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Mos MOS proto-oncogene, serine/threonine kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 24559, updated on 7-Jan-2025

Summary

Official Symbol
Mosprovided by RGD
Official Full Name
MOS proto-oncogene, serine/threonine kinaseprovided by RGD
Primary source
RGD:3103
See related
EnsemblRapid:ENSRNOG00000008567 AllianceGenome:RGD:3103
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables protein serine/threonine kinase activity. Predicted to be involved in several processes, including ERK1 and ERK2 cascade; microtubule cytoskeleton organization; and positive regulation of ERK1 and ERK2 cascade. Predicted to act upstream of or within regulation of meiotic nuclear division. Predicted to be active in cytoplasm. Orthologous to human MOS (MOS proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See Mos in Genome Data Viewer
Location:
5q12
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (21657549..21658856, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (16859957..16861264, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (16746085..16747392, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 54 Neighboring gene ribosomal protein S20 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene DnaJ heat shock protein family (Hsp40) member B6, pseudogene 2 Neighboring gene large ribosomal subunit protein eL19-like

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Items 1 - 25 of 27
Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity  
enables AMP-activated protein kinase activity  
enables ATP binding  
enables DNA-dependent protein kinase activity  
enables MAP kinase kinase kinase activity  
enables Rho-dependent protein serine/threonine kinase activity  
enables eukaryotic translation initiation factor 2alpha kinase activity  
enables histone H2AS1 kinase activity  
enables histone H2AS121 kinase activity  
enables histone H2AT120 kinase activity  
enables histone H2AXS139 kinase activity  
enables histone H2BS14 kinase activity  
enables histone H2BS36 kinase activity  
enables histone H3S10 kinase activity  
enables histone H3S28 kinase activity  
enables histone H3S57 kinase activity  
enables histone H3T11 kinase activity  
enables histone H3T3 kinase activity  
enables histone H3T45 kinase activity  
enables histone H3T6 kinase activity  
enables histone H4S1 kinase activity  
enables protein kinase activity  
enables protein kinase activity PubMed 
enables protein serine kinase activity  
enables protein serine/threonine kinase activity PubMed 
enables protein serine/threonine kinase activity  
enables ribosomal protein S6 kinase activity  
Items 1 - 25 of 27
Items 1 - 25 of 33
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade  
involved_in MAPK cascade  
involved_in MAPK cascade  
involved_in chromatin organization  
involved_in chromatin organization  
involved_in chromatin organization  
involved_in chromatin remodeling  
involved_in establishment of meiotic spindle orientation  
involved_in establishment of meiotic spindle orientation  
involved_in establishment of meiotic spindle orientation  
involved_in intracellular signal transduction PubMed 
involved_in meiotic spindle organization  
involved_in meiotic spindle organization  
involved_in meiotic spindle organization  
involved_in negative regulation of metaphase/anaphase transition of meiotic cell cycle  
involved_in negative regulation of metaphase/anaphase transition of meiotic cell cycle  
involved_in negative regulation of metaphase/anaphase transition of meiotic cell cycle  
involved_in negative regulation of metaphase/anaphase transition of meiotic cell cycle  
involved_in oocyte maturation  
involved_in oocyte maturation  
involved_in oocyte maturation  
involved_in positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of MAPK cascade  
involved_in positive regulation of MAPK cascade  
involved_in positive regulation of MAPK cascade  
involved_in protein autophosphorylation  
involved_in protein phosphorylation PubMed 
involved_in regulation of meiotic nuclear division  
acts_upstream_of_or_within regulation of meiotic nuclear division  
involved_in signal transduction  
involved_in spermatogenesis PubMed 
Items 1 - 25 of 33
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytoplasm  

General protein information

Preferred Names
proto-oncogene serine/threonine-protein kinase mos
Names
Moloney murine sarcoma viral (v-mos) oncogene homolog
Moloney sarcoma oncogene
c-mos
oocyte maturation factor mos
proto-oncogene c-Mos
v-mos moloney murine sarcoma viral oncogene homolog
NP_064487.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020102.4NP_064487.3  proto-oncogene serine/threonine-protein kinase mos

    See identical proteins and their annotated locations for NP_064487.3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P00539
    UniProtKB/TrEMBL
    A6JFL8, M0R4F9
    Related
    ENSRNOP00000064243.1, ENSRNOT00000011602.7
    Conserved Domains (2) summary
    smart00220
    Location:64331
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13979
    Location:58329
    STKc_Mos; Catalytic domain of the Serine/Threonine kinase, Oocyte maturation factor Mos

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    21657549..21658856 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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