Lipc lipase C, hepatic type [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lipcprovided by RGD
Official Full Name: lipase C, hepatic typeprovided by RGD
Primary source: RGD:3009
See related: Ensembl:ENSRNOG00000060338 AllianceGenome:RGD:3009
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including heparan sulfate proteoglycan binding activity; lipase activity; and lipoprotein particle binding activity. Involved in several processes, including glycerolipid metabolic process; low-density lipoprotein particle clearance; and plasma lipoprotein particle remodeling. Located in several cellular components, including cell surface; endosome; and microvillus. Used to study several diseases, including end stage renal disease; hepatitis; hyperinsulinism; obesity; and protein-energy malnutrition. Biomarker of ischemia. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; coronary artery disease; familial combined hyperlipidemia; peripheral vascular disease; and type 2 diabetes mellitus. Orthologous to human LIPC (lipase C, hepatic type). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 1092.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (80390470..80516463, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (71509633..71635663, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (77272582..77398485, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the binding of hepatic lipase with proteoglycans on the cell surface exerts a positive feedback on cellular proteoglycans production.
Title: Association of hepatic lipase with proteoglycans stimulates the production of proteoglycans in vivo and in vitro.
data suggest that hepatic lipase is a component of the LDL receptor-related protein-proteoglycan clusters, and that HL helps to direct cholesterol to the tissues in which it is localized by a nonenzymatic mechanism
Title: Removal of chylomicron remnants in transgenic mice overexpressing normal and membrane-anchored hepatic lipase.
rat plasma contains a larger form of hepatic lipase that is inactive in in vitro assay
Title: Inactive hepatic lipase in rat plasma.

Submit: New GeneRIF Correction

General gene information

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Markers

RH94586 (e-PCR)
- UniSTS:119834

AU025888 (e-PCR)
- UniSTS:114821

G47926 (e-PCR)
- UniSTS:108692

RH94786 (e-PCR)
- UniSTS:120033

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-acyl-2-lysophosphatidylserine acylhydrolase activity	IEA Inferred from Electronic Annotation more info
enables acetylesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables acylglycerol lipase activity	IDA Inferred from Direct Assay more info	PubMed
enables acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables apolipoprotein binding	IBA Inferred from Biological aspect of Ancestor more info
enables apolipoprotein binding	IDA Inferred from Direct Assay more info	PubMed
enables apolipoprotein binding	IPI Inferred from Physical Interaction more info	PubMed
enables chylomicron binding	IDA Inferred from Direct Assay more info	PubMed
enables heparan sulfate proteoglycan binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables lipase activity	ISO Inferred from Sequence Orthology more info
enables lipid binding	IDA Inferred from Direct Assay more info	PubMed
enables lipoprotein lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables low-density lipoprotein particle binding	IDA Inferred from Direct Assay more info	PubMed
enables lysophospholipase activity	IDA Inferred from Direct Assay more info	PubMed
enables lysophospholipase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidyl phospholipase B activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylserine 1-acylhydrolase activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A1 activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A1 activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase A1 activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A1 activity	ISO Inferred from Sequence Orthology more info
enables triglyceride lipase activity	IDA Inferred from Direct Assay more info	PubMed
enables triglyceride lipase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in aflatoxin metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in chylomicron remnant clearance	IDA Inferred from Direct Assay more info	PubMed
involved_in chylomicron remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in developmental growth	IEP Inferred from Expression Pattern more info	PubMed
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycerophospholipid catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in heparan sulfate proteoglycan biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in high-density lipoprotein particle remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in high-density lipoprotein particle remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in high-density lipoprotein particle remodeling	IEA Inferred from Electronic Annotation more info
involved_in high-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in low-density lipoprotein particle clearance	IDA Inferred from Direct Assay more info	PubMed
involved_in low-density lipoprotein particle remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in low-density lipoprotein particle remodeling	IEA Inferred from Electronic Annotation more info
involved_in low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in neutral lipid catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylcholine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylethanolamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylserine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of plasma lipoprotein particle levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to acetate	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to amino acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to calcium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to carbohydrate	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to copper ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to inorganic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to magnesium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in triglyceride catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride catabolic process	IEA Inferred from Electronic Annotation more info
involved_in triglyceride catabolic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride homeostasis	IEA Inferred from Electronic Annotation more info
involved_in triglyceride homeostasis	ISO Inferred from Sequence Orthology more info
involved_in triglyceride metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in very-low-density lipoprotein particle remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in very-low-density lipoprotein particle remodeling	IEA Inferred from Electronic Annotation more info
involved_in very-low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of high-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: hepatic triacylglycerol lipase

Names: HL; hepatic lipase; lipase member C; lipase, hepatic; lysophospholipase; phospholipase A1

NP_036729.2

EC 3.1.1.3

EC 3.1.1.32

EC 3.1.1.5

XP_006243421.1

EC 3.1.1.3

EC 3.1.1.32

EC 3.1.1.5

XP_006243422.1

EC 3.1.1.3

EC 3.1.1.32

EC 3.1.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012597.2 → NP_036729.2 hepatic triacylglycerol lipase precursor

See identical proteins and their annotated locations for NP_036729.2

Status: PROVISIONAL

Source sequence(s)

BC088160

UniProtKB/Swiss-Prot

P07867

UniProtKB/TrEMBL

A0A0G2K8I7, Q5M895

Related

ENSRNOP00000074623.1, ENSRNOT00000082763.2

Conserved Domains (3) summary

cd00707
Location:47 → 346

Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

cd01758
Location:353 → 488

PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...

pfam00151
Location:18 → 350

Lipase; Lipase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

80390470..80516463 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006243359.5 → XP_006243421.1 hepatic triacylglycerol lipase isoform X1

UniProtKB/Swiss-Prot

P07867

UniProtKB/TrEMBL

A0A0G2K6S7

Related

ENSRNOP00000073927.1

Conserved Domains (3) summary

cd00707
Location:47 → 362

Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

cd01758
Location:369 → 504

PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...

pfam00151
Location:18 → 366

Lipase; Lipase
XM_006243360.4 → XP_006243422.1 hepatic triacylglycerol lipase isoform X2

See identical proteins and their annotated locations for XP_006243422.1

UniProtKB/Swiss-Prot

P07867

UniProtKB/TrEMBL

A0A0G2K8I7, Q5M895

Conserved Domains (3) summary

cd00707
Location:47 → 346

Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

cd01758
Location:353 → 488

PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...

pfam00151
Location:18 → 350

Lipase; Lipase