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Pdp2 pyruvate dehydrogenase phosphatase catalytic subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 246311, updated on 11-Apr-2024

Summary

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Official Symbol
Pdp2provided by RGD
Official Full Name
pyruvate dehydrogenase phosphatase catalytic subunit 2provided by RGD
Primary source
RGD:628812
See related
Ensembl:ENSRNOG00000012343 AllianceGenome:RGD:628812
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables protein serine/threonine phosphatase activity. Involved in peptidyl-threonine dephosphorylation and response to starvation. Located in mitochondrion. Orthologous to human PDP2 (pyruvate dehyrogenase phosphatase catalytic subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 376.4), Liver (RPKM 172.4) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
19p14
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (392858..400529, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (386408..394068, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (597427..601556, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene RRAD, Ras related glycolysis inhibitor and calcium channel regulator Neighboring gene cadherin 16 Neighboring gene uncharacterized LOC120098574 Neighboring gene uncharacterized LOC134483518 Neighboring gene carbonic anhydrase 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Starvation and diabetes reduce the amount of pyruvate dehydrogenase phosphatase in rat heart and kidney. Huang B, et al. Diabetes, 2003 Jun. PMID 12765946, Free PMC Article
  2. Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation. Huang B, et al. J Biol Chem, 1998 Jul 10. PMID 9651365
  3. Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer. Roche TE, et al. Cell Mol Life Sci, 2007 Apr. PMID 17310282
  4. Ppm1E is an in cellulo AMP-activated protein kinase phosphatase. Voss M, et al. Cell Signal, 2011 Jan. PMID 20801214
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Starvation and diabetes reduce the amount of this enzyme in heart and kidney.
    Title: Starvation and diabetes reduce the amount of pyruvate dehydrogenase phosphatase in rat heart and kidney.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables [pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in T-helper cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in T-helper cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial; pyruvate dehydrogenase [acetyl-transferring]-phosphatase 2, mitochondrial
Names
PDP 2
PDPC 2
pyruvate dehydrogenase phosphatase isoenzyme 2
pyruvate dehyrogenase phosphatase catalytic subunit 2
NP_659559.2
XP_006255110.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145091.4 → NP_659559.2  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_659559.2

    Status: VALIDATED

    Source sequence(s)
    BC072485
    UniProtKB/Swiss-Prot
    A0A0G2JSL7, O88484, Q6IN27
    UniProtKB/TrEMBL
    A6JXU9
    Related
    ENSRNOP00000016462.2, ENSRNOT00000016462.6
    Conserved Domains (1) summary
    smart00332
    Location:96 → 516
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    392858..400529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006255048.5 → XP_006255110.1  pyruvate dehydrogenase [acetyl-transferring]-phosphatase 2, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006255110.1

    UniProtKB/Swiss-Prot
    A0A0G2JSL7, O88484, Q6IN27
    UniProtKB/TrEMBL
    A6JXU9
    Conserved Domains (1) summary
    smart00332
    Location:96 → 516
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88484.2 GenPept UniProtKB/Swiss-Prot:O88484

Gene LinkOut

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