Csad cysteine sulfinic acid decarboxylase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Csadprovided by MGI
Official Full Name: cysteine sulfinic acid decarboxylaseprovided by MGI
Primary source: MGI:MGI:2180098
See related: Ensembl:ENSMUSG00000023044 AllianceGenome:MGI:2180098
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Csd
Summary: Predicted to enable sulfinoalanine decarboxylase activity. Acts upstream of or within taurine biosynthetic process. Predicted to be located in cytoplasm. Is expressed in several structures, including central nervous system; placenta; and sensory organ. Orthologous to human CSAD (cysteine sulfinic acid decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E18 (RPKM 36.1), mammary gland adult (RPKM 27.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F2; 15 57.35 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (102085432..102112685, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (102176997..102205052, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CSAD Ameliorates Lipid Accumulation in High-Fat Diet-Fed Mice.
Title: CSAD Ameliorates Lipid Accumulation in High-Fat Diet-Fed Mice.
taurine biosynthesis in vertebrates involves two structurally related PLP-dependent decarboxylases (cysteine sulfinic acid decarboxylase and glutamic acid decarboxylase like 1)
Title: Mammalian CSAD and GADL1 have distinct biochemical properties and patterns of brain expression.
Estradiol decreases taurine concentration mainly via the reduction of cysteine sulfinic acid decarboxylase expression level through the ER-alpha.
Title: Estradiol decreases taurine level by reducing cysteine sulfinic acid decarboxylase via the estrogen receptor-α in female mice liver.
The results show that CSD is expressed both at the mRNA and protein levels in the testis, epididymis and ductus deferens.
Title: Expression of cysteine sulfinate decarboxylase (CSD) in male reproductive organs of mice.
cDNA sequence that predicts a polypeptide of 493 amino acids - both sequences given
Title: Cloning of murine cysteine sulfinic acid decarboxylase and its mRNA expression in murine tissues.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Csad (e-PCR), detects polymorphism
- UniSTS:479087

Csad (e-PCR), detects polymorphism
- UniSTS:516471

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aspartate 1-decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables carbon-carbon lyase activity	IEA Inferred from Electronic Annotation more info
enables carboxy-lyase activity	TAS Traceable Author Statement more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables sulfinoalanine decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfinoalanine decarboxylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-cysteine catabolic process to hypotaurine	ISO Inferred from Sequence Orthology more info
involved_in L-cysteine catabolic process to taurine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within L-cysteine catabolic process to taurine	TAS Traceable Author Statement more info	PubMed
involved_in carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in taurine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within taurine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within taurine metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cysteine sulfinic acid decarboxylase

Names: aspartate 1-decarboxylase; cysteine-sulfinate decarboxylase; sulfinoalanine decarboxylase

