Ldha lactate dehydrogenase A [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ldhaprovided by RGD
Full Name: lactate dehydrogenase Aprovided by RGD
Primary source: RGD:2996
See related: Ensembl:ENSRNOG00000013009 AllianceGenome:RGD:2996
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CDK1; Ldh1
Summary: Enables several functions, including L-lactate dehydrogenase activity; NAD binding activity; and identical protein binding activity. Involved in several processes, including response to cAMP; response to estrogen; and response to glucose. Predicted to be located in cytosol and sperm fibrous sheath. Biomarker of hyperglycemia. Orthologous to human LDHA (lactate dehydrogenase A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 10393.8), Liver (RPKM 4796.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (106508092..106517512)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (97371823..97381247)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (102900288..102909713)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arginine is neuroprotective through suppressing HIF-1alpha/LDHA-mediated inflammatory response after cerebral ischemia/reperfusion injury.
Title: Arginine is neuroprotective through suppressing HIF-1α/LDHA-mediated inflammatory response after cerebral ischemia/reperfusion injury.
LDH-A may be considered as a potential target for alleviating or treating Diabetes-associated Cognitive DeclineDiabetes-associated Cognitive Decline in the future.
Title: Metabolomic Analysis Identifies Lactate as an Important Pathogenic Factor in Diabetes-associated Cognitive Decline Rats.
LDHA is a direct target of miR-34a, which binds to the 3'-UTR region of LDHA mRNA in cardiomyocytes.
Title: Attenuation of miR-34a protects cardiomyocytes against hypoxic stress through maintenance of glycolysis.
role of lactate dehydrogenase-A (LDHA), which is a key enzyme for glycolysis, in the proliferation and migration of vascular smooth muscle cells
Title: Lactate dehydrogenase-A is indispensable for vascular smooth muscle cell proliferation and migration.
After 30 min of ischemia, the kidney maintains LDH metabolic function in spite of decreased kidney function, whereas the postischemic kidney after 60 min of ischemia show a generally reduced LDH enzyme activity concomitant with a reduced kidney function.
Title: In situ lactate dehydrogenase activity: a novel renal cortical imaging biomarker of tubular injury?
The expression of three well-defined downstream targets of hypoxia inducible factor 1 alpha subunit (HIF-1alpha), pyruvate dehydrogenase kinase 1 (PDK1), lactate dehydrogenase A (LDHA) and vascular endothelial growth factor (VEGF), were up-regulated in hippocampus after 28 days of simulated microgravity exposure.
Title: Activation of HIF-1α and its downstream targets in rat hippocampus after long-term simulated microgravity exposure.
aging alters aspects of skeletal muscle isoform shift induced by overload and anabolic steroid administration
Title: Lactate dehydrogenase regulation in aged skeletal muscle: Regulation by anabolic steroids and functional overload.
Lactate dehydrogenase a expression is necessary to sustain rapid angiogenesis of pulmonary microvascular endothelium.
Title: Lactate dehydrogenase a expression is necessary to sustain rapid angiogenesis of pulmonary microvascular endothelium.
M-LDH released from cardiomyocytes after hypoxia and reoxygenation has a role in protecting the heart from oxidative stress-induced injury through an intracellular signal transduction pathway involving ERK1/2.
Title: Identification and physiological activity of survival factor released from cardiomyocytes during ischaemia and reperfusion.
lactate dehydrogenase subunit A mRNA stability is regulated by Cyclic AMP and AKAP-mediated targeting of protein kinase A
Title: Cyclic AMP and AKAP-mediated targeting of protein kinase A regulates lactate dehydrogenase subunit A mRNA stability.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ldha (e-PCR), detects polymorphism
- UniSTS:507016

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-lactate dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-lactate dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables L-lactate dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables L-lactate dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables NAD binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables lactate dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables lactate dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in NAD metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to extracellular stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose catabolic process to lactate via pyruvate	ISO Inferred from Sequence Orthology more info
involved_in lactate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lactate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lactate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lactate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in liver development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in pyruvate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in pyruvate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyruvate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in skeletal muscle tissue development	IDA Inferred from Direct Assay more info	PubMed
involved_in substantia nigra development	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
part_of oxidoreductase complex	ISO Inferred from Sequence Orthology more info
located_in sperm fibrous sheath	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: L-lactate dehydrogenase A chain

Names: LDH muscle subunit; LDH-A; LDH-M

NP_058721.1

EC 1.1.1.27

XP_006229294.1

EC 1.1.1.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017025.2 → NP_058721.1 L-lactate dehydrogenase A chain

See identical proteins and their annotated locations for NP_058721.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P04642

UniProtKB/TrEMBL

A0A8I6AMT0, B5DEN4

Related

ENSRNOP00000017468.1, ENSRNOT00000017468.3

Conserved Domains (1) summary

cd05293
Location:19 → 329

LDH_1; A subgroup of L-lactate dehydrogenases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

106508092..106517512

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006229232.5 → XP_006229294.1 L-lactate dehydrogenase A chain isoform X1

UniProtKB/TrEMBL

A0A8I5ZX39, A0A8I6AMT0

Related

ENSRNOP00000083496.1

Conserved Domains (2) summary

cd05293
Location:48 → 358

LDH_1; A subgroup of L-lactate dehydrogenases

TIGR01771
Location:54 → 353

L-LDH-NAD; L-lactate dehydrogenase