Conserved Domains (1) summary
    PTZ00005
    Location:3416
    PTZ00005; phosphoglycerate kinase; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    75336988..75352962
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
External link. Please review our privacy policy.