NP_001346055.1

EC 4.1.1.11

EC 4.1.1.29

NP_001346056.1

EC 4.1.1.11

EC 4.1.1.29

NP_001346057.1

EC 4.1.1.11

EC 4.1.1.29

NP_001403380.1

EC 4.1.1.11

EC 4.1.1.29

NP_001403381.1

EC 4.1.1.11

EC 4.1.1.29

NP_001403382.1

EC 4.1.1.11

EC 4.1.1.29

NP_001403383.1

EC 4.1.1.11

EC 4.1.1.29

NP_001403384.1

EC 4.1.1.11

EC 4.1.1.29

NP_001403385.1

EC 4.1.1.11

EC 4.1.1.29

NP_001403386.1

EC 4.1.1.11

EC 4.1.1.29

NP_001403387.1

EC 4.1.1.11

EC 4.1.1.29

NP_001403388.1

EC 4.1.1.11

EC 4.1.1.29

NP_001403389.1

EC 4.1.1.11

EC 4.1.1.29

NP_001403390.1

EC 4.1.1.11

EC 4.1.1.29

NP_001403391.1

EC 4.1.1.11

EC 4.1.1.29

NP_001403392.1

EC 4.1.1.11

EC 4.1.1.29

NP_001403393.1

EC 4.1.1.11

EC 4.1.1.29

NP_001403394.1

EC 4.1.1.11

EC 4.1.1.29

NP_001403395.1

EC 4.1.1.11

EC 4.1.1.29

NP_001403396.1

EC 4.1.1.11

EC 4.1.1.29

NP_001403397.1

EC 4.1.1.11

EC 4.1.1.29

NP_001403398.1

EC 4.1.1.11

EC 4.1.1.29

NP_001403399.1

EC 4.1.1.11

EC 4.1.1.29

NP_001403400.1

EC 4.1.1.11

EC 4.1.1.29

NP_001403401.1

EC 4.1.1.11

EC 4.1.1.29

NP_001403402.1

EC 4.1.1.11

EC 4.1.1.29

NP_001403403.1

EC 4.1.1.11

EC 4.1.1.29

NP_001403404.1

EC 4.1.1.11

EC 4.1.1.29

NP_659191.1

EC 4.1.1.11

EC 4.1.1.29

XP_030104442.1

EC 4.1.1.11

EC 4.1.1.29

XP_030104445.1

EC 4.1.1.11

EC 4.1.1.29

XP_030104446.1

EC 4.1.1.11

EC 4.1.1.29

XP_036015310.1

EC 4.1.1.11

EC 4.1.1.29

XP_036015312.1

EC 4.1.1.11

EC 4.1.1.29

XP_036015314.1

EC 4.1.1.11

EC 4.1.1.29

XP_036015316.1

EC 4.1.1.11

EC 4.1.1.29

XP_036015317.1

EC 4.1.1.11

EC 4.1.1.29

XP_036015318.1

EC 4.1.1.11

EC 4.1.1.29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359126.2 → NP_001346055.1 cysteine sulfinic acid decarboxylase isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC123791

Consensus CDS

CCDS27873.1

UniProtKB/Swiss-Prot

Q8K566, Q9DBE0

Conserved Domains (1) summary

cd06450
Location:89 → 481

DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
NM_001359127.1 → NP_001346056.1 cysteine sulfinic acid decarboxylase isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. This results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AC123791

Conserved Domains (1) summary

cl18945
Location:49 → 382

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
NM_001359128.2 → NP_001346057.1 cysteine sulfinic acid decarboxylase isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks exons in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AC123791

Conserved Domains (1) summary

cl18945
Location:49 → 382

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
NM_001416451.1 → NP_001403380.1 cysteine sulfinic acid decarboxylase isoform 1

Status: VALIDATED

Source sequence(s)

AC123791

UniProtKB/Swiss-Prot

Q8K566, Q9DBE0
NM_001416452.1 → NP_001403381.1 cysteine sulfinic acid decarboxylase isoform 1

Status: VALIDATED

Source sequence(s)

AC123791

UniProtKB/Swiss-Prot

Q8K566, Q9DBE0
NM_001416453.1 → NP_001403382.1 cysteine sulfinic acid decarboxylase isoform 1

Status: VALIDATED

Source sequence(s)

AC123791

UniProtKB/Swiss-Prot

Q8K566, Q9DBE0
NM_001416454.1 → NP_001403383.1 cysteine sulfinic acid decarboxylase isoform 1

Status: VALIDATED

Source sequence(s)

AC123791

UniProtKB/Swiss-Prot

Q8K566, Q9DBE0
NM_001416455.1 → NP_001403384.1 cysteine sulfinic acid decarboxylase isoform 1

Status: VALIDATED

Source sequence(s)

AC123791

UniProtKB/Swiss-Prot

Q8K566, Q9DBE0
NM_001416456.1 → NP_001403385.1 cysteine sulfinic acid decarboxylase isoform 1

Status: VALIDATED

Source sequence(s)

AC123791

UniProtKB/Swiss-Prot

Q8K566, Q9DBE0
NM_001416457.1 → NP_001403386.1 cysteine sulfinic acid decarboxylase isoform 1

Status: VALIDATED

Source sequence(s)

AC123791

UniProtKB/Swiss-Prot

Q8K566, Q9DBE0
NM_001416458.1 → NP_001403387.1 cysteine sulfinic acid decarboxylase isoform 1

Status: VALIDATED

Source sequence(s)

AC123791

UniProtKB/Swiss-Prot

Q8K566, Q9DBE0
NM_001416459.1 → NP_001403388.1 cysteine sulfinic acid decarboxylase isoform 1

Status: VALIDATED

Source sequence(s)

AC123791

UniProtKB/Swiss-Prot

Q8K566, Q9DBE0
NM_001416460.1 → NP_001403389.1 cysteine sulfinic acid decarboxylase isoform 1

Status: VALIDATED

Source sequence(s)

AC123791

UniProtKB/Swiss-Prot

Q8K566, Q9DBE0
NM_001416461.1 → NP_001403390.1 cysteine sulfinic acid decarboxylase isoform 1

Status: VALIDATED

Source sequence(s)

AC123791

UniProtKB/Swiss-Prot

Q8K566, Q9DBE0
NM_001416462.1 → NP_001403391.1 cysteine sulfinic acid decarboxylase isoform 1

Status: VALIDATED

Source sequence(s)

AC123791

UniProtKB/Swiss-Prot

Q8K566, Q9DBE0
NM_001416463.1 → NP_001403392.1 cysteine sulfinic acid decarboxylase isoform 3

Status: VALIDATED

Source sequence(s)

AC123791

UniProtKB/TrEMBL

A0A2R8VHX0
NM_001416464.1 → NP_001403393.1 cysteine sulfinic acid decarboxylase isoform 3

