U.S. flag

An official website of the United States government

Il1a interleukin 1 alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 24493, updated on 4-Jan-2025

Summary

Official Symbol
Il1aprovided by RGD
Official Full Name
interleukin 1 alphaprovided by RGD
Primary source
RGD:2890
See related
EnsemblRapid:ENSRNOG00000004575 AllianceGenome:RGD:2890
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
IL-1F1; IL-1 alpha
Summary
Predicted to enable copper ion binding activity and cytokine activity. Involved in several processes, including keratinization; negative regulation of establishment of Sertoli cell barrier; and positive regulation of intracellular signal transduction. Located in cell surface and extracellular space. Used to study interstitial lung disease. Biomarker of several diseases, including endometritis; lung disease (multiple); urinary tract infection; uveitis; and varicocele. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Schnitzler syndrome; autoimmune disease (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human IL1A (interleukin 1 alpha). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 64.8), Lung (RPKM 41.1) and 6 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Il1a in Genome Data Viewer
Location:
3q36
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (136979804..136990236, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (116526601..116537055, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (121824712..121836122, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549265 Neighboring gene cytoskeleton associated protein 2-like Neighboring gene uncharacterized LOC120101660 Neighboring gene interleukin 1 beta Neighboring gene signal-regulatory protein beta 3 Neighboring gene uncharacterized LOC134486440 Neighboring gene uncharacterized LOC134486442

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables copper ion binding  
enables copper ion binding  
enables copper ion binding  
enables cytokine activity  
enables cytokine activity  
enables cytokine activity  
enables interleukin-1 receptor binding  
Items 1 - 25 of 67
Process Evidence Code Pubs
involved_in cellular response to heat  
involved_in cellular response to heat  
involved_in cellular response to heat  
involved_in cellular response to lipopolysaccharide  
involved_in connective tissue replacement involved in inflammatory response wound healing  
acts_upstream_of_or_within connective tissue replacement involved in inflammatory response wound healing  
involved_in cytokine production  
involved_in cytokine-mediated signaling pathway  
involved_in cytokine-mediated signaling pathway  
involved_in cytokine-mediated signaling pathway  
involved_in ectopic germ cell programmed cell death  
acts_upstream_of_or_within ectopic germ cell programmed cell death  
involved_in extrinsic apoptotic signaling pathway in absence of ligand  
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand  
involved_in fever generation  
involved_in heart development PubMed 
involved_in immune response  
involved_in immune response  
involved_in inflammatory response  
involved_in intracellular sodium ion homeostasis  
acts_upstream_of_or_within intracellular sodium ion homeostasis  
involved_in keratinization PubMed 
involved_in negative regulation of cell population proliferation  
involved_in negative regulation of cell population proliferation  
involved_in negative regulation of establishment of Sertoli cell barrier PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
involved_in positive regulation of JNK cascade PubMed 
involved_in positive regulation of angiogenesis  
involved_in positive regulation of angiogenesis  
involved_in positive regulation of canonical NF-kappaB signal transduction  
involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
involved_in positive regulation of cell division  
involved_in positive regulation of cytokine production  
involved_in positive regulation of cytokine production  
involved_in positive regulation of gene expression  
involved_in positive regulation of immature T cell proliferation in thymus  
involved_in positive regulation of interleukin-2 production  
acts_upstream_of positive regulation of interleukin-2 production PubMed 
involved_in positive regulation of interleukin-2 production  
acts_upstream_of positive regulation of interleukin-6 production PubMed 
involved_in positive regulation of interleukin-6 production PubMed 
involved_in positive regulation of mitotic nuclear division  
involved_in positive regulation of mitotic nuclear division  
involved_in positive regulation of neutrophil migration PubMed 
involved_in positive regulation of prostaglandin secretion PubMed 
involved_in positive regulation of protein secretion  
involved_in positive regulation of protein secretion  
involved_in positive regulation of steroid biosynthetic process PubMed 
involved_in positive regulation of stress-activated MAPK cascade PubMed 
involved_in positive regulation of transcription by RNA polymerase II  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
acts_upstream_of positive regulation of tumor necrosis factor production PubMed 
involved_in positive regulation of vascular endothelial growth factor production  
involved_in positive regulation of vascular endothelial growth factor production  
involved_in regulation of ERK1 and ERK2 cascade  
involved_in regulation of actin cytoskeleton organization PubMed 
involved_in response to L-ascorbic acid PubMed 
involved_in response to copper ion  
involved_in response to copper ion  
involved_in response to copper ion  
involved_in response to gamma radiation PubMed 
involved_in response to hypoxia PubMed 
involved_in response to lipopolysaccharide PubMed 
involved_in response to organic cyclic compound PubMed 
involved_in response to ozone PubMed 
involved_in signal transduction  
involved_in spermatogenesis PubMed 
Items 1 - 25 of 67
Component Evidence Code Pubs
located_in cell surface PubMed 
located_in cytosol  
located_in cytosol  
located_in cytosol  
is_active_in extracellular space  
located_in extracellular space PubMed 
located_in extracellular space  
located_in extracellular space  
located_in extracellular space  
located_in nucleus  

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017019.2NP_058715.1  interleukin-1 alpha

    See identical proteins and their annotated locations for NP_058715.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    P16598, Q546R9
    UniProtKB/TrEMBL
    F1LQB1
    Related
    ENSRNOP00000006113.7, ENSRNOT00000006113.10
    Conserved Domains (2) summary
    smart00125
    Location:131270
    IL1; Interleukin-1 homologues
    pfam02394
    Location:1109
    IL1_propep; Interleukin-1 propeptide

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    136979804..136990236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104245.2XP_038960173.1  interleukin-1 alpha isoform X2

    UniProtKB/TrEMBL
    F1MAF9, Q9ESW2
    Related
    ENSRNOP00000006126.7, ENSRNOT00000006126.9
    Conserved Domains (2) summary
    pfam02394
    Location:1107
    IL1_propep; Interleukin-1 propeptide
    cl00094
    Location:106212
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
  2. XM_039104244.2XP_038960172.1  interleukin-1 alpha isoform X1

    UniProtKB/Swiss-Prot
    P16598, Q546R9
    UniProtKB/TrEMBL
    F1LQB1
    Conserved Domains (2) summary
    smart00125
    Location:131270
    IL1; Interleukin-1 homologues
    pfam02394
    Location:1109
    IL1_propep; Interleukin-1 propeptide
External link. Please review our privacy policy.