Abcc1 ATP binding cassette subfamily C member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Abcc1provided by RGD
Full Name: ATP binding cassette subfamily C member 1provided by RGD
Primary source: RGD:3112
See related: Ensembl:ENSRNOG00000022305 AllianceGenome:RGD:3112
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mrp; Mrp1; Abcc1a; Avcc1a
Summary: Enables several functions, including ATPase-coupled transmembrane transporter activity; glutathione transmembrane transporter activity; and long-chain fatty acid transporter activity. Involved in several processes, including glutathione transmembrane transport; lipid transport; and xenobiotic detoxification by transmembrane export across the plasma membrane. Located in basolateral plasma membrane and cytoplasm. Is integral component of plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 77 and chronic obstructive pulmonary disease. Orthologous to human ABCC1 (ATP binding cassette subfamily C member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 194.7), Thymus (RPKM 171.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q11

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (1022041..1162431, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (528961..655179, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (549537..672235, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bile Duct Ligation Impairs Function and Expression of Mrp1 at Rat Blood-Retinal Barrier via Bilirubin-Induced P38 MAPK Pathway Activations.
Title: Bile Duct Ligation Impairs Function and Expression of Mrp1 at Rat Blood-Retinal Barrier via Bilirubin-Induced P38 MAPK Pathway Activations.
The ROS-mediated increase in the synthesis of MRP-1 and BCRP can play an important role in hyperoxaluria-promoted calcium oxalate urolithiasis by facilitating phosphatidylserine redistribution in renal epithelial cells.
Title: MRP-1 and BCRP Promote the Externalization of Phosphatidylserine in Oxalate-treated Renal Epithelial Cells: Implications for Calcium Oxalate Urolithiasis.
The data of this study show increased Abcc1, Abcc2, and Abcc4 mRNA expression at the BBB in response to H/R stress and that Abcc gene expression is regulated by Nrf2 signaling.
Title: Nrf2 signaling increases expression of ATP-binding cassette subfamily C mRNA transcripts at the blood-brain barrier following hypoxia-reoxygenation stress.
MRP1 is downregulated in glioma cells by chitosan-MRP1 siRNA nanoparticles
Title: Down-Regulation of MRP1 Expression in C6/VP16 Cells by Chitosan-MRP1-siRNA Nanoparticles.
Sonication enhanced sensitivity of glioma tumor cells to doxorubicin by down-regulating the expressions of p-glycoprotein and multidrug resistance protein 1.
Title: Low intensity ultrasound promotes the sensitivity of rat brain glioma to Doxorubicin by down-regulating the expressions of p-glucoprotein and multidrug resistance protein 1 in vitro and in vivo.
The number of MRP1-positive cells in the cortex and hippocampus was also significantly increased in amygdale kindling rats.
Title: Multidrug resistance-associated protein 1 decreases the concentrations of antiepileptic drugs in cortical extracellular fluid in amygdale kindling rats.
Xifeng Capsule used alone or combined with carbamazepine can effectively inhibit MRP1 expression in hippocampus and cortex of epileptic rats.
Title: [Effects of Chinese herbal medicine Xifeng Capsule on multidrug resistance-associated protein 1 expression in hippocampus and cortex of rats with lithium-pilocarpine-induced epilepsy].
Results show that the presence of Mdr1a, Mdr1b (P-glycoprotein Pgp) and multidrug resistance-associated protein (MRP1) encoding genes in the olfactory mucosa of rat and mouse was confirmed by RT-PCR.
Title: Functional evidence of multidrug resistance transporters (MDR) in rodent olfactory epithelium.
In olfactory epithelium, high levels of expression of xenobiotic transporters Mrp1, Mrp3, Mrp5, Mdr1a, Oatp2 and Oat6 are expressed.
Title: Expression and differential localization of xenobiotic transporters in the rat olfactory neuro-epithelium.
ATP-binding cassette ABCC1 is involved in the release of sphingosine 1-phosphate from rat uterine leiomyoma ELT3 cells and late pregnant rat myometrium
Title: ATP-binding cassette ABCC1 is involved in the release of sphingosine 1-phosphate from rat uterine leiomyoma ELT3 cells and late pregnant rat myometrium.