Status: VALIDATED

Source sequence(s)

AC123791

UniProtKB/TrEMBL

A0A2R8VHX0

Related

ENSMUSP00000155492.2, ENSMUST00000230288.2
NM_001416465.1 → NP_001403394.1 cysteine sulfinic acid decarboxylase isoform 3

Status: VALIDATED

Source sequence(s)

AC123791

UniProtKB/TrEMBL

A0A2R8VHX0
NM_001416466.1 → NP_001403395.1 cysteine sulfinic acid decarboxylase isoform 3

Status: VALIDATED

Source sequence(s)

AC123791

UniProtKB/TrEMBL

A0A2R8VHX0
NM_001416467.1 → NP_001403396.1 cysteine sulfinic acid decarboxylase isoform 3

Status: VALIDATED

Source sequence(s)

AC123791

UniProtKB/TrEMBL

A0A2R8VHX0
NM_001416468.1 → NP_001403397.1 cysteine sulfinic acid decarboxylase isoform 4

Status: VALIDATED

Source sequence(s)

AC123791
NM_001416469.1 → NP_001403398.1 cysteine sulfinic acid decarboxylase isoform 4

Status: VALIDATED

Source sequence(s)

AC123791
NM_001416470.1 → NP_001403399.1 cysteine sulfinic acid decarboxylase isoform 2

Status: VALIDATED

Source sequence(s)

AC123791
NM_001416471.1 → NP_001403400.1 cysteine sulfinic acid decarboxylase isoform 5

Status: VALIDATED

Source sequence(s)

AC123791
NM_001416472.1 → NP_001403401.1 cysteine sulfinic acid decarboxylase isoform 2

Status: VALIDATED

Source sequence(s)

AC123791
NM_001416473.1 → NP_001403402.1 cysteine sulfinic acid decarboxylase isoform 6

Status: VALIDATED

Source sequence(s)

AC123791
NM_001416474.1 → NP_001403403.1 cysteine sulfinic acid decarboxylase isoform 6

Status: VALIDATED

Source sequence(s)

AC123791
NM_001416475.1 → NP_001403404.1 cysteine sulfinic acid decarboxylase isoform 5

Status: VALIDATED

Source sequence(s)

AC123791
NM_144942.4 → NP_659191.1 cysteine sulfinic acid decarboxylase isoform 1

See identical proteins and their annotated locations for NP_659191.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC123791

Consensus CDS

CCDS27873.1

UniProtKB/Swiss-Prot

Q8K566, Q9DBE0

Related

ENSMUSP00000023805.2, ENSMUST00000023805.3

Conserved Domains (1) summary

cd06450
Location:89 → 481

DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

RNA

NR_183985.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC123791
NR_183986.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC123791
NR_183987.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC123791

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

102085432..102112685 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030248585.1 → XP_030104445.1 cysteine sulfinic acid decarboxylase isoform X3

Conserved Domains (1) summary

cl18945
Location:49 → 382

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
XM_036159419.1 → XP_036015312.1 cysteine sulfinic acid decarboxylase isoform X1

UniProtKB/Swiss-Prot

Q8K566, Q9DBE0

Conserved Domains (1) summary

cd06450
Location:89 → 481

DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
XM_036159424.1 → XP_036015317.1 cysteine sulfinic acid decarboxylase isoform X2

UniProtKB/TrEMBL

A0A2R8VHX0

Conserved Domains (1) summary

cd06450
Location:89 → 451

DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
XM_036159423.1 → XP_036015316.1 cysteine sulfinic acid decarboxylase isoform X2

UniProtKB/TrEMBL

A0A2R8VHX0

Conserved Domains (1) summary

cd06450
Location:89 → 451

DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
XM_036159425.1 → XP_036015318.1 cysteine sulfinic acid decarboxylase isoform X3

Conserved Domains (1) summary

cl18945
Location:49 → 382

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
XM_036159421.1 → XP_036015314.1 cysteine sulfinic acid decarboxylase isoform X1

UniProtKB/Swiss-Prot

Q8K566, Q9DBE0

Conserved Domains (1) summary

cd06450
Location:89 → 481

DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
XM_036159417.1 → XP_036015310.1 cysteine sulfinic acid decarboxylase isoform X1

UniProtKB/Swiss-Prot

Q8K566, Q9DBE0

Conserved Domains (1) summary

cd06450
Location:89 → 481

DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
XM_030248582.2 → XP_030104442.1 cysteine sulfinic acid decarboxylase isoform X2

UniProtKB/TrEMBL

A0A2R8VHX0

Conserved Domains (1) summary

cd06450
Location:89 → 451

DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
XM_030248586.2 → XP_030104446.1 cysteine sulfinic acid decarboxylase isoform X4

Conserved Domains (1) summary

cl18945
Location:49 → 382

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...