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Lcat lecithin cholesterol acyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 24530, updated on 5-Mar-2024

Summary

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Official Symbol
Lcatprovided by RGD
Official Full Name
lecithin cholesterol acyltransferaseprovided by RGD
Primary source
RGD:2993
See related
Ensembl:ENSRNOG00000019573 AllianceGenome:RGD:2993
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables phosphatidylcholine-sterol O-acyltransferase activity and phospholipase A2 activity. Involved in several processes, including cholesterol metabolic process; response to copper ion; and response to glucocorticoid. Predicted to be part of high-density lipoprotein particle. Predicted to be active in extracellular space. Used to study end stage renal disease; familial hyperlipidemia; and myocardial infarction. Human ortholog(s) of this gene implicated in Norum disease and arteriosclerosis. Orthologous to human LCAT (lecithin-cholesterol acyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 1462.7) and Brain (RPKM 58.9) See more
Orthologs
human mouse all
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Genomic context

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Location:
19q12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50744598..50748064, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33834748..33838214, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37913333..37916799, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene chymotrypsin-like Neighboring gene proteasome 20S subunit beta 10 Neighboring gene solute carrier family 12 member 4 Neighboring gene uncharacterized LOC120098640 Neighboring gene dipeptidase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Preventive effect of S-allyl cysteine sulfoxide (alliin) on cardiac marker enzymes and lipids in isoproterenol-induced myocardial injury. Sangeetha T, et al. J Pharm Pharmacol, 2006 May. PMID 16640830
  2. Negative charge at amino acid 149 is the molecular determinant for substrate specificity of lecithin: cholesterol acyltransferase for phosphatidylcholine containing 20-carbon sn-2 fatty acyl chains. Zhao Y, et al. Biochemistry, 2003 Dec 2. PMID 14636062
  3. Cloning and in vitro expression of rat lecithin:cholesterol acyltransferase. Wang J, et al. Biochim Biophys Acta, 1997 Jun 23. PMID 9219904
  4. Plasma lecithin: cholesterol acyltransferase in copper-deficient rats. Lau BW, et al. J Nutr, 1981 Oct. PMID 7288494
  5. Isolation and specificity of rat lecithin: cholesterol acyltransferase: comparison with the human enzyme using reassembled high-density lipoproteins containing ether analogs of phosphatidylcholine. Pownall HJ, et al. Biochim Biophys Acta, 1985 Mar 6. PMID 3918579

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC108718

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IEA
Inferred from Electronic Annotation
more info
  
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity ISO
Inferred from Sequence Orthology
more info
  
enables apolipoprotein A-I binding IEA
Inferred from Electronic Annotation
more info
  
enables apolipoprotein A-I binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylcholine-sterol O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylcholine-sterol O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylcholine-sterol O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylcholine-sterol O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables phospholipase A2 activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables platelet-activating factor acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables platelet-activating factor acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables sterol esterase activity IEA
Inferred from Electronic Annotation
more info
  
enables sterol esterase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in aflatoxin metabolic process IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cholesterol homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cholesterol transport ISO
Inferred from Sequence Orthology
more info
  
involved_in high-density lipoprotein particle remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in high-density lipoprotein particle remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipoprotein biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipoprotein biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipoprotein metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylcholine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylcholine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylcholine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylcholine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phospholipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of high-density lipoprotein particle assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of high-density lipoprotein particle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in response to copper ion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to glucocorticoid IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in reverse cholesterol transport IEA
Inferred from Electronic Annotation
more info
  
involved_in reverse cholesterol transport ISO
Inferred from Sequence Orthology
more info
  
involved_in very-low-density lipoprotein particle remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in very-low-density lipoprotein particle remodeling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of high-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
  
part_of high-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphatidylcholine-sterol acyltransferase
Names
1-alkyl-2-acetylglycerophosphocholine esterase
Lecithin-cholesterol acyltransferase
PAF acetylhydrolase
phospholipid-cholesterol acyltransferase
platelet-activating factor acetylhydrolase
NP_058720.2
XP_006255503.1
XP_038953400.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017024.2 → NP_058720.2  phosphatidylcholine-sterol acyltransferase precursor

    See identical proteins and their annotated locations for NP_058720.2

    Status: PROVISIONAL

    Source sequence(s)
    BC091155
    UniProtKB/Swiss-Prot
    O35849, P18424
    UniProtKB/TrEMBL
    A0A8L2QED8, A6IYU6
    Related
    ENSRNOP00000026583.4, ENSRNOT00000026585.6
    Conserved Domains (1) summary
    cl21494
    Location:83 → 408
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    50744598..50748064 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097472.2 → XP_038953400.1  phosphatidylcholine-sterol acyltransferase isoform X1

    UniProtKB/TrEMBL
    A6IYU9
    Conserved Domains (1) summary
    cl21494
    Location:59 → 384
    Abhydrolase; alpha/beta hydrolases

  2. XM_006255441.3 → XP_006255503.1  phosphatidylcholine-sterol acyltransferase isoform X2

    UniProtKB/TrEMBL
    A6IYU9
    Conserved Domains (2) summary
    COG0596
    Location:125 → 301
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    cl21494
    Location:44 → 369
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18424.2 GenPept UniProtKB/Swiss-Prot:P18424

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