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Mtnr1b melatonin receptor 1B [ Mus musculus (house mouse) ]

Gene ID: 244701, updated on 11-Apr-2024

Summary

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Official Symbol
Mtnr1bprovided by MGI
Official Full Name
melatonin receptor 1Bprovided by MGI
Primary source
MGI:MGI:2181726
See related
Ensembl:ENSMUSG00000050901 AllianceGenome:MGI:2181726
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mt2; Mel1b; Mel-1B-R
Summary
Predicted to enable melatonin receptor activity. Predicted to be involved in several processes, including negative regulation of cGMP-mediated signaling; negative regulation of transport; and regulation of transmission of nerve impulse. Predicted to act upstream of or within circadian rhythm. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in central nervous system; eye; gut; and reproductive system. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MTNR1B (melatonin receptor 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
9 A2; 9 5.15 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (15773910..15785852, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (15862614..15874556, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene high mobility group box 2 pseudogene Neighboring gene solute carrier family 36 (proton/amino acid symporter), member 4 Neighboring gene STARR-seq mESC enhancer starr_23387 Neighboring gene STARR-seq mESC enhancer starr_23388 Neighboring gene STARR-seq mESC enhancer starr_23389 Neighboring gene FAT atypical cadherin 3 Neighboring gene STARR-seq mESC enhancer starr_23390 Neighboring gene STARR-seq mESC enhancer starr_23391 Neighboring gene STARR-seq mESC enhancer starr_23392 Neighboring gene STARR-seq mESC enhancer starr_23393 Neighboring gene predicted gene, 53499 Neighboring gene STARR-seq mESC enhancer starr_23398 Neighboring gene STARR-seq mESC enhancer starr_23400 Neighboring gene STARR-seq mESC enhancer starr_23401 Neighboring gene nucleophosmin 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Melatonin Type 2 Receptor Activation Regulates Blue Light Exposure-Induced Mouse Corneal Epithelial Damage by Modulating Impaired Autophagy and Apoptosis. Jin R, et al. Int J Mol Sci, 2022 Sep 26. PMID 36232639, Free PMC Article
  2. Mice lacking melatonin MT2 receptors exhibit attentional deficits, anxiety and enhanced social interaction. Thomson DM, et al. J Psychopharmacol, 2021 Oct. PMID 34304635, Free PMC Article
  3. Dysfunction of serotonergic activity and emotional responses across the light-dark cycle in mice lacking melatonin  MT(2) receptors. Comai S, et al. J Pineal Res, 2020 Aug. PMID 32239546
  4. Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes. Tuomi T, et al. Cell Metab, 2016 Jun 14. PMID 27185156
  5. Melatonin inhibits granulocyte adhesion to ICAM via MT3/QR2 and MT2 receptors. Černyšiov V, et al. Int Immunol, 2015 Dec. PMID 26031343

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Melatonin Alleviates Lipopolysaccharide-Induced Abnormal Pregnancy through MTNR1B Regulation of m6A.
    Title: Melatonin Alleviates Lipopolysaccharide-Induced Abnormal Pregnancy through MTNR1B Regulation of m6A.
  2. Astrocyte-Ablation of Mtnr1b Increases Anxiety-Like Behavior in Adult Male Mice.
    Title: Astrocyte-Ablation of Mtnr1b Increases Anxiety-Like Behavior in Adult Male Mice.
  3. The Uterine Melatonergic Systems of AANAT and Melatonin Membrane Receptor 2 (MT2) Are Essential for Endometrial Receptivity and Early Implantation in Mice.
    Title: The Uterine Melatonergic Systems of AANAT and Melatonin Membrane Receptor 2 (MT2) Are Essential for Endometrial Receptivity and Early Implantation in Mice.
  4. Melatonin Type 2 Receptor Activation Regulates Blue Light Exposure-Induced Mouse Corneal Epithelial Damage by Modulating Impaired Autophagy and Apoptosis.
    Title: Melatonin Type 2 Receptor Activation Regulates Blue Light Exposure-Induced Mouse Corneal Epithelial Damage by Modulating Impaired Autophagy and Apoptosis.
  5. Mice lacking melatonin MT2 receptors exhibit attentional deficits, anxiety and enhanced social interaction.
    Title: Mice lacking melatonin MT2 receptors exhibit attentional deficits, anxiety and enhanced social interaction.
  6. Dysfunction of serotonergic activity and emotional responses across the light-dark cycle in mice lacking melatonin MT2 receptors.
    Title: Dysfunction of serotonergic activity and emotional responses across the light-dark cycle in mice lacking melatonin  MT(2) receptors.
  7. Melatonin recovers sleep phase delayed by MK-801 through the melatonin MT2 receptor- Ca(2+) -CaMKII-CREB pathway in the ventrolateral preoptic nucleus.
    Title: Melatonin recovers sleep phase delayed by MK-801 through the melatonin MT(2) receptor- Ca(2+) -CaMKII-CREB pathway in the ventrolateral preoptic nucleus.
  8. Nociceptive responses in melatonin MT2 receptor knockout mice compared to MT1 and double MT1 /MT2 receptor knockout mice.
    Title: Nociceptive responses in melatonin MT(2) receptor knockout mice compared to MT(1) and double MT(1) /MT(2) receptor knockout mice.
  9. Changes in melatonin receptor expression in a murine model of glaucoma.
    Title: Changes in melatonin receptor expression in a murine model of glaucoma.
  10. Pharmacological evidence for transactivation within melatonin MT2 and serotonin 5-HT2C receptor heteromers in mouse brain.
    Title: Pharmacological evidence for transactivation within melatonin MT(2) and serotonin 5-HT(2C) receptor heteromers in mouse brain.
Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC129286, MGC129287

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables melatonin receptor activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISA
Inferred from Sequence Alignment
more info
 PubMed 
acts_upstream_of_or_within circadian rhythm TAS
Traceable Author Statement
more info
 PubMed 
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cGMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transmission of nerve impulse ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transmission of nerve impulse ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuronal action potential ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISA
Inferred from Sequence Alignment
more info
 PubMed 

General protein information

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Preferred Names
melatonin receptor type 1B
Names
MT2 melatonin receptor
Mel-1b melatonin receptor
mel1b receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145712.2 → NP_663758.2  melatonin receptor type 1B

    See identical proteins and their annotated locations for NP_663758.2

    Status: VALIDATED

    Source sequence(s)
    AB377276
    Consensus CDS
    CCDS22841.1
    UniProtKB/Swiss-Prot
    Q80T38, Q8CIQ6, Q8K3K0
    UniProtKB/TrEMBL
    Q3SXF8
    Related
    ENSMUSP00000053086.6, ENSMUST00000057920.7
    Conserved Domains (2) summary
    pfam00001
    Location:57 → 308
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:55 → 192
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    15773910..15785852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CIQ6.1 GenPept UniProtKB/Swiss-Prot:Q8CIQ6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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