Pgam1 phosphoglycerate mutase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pgam1provided by RGD
Official Full Name: phosphoglycerate mutase 1provided by RGD
Primary source: RGD:3312
See related: Ensembl:ENSRNOG00000050585 AllianceGenome:RGD:3312
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pgmut; PGAM-B
Summary: Enables phosphoglycerate mutase activity. Predicted to be involved in glycolytic process; regulation of generation of precursor metabolites and energy; and respiratory burst. Located in nucleus. Orthologous to several human genes including PGAM1 (phosphoglycerate mutase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 2509.6), Brain (RPKM 1350.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (250673152..250680762)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (240723832..240731443)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (261158204..261165814)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show statistically significant altered levels of Tpi1 and alteration of Hk1, Aldoc, Pgam1 and Gapdh with borderline significance in phencyclidine (PCP) rats compared to controls.
Title: The application of selective reaction monitoring confirms dysregulation of glycolysis in a preclinical model of schizophrenia.
The cellular localization of phosphoglycerate mutase (PGAM1) type B in the endothelium of the capillaries and arteries of the brain, liver and kidneys was determined by immunocytochemistry.
Title: Immunohistochemical localization of Phosphoglycerate mutase in capillary endothelium of the brain and periphery.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity	ISO Inferred from Sequence Orthology more info
enables 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity	ISS Inferred from Sequence or Structural Similarity more info
enables bisphosphoglycerate mutase activity	ISO Inferred from Sequence Orthology more info
enables bisphosphoglycerate mutase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphoglycerate mutase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoglycerate mutase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in canonical glycolysis	ISO Inferred from Sequence Orthology more info
involved_in gluconeogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphoglycerate mutase 1

Names: BPG-dependent PGAM 1; phosphoglycerate mutase 1 (brain); phosphoglycerate mutase isozyme B

NP_445742.2

EC 5.4.2.11

EC 5.4.2.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053290.4 → NP_445742.2 phosphoglycerate mutase 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P25113, Q6P0K6

UniProtKB/TrEMBL

A6JH90

Related

ENSRNOP00000065690.1, ENSRNOT00000071965.3

Conserved Domains (1) summary

PRK14115
Location:4 → 253

gpmA; 2,3-diphosphoglycerate-dependent phosphoglycerate mutase