Submit: New GeneRIF Correction See all GeneRIFs (33)

General gene information

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Markers

AU047602 (e-PCR)
- UniSTS:110346

RH142203 (e-PCR)
- UniSTS:231453

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ABC-type glutathione S-conjugate transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type glutathione S-conjugate transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type glutathione S-conjugate transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ABC-type vitamin B12 transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type vitamin B12 transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type xenobiotic transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ABC-type xenobiotic transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ABC-type xenobiotic transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled lipid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ATPase-coupled lipid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amide transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables carboxylic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables efflux transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables efflux transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables efflux transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables glutathione transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables glutathione transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glutathione transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables xenobiotic transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables xenobiotic transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in astrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carboxylic acid transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amyloid-beta	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
involved_in cobalamin transport	IEA Inferred from Electronic Annotation more info
involved_in cobalamin transport	ISO Inferred from Sequence Orthology more info
involved_in cyclic nucleotide transport	IEA Inferred from Electronic Annotation more info
involved_in cyclic nucleotide transport	ISO Inferred from Sequence Orthology more info
involved_in cyclic nucleotide transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in export across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in export across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glutathione transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in glutathione transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukotriene transport	IEA Inferred from Electronic Annotation more info
involved_in leukotriene transport	ISO Inferred from Sequence Orthology more info
involved_in leukotriene transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in long-chain fatty acid import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipid efflux	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid translocation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cellular response to drug	IDA Inferred from Direct Assay more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in sphingolipid translocation	ISO Inferred from Sequence Orthology more info
involved_in transepithelial transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic transport	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basal plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: multidrug resistance-associated protein 1

Names: ATP-binding cassette sub-family C ( CFTR/MRP) member 1a; ATP-binding cassette sub-family C member 1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; ATP-binding cassette, sub-family C, member 1-like; ATP-binding cassette, subfamily C (CFTR/MRP), member 1; LTC4 transporter; glutathione-S-conjugate-translocating ATPase ABCC1; leukotriene C(4) transporter; multidrug resistance protein 1; multidrug resistance-associated protein 1-like; multiple drug resistance-associated protein

NP_071617.2

EC 7.6.2.2

EC 7.6.2.3

XP_038941121.1

EC 7.6.2.2

EC 7.6.2.3

XP_038941122.1

EC 7.6.2.2

EC 7.6.2.3

XP_063124469.1

EC 7.6.2.2

EC 7.6.2.3

XP_063124470.1

EC 7.6.2.2

EC 7.6.2.3

XP_063124471.1

EC 7.6.2.2

EC 7.6.2.3

XP_063124472.1

EC 7.6.2.2

EC 7.6.2.3

XP_063124473.1

EC 7.6.2.2

EC 7.6.2.3

XP_063124474.1

EC 7.6.2.2

EC 7.6.2.3

XP_063124475.1

EC 7.6.2.2

EC 7.6.2.3

XP_063124476.1

EC 7.6.2.2

EC 7.6.2.3

XP_063124477.1

EC 7.6.2.2

EC 7.6.2.3

XP_063124478.1

EC 7.6.2.2

EC 7.6.2.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022281.3 → NP_071617.2 multidrug resistance-associated protein 1

See identical proteins and their annotated locations for NP_071617.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q63346, Q810E4, Q810G9, Q8CG09, Q9JHS0

UniProtKB/TrEMBL

E9PT28

Related

ENSRNOP00000044445.6, ENSRNOT00000044108.6

Conserved Domains (1) summary

TIGR00957
Location:7 → 1531

MRP_assoc_pro; multi drug resistance-associated protein (MRP)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

1022041..1162431 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063268401.1 → XP_063124471.1 multidrug resistance-associated protein 1 isoform X5
XM_063268404.1 → XP_063124474.1 multidrug resistance-associated protein 1 isoform X8
XM_063268402.1 → XP_063124472.1 multidrug resistance-associated protein 1 isoform X6
XM_063268400.1 → XP_063124470.1 multidrug resistance-associated protein 1 isoform X4
XM_063268399.1 → XP_063124469.1 multidrug resistance-associated protein 1 isoform X3
XM_039085193.2 → XP_038941121.1 multidrug resistance-associated protein 1 isoform X1

UniProtKB/TrEMBL

E9PT28

Conserved Domains (1) summary

TIGR00957
Location:7 → 1528

MRP_assoc_pro; multi drug resistance-associated protein (MRP)
XM_039085194.2 → XP_038941122.1 multidrug resistance-associated protein 1 isoform X2

UniProtKB/TrEMBL

E9PT28

Conserved Domains (1) summary

TIGR00957
Location:7 → 1522

MRP_assoc_pro; multi drug resistance-associated protein (MRP)
XM_063268407.1 → XP_063124477.1 multidrug resistance-associated protein 1 isoform X11
XM_063268406.1 → XP_063124476.1 multidrug resistance-associated protein 1 isoform X10
XM_063268405.1 → XP_063124475.1 multidrug resistance-associated protein 1 isoform X9
XM_063268408.1 → XP_063124478.1 multidrug resistance-associated protein 1 isoform X12
XM_063268403.1 → XP_063124473.1 multidrug resistance-associated protein 1 isoform X7