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Gng8 G protein subunit gamma 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 245986, updated on 13-Apr-2024

Summary

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Official Symbol
Gng8provided by RGD
Official Full Name
G protein subunit gamma 8provided by RGD
Primary source
RGD:620808
See related
Ensembl:ENSRNOG00000016701 AllianceGenome:RGD:620808
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hg3e
Summary
Predicted to enable G-protein beta-subunit binding activity. Involved in nervous system development. Predicted to be part of heterotrimeric G-protein complex. Orthologous to human GNG8 (G protein subunit gamma 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 118.3), Spleen (RPKM 28.6) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gng8 in Genome Data Viewer
Location:
1q21
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (86692609..86696463)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (77564512..77568371)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (78818360..78822224)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene protein kinase D2 Neighboring gene transfer RNA proline (anticodon CGG) Neighboring gene dishevelled-binding antagonist of beta-catenin 3 Neighboring gene prostaglandin I2 receptor Neighboring gene calmodulin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel GTP-binding protein gamma-subunit, G gamma 8, is expressed during neurogenesis in the olfactory and vomeronasal neuroepithelia. Ryba NJ, et al. J Biol Chem, 1995 Mar 24. PMID 7896821
  2. Aggressive behaviour and physiological responses to pheromones are strongly impaired in mice deficient for the olfactory G-protein -subunit G8. Montani G, et al. J Physiol, 2013 Aug 15. PMID 23836683, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G-protein beta-subunit binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to pheromone ISO
Inferred from Sequence Orthology
more info
  
involved_in nervous system development IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within nose development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within social behavior ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of heterotrimeric G-protein complex IEA
Inferred from Electronic Annotation
more info
  
part_of heterotrimeric G-protein complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
Names
G-protein gamma 8 subunit
gamma-9
guanine nucleotide binding protein (G protein), gamma 8 subunit
heterotrimeric guanine nucleotide-binding protein 3e

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139185.2 → NP_631924.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

    See identical proteins and their annotated locations for NP_631924.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P63077
    UniProtKB/TrEMBL
    A6J8D6
    Conserved Domains (1) summary
    smart00224
    Location:8 → 70
    GGL; G protein gamma subunit-like motifs

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    86692609..86696463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098799.2 → XP_038954727.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1

    UniProtKB/Swiss-Prot
    P63077
    UniProtKB/TrEMBL
    A6J8D6
    Related
    ENSRNOP00000072099.1
    Conserved Domains (1) summary
    smart00224
    Location:8 → 70
    GGL; G protein gamma subunit-like motifs

  2. XM_006228384.5 → XP_006228446.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1

    See identical proteins and their annotated locations for XP_006228446.1

    UniProtKB/Swiss-Prot
    P63077
    UniProtKB/TrEMBL
    A6J8D6
    Conserved Domains (1) summary
    smart00224
    Location:8 → 70
    GGL; G protein gamma subunit-like motifs
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63077.1 GenPept UniProtKB/Swiss-Prot:P63077

Gene LinkOut

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