ptgs1 prostaglandin-endoperoxide synthase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ptgs1provided by ZNC
Official Full Name: prostaglandin-endoperoxide synthase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-020530-1
See related: Ensembl:ENSDARG00000052148 AllianceGenome:ZFIN:ZDB-GENE-020530-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cox1; zCOX-1
Summary: Enables peroxidase activity and prostaglandin-endoperoxide synthase activity. Acts upstream of or within animal organ development; cellular response to organic cyclic compound; and vasculogenesis. Predicted to be active in cytoplasm and neuron projection. Is expressed in several structures, including cardiovascular system; digestive system; eye; mesoderm; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human PTGS1 (prostaglandin-endoperoxide synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (64907368..64946436)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (64226204..64265272)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ptgs1-/- ptgs2a-/- double mutant female zebrafish were infertile due to ovulation failure; knockdown of ptgs2b in ptgs1-/- ptgs2a-/- double mutant embryos induced severe defects in the formation of connecting cilia and photoreceptor cell development
Title: Photoreceptor cell development requires prostaglandin signaling in the zebrafish retina.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables peroxidase activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin-endoperoxide synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin-endoperoxide synthase activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin-endoperoxide synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
involved_in cyclooxygenase pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within exocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pronephros development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: prostaglandin G/H synthase 1

Names: Cox-1; Cox-1b

NP_705942.1

EC 1.14.99.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153656.2 → NP_705942.1 prostaglandin G/H synthase 1 precursor

See identical proteins and their annotated locations for NP_705942.1

Status: PROVISIONAL

Source sequence(s)

AY028584

UniProtKB/TrEMBL

Q8JH44

Related

ENSDARP00000104772.2, ENSDART00000122863.3

Conserved Domains (2) summary

cd09816
Location:90 → 576

prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins

pfam00008
Location:36 → 68

EGF; EGF-like domain