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Ldha lactate dehydrogenase A [ Rattus norvegicus (Norway rat) ]

Gene ID: 24533, updated on 4-Jan-2025

Summary

Symbol
Ldhaprovided by RGD
Full Name
lactate dehydrogenase Aprovided by RGD
Primary source
RGD:2996
See related
EnsemblRapid:ENSRNOG00000013009 AllianceGenome:RGD:2996
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CDK1; Ldh1
Summary
Enables several functions, including L-lactate dehydrogenase activity; NAD binding activity; and identical protein binding activity. Involved in several processes, including response to cAMP; response to estrogen; and response to hydrogen peroxide. Predicted to be located in sperm fibrous sheath. Predicted to be part of oxidoreductase complex. Predicted to be active in cytosol and mitochondrion. Biomarker of hyperglycemia and hypertension. Orthologous to human LDHA (lactate dehydrogenase A). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Muscle (RPKM 10393.8), Liver (RPKM 4796.8) and 8 other tissues See more
Orthologs
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Genomic context

See Ldha in Genome Data Viewer
Location:
1q22
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (106508092..106517512)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (97371823..97381247)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (102900288..102909713)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene HPS5, biogenesis of lysosomal organelles complex 2 subunit 2 Neighboring gene uncharacterized LOC134483108 Neighboring gene general transcription factor IIH subunit 1 Neighboring gene uncharacterized LOC102552634 Neighboring gene uncharacterized LOC120099812 Neighboring gene lactate dehydrogenase C Neighboring gene tumor susceptibility 101

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-lactate dehydrogenase activity  
enables L-lactate dehydrogenase activity PubMed 
enables L-lactate dehydrogenase activity  
enables L-lactate dehydrogenase activity  
enables NAD binding PubMed 
enables identical protein binding PubMed 
enables identical protein binding  
enables kinase binding PubMed 
enables lactate dehydrogenase activity PubMed 
enables lactate dehydrogenase activity  
enables protein binding PubMed 
Process Evidence Code Pubs
involved_in NAD metabolic process PubMed 
acts_upstream_of_or_within glucose catabolic process to lactate via pyruvate  
involved_in lactate metabolic process  
involved_in lactate metabolic process PubMed 
involved_in lactate metabolic process  
involved_in lactate metabolic process  
involved_in liver development PubMed 
involved_in positive regulation of apoptotic process PubMed 
involved_in pyruvate catabolic process  
involved_in pyruvate metabolic process  
involved_in pyruvate metabolic process  
involved_in response to cAMP PubMed 
involved_in response to estrogen PubMed 
involved_in response to glucose PubMed 
involved_in response to hydrogen peroxide PubMed 
involved_in response to hypoxia PubMed 
involved_in response to nutrient PubMed 
involved_in response to organic cyclic compound PubMed 
involved_in response to xenobiotic stimulus PubMed 
involved_in skeletal muscle tissue development PubMed 
involved_in substantia nigra development PubMed 
Component Evidence Code Pubs
located_in cytoplasm  
is_active_in cytosol  
located_in cytosol  
is_active_in mitochondrion  
part_of oxidoreductase complex  
located_in sperm fibrous sheath  

General protein information

Preferred Names
L-lactate dehydrogenase A chain
Names
LDH muscle subunit
LDH-A
LDH-M
NP_058721.1
XP_006229294.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017025.2NP_058721.1  L-lactate dehydrogenase A chain

    See identical proteins and their annotated locations for NP_058721.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P04642
    UniProtKB/TrEMBL
    A0A8I6AMT0, B5DEN4
    Related
    ENSRNOP00000083496.2, ENSRNOT00000102543.2
    Conserved Domains (1) summary
    cd05293
    Location:19329
    LDH_1; A subgroup of L-lactate dehydrogenases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    106508092..106517512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229232.5XP_006229294.1  L-lactate dehydrogenase A chain isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZX39, A0A8I6AMT0
    Related
    ENSRNOP00000017468.2, ENSRNOT00000017468.4
    Conserved Domains (2) summary
    cd05293
    Location:48358
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:54353
    L-LDH-NAD; L-lactate dehydrogenase
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