Retn resistin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Retnprovided by RGD
Official Full Name: resistinprovided by RGD
Primary source: RGD:628781
See related: Ensembl:ENSRNOG00000001001 AllianceGenome:RGD:628781
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable hormone activity. Involved in several processes, including positive regulation of cell communication; positive regulation of smooth muscle cell migration; and positive regulation of smooth muscle cell proliferation. Located in extracellular space and nucleus. Used to study colitis. Biomarker of non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in hypertension; hypertrophic cardiomyopathy; obesity; and type 2 diabetes mellitus. Orthologous to human RETN (resistin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 239.8), Adrenal (RPKM 205.8) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12p12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (6508653..6511115)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (1710881..1712621)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (2201909..2203649)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Resistin Is Increased in Periodontal Cells and Tissues: In Vitro and In Vivo Studies.
Title: Resistin Is Increased in Periodontal Cells and Tissues: In Vitro and In Vivo Studies.
Relation between resistin, PPAR-gamma, obesity and atherosclerosis in male albino rats.
Title: Relation between resistin, PPAR-γ, obesity and atherosclerosis in male albino rats.
Resistin Mediates Sex-Dependent Effects of Perivascular Adipose Tissue on Vascular Function in the Shrsp.
Title: Resistin Mediates Sex-Dependent Effects of Perivascular Adipose Tissue on Vascular Function in the Shrsp.
Significant correlations were observed between PGC-1alpha gene expression and serum concentrations of irisin, nesfatin-1 and resistin. beta-hydroxy-beta-methylbutyrate free acid supplementation with eccentric resistance training may induce crosstalk between peptide release from other tissues and increases maximal muscle strength. The combination of the two interventions had a more substantial effect than each in isolat...
Title: Eccentric resistance training and β-hydroxy-β-methylbutyrate free acid affects muscle PGC-1α expression and serum irisin, nesfatin-1 and resistin in rats.
High RETN expression is associated with hypothalamic inflammation and increases insulin resistance.
Title: Central s-resistin deficiency ameliorates hypothalamic inflammation and increases whole body insulin sensitivity.
Adiponectin and resistin did not correlate with the large effect of maternal-neonatal separation on adult insulin resistance.
Title: Insulin sensitivity, leptin, adiponectin, resistin, and testosterone in adult male and female rats after maternal-neonatal separation and environmental stress.
We identified resistin immunoreactivity in the periphery of rat pancreatic islets and confirmed the expression of resistin at mRNA and protein level. Obtained data indicated that resistin is co-localized with glucagon in pancreatic alpha-cells.
Title: Resistin is produced by rat pancreatic islets and regulates insulin and glucagon in vitro secretion.
The results of the present study showed that resistin increased the production of the TNFalpha and IL6 proinflammatory cytokines via the NFkappaBdependent pathway during acute pancreatitis.
Title: Resistin aggravates the expression of proinflammatory cytokines in cerulein‑stimulated AR42J pancreatic acinar cells.
Sitagliptin attenuated resistin expression via the GIP-dependent pathway, which inhibited sympathetic innervation through a signalling pathway involving phosphatidylinositol 3-kinase (PI3K) and Akt protein.
Title: Sitagliptin decreases ventricular arrhythmias by attenuated glucose-dependent insulinotropic polypeptide (GIP)-dependent resistin signalling in infarcted rats.
Resistin may play an important role in the process of insulin resistance in rats with traumatic brain injury.
Title: Resistin expression in adipose tissues and its effect on glucose metabolism in rats with brain injury.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of feeding behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of collagen metabolic process	IMP Inferred from Mutant Phenotype more info
involved_in positive regulation of progesterone secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info
involved_in positive regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info
involved_in positive regulation of synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in response to insulin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: resistin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.