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Akap9 A-kinase anchoring protein 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 246150, updated on 13-Apr-2024

Summary

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Official Symbol
Akap9provided by RGD
Official Full Name
A-kinase anchoring protein 9provided by RGD
Primary source
RGD:620833
See related
Ensembl:ENSRNOG00000026319 AllianceGenome:RGD:620833
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gisp; CG-NAP; Yotiao
Summary
Enables protein kinase A regulatory subunit binding activity. Involved in negative regulation of adenylate cyclase activity and response to electrical stimulus. Located in dendritic branch; neuronal cell body; and synaptic membrane. Is extrinsic component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in long QT syndrome 11. Orthologous to human AKAP9 (A-kinase anchoring protein 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 257.0), Heart (RPKM 188.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Akap9 in Genome Data Viewer
Location:
4q13
Exon count:
52
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (31011475..31147338, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (30056738..30192716, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (27195346..27331582, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486558 Neighboring gene cytochrome P450, family 51 Neighboring gene uncharacterized histidine-rich protein DDB_G0274557-like Neighboring gene uncharacterized LOC134486559 Neighboring gene mitochondrial transcription termination factor 1 Neighboring gene leucine-rich repeats and death domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. AKAP9 supports spermatogenesis through its effects on microtubule and actin cytoskeletons in the rat testis. Wu S, et al. FASEB J, 2021 Oct. PMID 34569663
  2. GISP increases neurotransmitter receptor stability by down-regulating ESCRT-mediated lysosomal degradation. Kantamneni S, et al. Neurosci Lett, 2009 Mar 13. PMID 19154774, Free PMC Article
  3. The A-kinase anchoring protein Yotiao binds and regulates adenylyl cyclase in brain. Piggott LA, et al. Proc Natl Acad Sci U S A, 2008 Sep 16. PMID 18772391, Free PMC Article
  4. GISP: a novel brain-specific protein that promotes surface expression and function of GABA(B) receptors. Kantamneni S, et al. J Neurochem, 2007 Feb. PMID 17241134, Free PMC Article
  5. Junctional membrane inositol 1,4,5-trisphosphate receptor complex coordinates sensitization of the silent EGF-induced Ca2+ signaling. Hur EM, et al. J Cell Biol, 2005 May 23. PMID 15911880, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AKAP9 supports spermatogenesis through its effects on microtubule and actin cytoskeletons in the rat testis.
    Title: AKAP9 supports spermatogenesis through its effects on microtubule and actin cytoskeletons in the rat testis.
  2. These data suggest that GISP is a novel neuronal SUMO substrate whose SUMOylation status is modulated by neuronal activity.
    Title: Activity-dependent SUMOylation of the brain-specific scaffolding protein GISP.
  3. InsP3R1 forms a complex with AKAP450 and PKAIIbeta, localized in the Golgi apparatus of cerebellar granule cells.
    Title: Ins(1,4,5)P3 receptor type 1 associates with AKAP9 (AKAP450 variant) and protein kinase A type IIbeta in the Golgi apparatus in cerebellar granule cells.
  4. GISP acts as a negative regulator of TSG101-dependent lysosomal degradation and plays an important role in determining the availability of neurotransmitter receptors.
    Title: GISP increases neurotransmitter receptor stability by down-regulating ESCRT-mediated lysosomal degradation.
  5. These data suggest that GISP can function as a negative regulator of TSG101-dependent lysosomal degradation of transmembrane proteins in neurons to promote receptor stability.
    Title: GISP binding to TSG101 increases GABA receptor stability by down-regulating ESCRT-mediated lysosomal degradation.
  6. GISP is involved in the forward trafficking and stabilization of functional GABA(B)Rs.
    Title: GISP: a novel brain-specific protein that promotes surface expression and function of GABA(B) receptors.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase A regulatory subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase A regulatory subunit binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase A regulatory subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Sertoli cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
  
involved_in maintenance of centrosome location IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maintenance of centrosome location ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule nucleation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of potassium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein-containing complex localization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cardiac muscle cell action potential involved in regulation of contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of heart rate by cardiac conduction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of membrane repolarization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ventricular cardiac muscle cell membrane repolarization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of ventricular cardiac muscle cell membrane repolarization ISO
Inferred from Sequence Orthology
more info
  
involved_in response to electrical stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in 9+2 motile cilium ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in Golgi stack IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi stack ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
is_active_in cis-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cis-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic branch IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extrinsic component of postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pericentriolar material ISO
Inferred from Sequence Orthology
more info
  
part_of potassium channel complex ISO
Inferred from Sequence Orthology
more info
  
located_in subapical part of cell ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
A-kinase anchor protein 9
Names
A kinase (PRKA) anchor protein (yotiao) 9
A kinase (PRKA) anchor protein 9
GABA-B receptor-interacting scaffolding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037093.2 → NP_001032170.2  A-kinase anchor protein 9

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I6AIG6, F1LPB4
    Related
    ENSRNOP00000010118.5, ENSRNOT00000010118.7
    Conserved Domains (2) summary
    TIGR02168
    Location:131 → 860
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10495
    Location:3569 → 3650
    PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    31011475..31147338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285532.1 → XP_063141602.1  A-kinase anchor protein 9 isoform X12

  2. XM_006236025.4 → XP_006236087.1  A-kinase anchor protein 9 isoform X8

    UniProtKB/TrEMBL
    A0A8I6AIG6, A0A8I6GHX5
    Related
    ENSRNOP00000089245.1
    Conserved Domains (2) summary
    TIGR02168
    Location:131 → 860
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10495
    Location:3614 → 3695
    PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

  3. XM_063285527.1 → XP_063141597.1  A-kinase anchor protein 9 isoform X6

  4. XM_017592446.3 → XP_017447935.1  A-kinase anchor protein 9 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AIG6

  5. XM_063285531.1 → XP_063141601.1  A-kinase anchor protein 9 isoform X11

    UniProtKB/TrEMBL
    A0A8I5ZWI9

  6. XM_063285530.1 → XP_063141600.1  A-kinase anchor protein 9 isoform X10

  7. XM_006236023.5 → XP_006236085.1  A-kinase anchor protein 9 isoform X5

    See identical proteins and their annotated locations for XP_006236085.1

    UniProtKB/TrEMBL
    A0A8I6AIG6, A6K272
    Related
    ENSRNOP00000084102.1
    Conserved Domains (2) summary
    TIGR02168
    Location:149 → 878
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10495
    Location:3632 → 3713
    PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

  8. XM_017592447.3 → XP_017447936.1  A-kinase anchor protein 9 isoform X4

    UniProtKB/TrEMBL
    A0A0G2K548, A0A8I6AIG6
    Related
    ENSRNOP00000073290.1

  9. XM_063285528.1 → XP_063141598.1  A-kinase anchor protein 9 isoform X9

  10. XM_017592448.3 → XP_017447937.1  A-kinase anchor protein 9 isoform X7

    UniProtKB/TrEMBL
    A0A8I6AIG6

  11. XM_008762686.4 → XP_008760908.1  A-kinase anchor protein 9 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AIG6
    Conserved Domains (2) summary
    TIGR02168
    Location:149 → 878
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10495
    Location:3657 → 3738
    PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

  12. XM_008762685.4 → XP_008760907.1  A-kinase anchor protein 9 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AIG6
    Conserved Domains (2) summary
    TIGR02168
    Location:149 → 878
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10495
    Location:3670 → 3751
    PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein

  13. XM_063285533.1 → XP_063141603.1  A-kinase anchor protein 9 isoform X13

Nucleotide Protein Strain
Heading Accession and Version

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