igf1ra insulin-like growth factor 1a receptor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: igf1raprovided by ZNC
Official Full Name: insulin-like growth factor 1a receptorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020503-1
See related: Ensembl:ENSDARG00000027423 AllianceGenome:ZFIN:ZDB-GENE-020503-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: IGF-IRa; sb:eu1090; wu:fi20b10
Summary: Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process and insulin-like growth factor binding activity. Acts upstream of or within several processes, including animal organ development; fin regeneration; and insulin-like growth factor receptor signaling pathway. Predicted to be integral component of membrane. Predicted to be part of insulin receptor complex. Predicted to be active in axon. Predicted to be integral component of plasma membrane. Is expressed in several structures, including digestive system; eye; gill; musculature system; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); kidney cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and neurodegenerative disease (multiple). Orthologous to human IGF1R (insulin like growth factor 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (20882694..21047725, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (20893628..21058700, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that transgenic zebrafish that are dominant-negative for IGF1R exhibit insulin resistant skeletal muscles and altered numbers of insulin-secreting cells; glucose intolerance develops with age after overfeeding.
Title: Skeletal muscle insulin resistance in zebrafish induces alterations in β-cell number and glucose tolerance in an age- and diet-dependent manner.
define the first functional gene set for habituation learning in a vertebrate and identify pregnancy-associated plasma protein-aa-regulated IGF signaling
Title: A genome-wide screen identifies PAPP-AA-mediated IGFR signaling as a novel regulator of habituation learning.
results provide novel insight into the cellular function of IGF1 receptor and show IGF1R signaling does not function as an anteriorizing signal but regulates embryonic growth and development by promoting cell survival and cell cycle progression
Title: Insulin-like growth factor signaling regulates zebrafish embryonic growth and development by promoting cell survival and cell cycle progression.
Duplicated zebrafish ig f1r genes (ig f1ra and ig f1rb)play largely overlapping but not identical functional roles in early development.
Title: Gene duplication and functional divergence of the zebrafish insulin-like growth factor 1 receptors.

Submit: New GeneRIF Correction

General gene information

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Markers

fb09d12.x1 (e-PCR)
- UniSTS:202781

fi20b10.x1 (e-PCR)
- UniSTS:196991

STS-Z40707 (e-PCR)
- UniSTS:72414

G45939 (e-PCR)
- UniSTS:106741

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
enables insulin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables insulin receptor substrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin receptor substrate binding	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor binding	IPI Inferred from Physical Interaction more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chordate embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic camera-type eye development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within fin regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within semicircular canal morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spinal cord motor neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
part_of insulin receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: insulin-like growth factor 1 receptor; insulin-like growth factor 1a receptor

NP_694500.1

EC 2.7.10.1

XP_017207385.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152968.1 → NP_694500.1 insulin-like growth factor 1a receptor precursor

See identical proteins and their annotated locations for NP_694500.1

Status: PROVISIONAL

Source sequence(s)

AF400275

UniProtKB/TrEMBL

A0A8N7UZS2

Related

ENSDARP00000017066.5, ENSDART00000010189.7

Conserved Domains (6) summary

cd05062
Location:990 → 1266

PTKc_IGF-1R; Catalytic domain of the Protein Tyrosine Kinase, Insulin-like Growth Factor-1 Receptor

smart00261
Location:235 → 275

FU; Furin-like repeats

cd00063
Location:844 → 921

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00757
Location:182 → 333

Furin-like; Furin-like cysteine rich region

pfam01030
Location:351 → 465

Recep_L_domain; Receptor L domain

pfam07714
Location:997 → 1264

Pkinase_Tyr; Protein tyrosine kinase