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Magi3 membrane associated guanylate kinase, WW and PDZ domain containing 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 245903, updated on 11-Apr-2024

Summary

Official Symbol
Magi3provided by RGD
Official Full Name
membrane associated guanylate kinase, WW and PDZ domain containing 3provided by RGD
Primary source
RGD:621362
See related
Ensembl:ENSRNOG00000019885 AllianceGenome:RGD:621362
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Slipr
Summary
Predicted to enable frizzled binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within positive regulation of JUN kinase activity. Predicted to be located in cell junction. Predicted to be active in cell-cell junction and cytoplasm. Orthologous to human MAGI3 (membrane associated guanylate kinase, WW and PDZ domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 243.5), Heart (RPKM 144.6) and 9 other tissues See more
Orthologs
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Genomic context

Location:
2q34
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (194206587..194405468, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (191514726..191717048, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (206499467..206699105, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene round spermatid basic protein 1 Neighboring gene uncharacterized LOC134485663 Neighboring gene putative homeodomain transcription factor 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134485759 Neighboring gene uncharacterized LOC108350079 Neighboring gene ribosomal protein L17, pseudogene 14

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables frizzled binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
Names
MAGI-3
membrane-associated guanylate kinase inverted 3
membrane-associated guanylate kinase-related (MAGI-3)
scaffolding protein SLIPR
scaffolding-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139084.3NP_620784.3  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q9JK71
    UniProtKB/TrEMBL
    F1M7S0
    Related
    ENSRNOP00000026952.5, ENSRNOT00000026952.7
    Conserved Domains (6) summary
    smart00228
    Location:729812
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG5021
    Location:211373
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00201
    Location:299329
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:10231101
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    PTZ00112
    Location:11151405
    PTZ00112; origin recognition complex 1 protein; Provisional
    cl17190
    Location:125199
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    194206587..194405468 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101721.2XP_038957649.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9JK71
    Conserved Domains (6) summary
    smart00228
    Location:711794
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG5021
    Location:211373
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00201
    Location:299329
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:10051083
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    PTZ00112
    Location:10971387
    PTZ00112; origin recognition complex 1 protein; Provisional
    cl17190
    Location:125199
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  2. XM_008761367.4XP_008759589.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X2

    See identical proteins and their annotated locations for XP_008759589.1

    UniProtKB/TrEMBL
    A0A8I6AE46
    Related
    ENSRNOP00000090602.1
    Conserved Domains (4) summary
    smart00456
    Location:297329
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:729812
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:10231101
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl17190
    Location:125199
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...