Grm1 glutamate metabotropic receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Grm1provided by RGD
Official Full Name: glutamate metabotropic receptor 1provided by RGD
Primary source: RGD:2742
See related: Ensembl:ENSRNOG00000014290 AllianceGenome:RGD:2742
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gprc1a
Summary: Enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential and estrogen receptor binding activity. Involved in several processes, including G protein-coupled glutamate receptor signaling pathway; calcium-mediated signaling; and regulation of glutamatergic synaptic transmission. Located in axon; dendritic spine; and synaptic membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 13 and spinocerebellar ataxia 44. Orthologous to human GRM1 (glutamate metabotropic receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 90.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 1p13

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (6878542..7273447, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (5058285..5453170, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (4753141..5165859, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mGluR1/IP3/ERK signaling pathway regulates vestibular compensation in ON UBCs of the cerebellar flocculus.
Title: mGluR1/IP3/ERK signaling pathway regulates vestibular compensation in ON UBCs of the cerebellar flocculus.
Activation of adenosine A1 receptor potentiates metabotropic glutamate receptor 1-mediated Ca[2+] mobilization in the rat hippocampal marginal zone.
Title: Activation of adenosine A(1) receptor potentiates metabotropic glutamate receptor 1-mediated Ca(2+) mobilization in the rat hippocampal marginal zone.
[Activation of metabotropic glutamate receptor 1 inhibits chronic intermittent hypoxia-induced carotid body plasticity in rats].
Title: [Activation of metabotropic glutamate receptor 1 inhibits chronic intermittent hypoxia-induced carotid body plasticity in rats].
Amygdala Metabotropic Glutamate Receptor 1 Influences Synaptic Transmission to Participate in Fentanyl-Induced Hyperalgesia in Rats.
Title: Amygdala Metabotropic Glutamate Receptor 1 Influences Synaptic Transmission to Participate in Fentanyl-Induced Hyperalgesia in Rats.
Stabilization of Spine Synaptopodin by mGluR1 Is Required for mGluR-LTD.
Title: Stabilization of Spine Synaptopodin by mGluR1 Is Required for mGluR-LTD.
Upregulation of Striatal Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Rats with Excessive Glutamate Release Induced by N-Acetylcysteine.
Title: Upregulation of Striatal Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Rats with Excessive Glutamate Release Induced by N-Acetylcysteine.
Group I metabotropic glutamate receptor-mediated long term depression is disrupted in the hippocampus of WAG/Rij rats modelling absence epilepsy.
Title: Group I metabotropic glutamate receptor-mediated long term depression is disrupted in the hippocampus of WAG/Rij rats modelling absence epilepsy.
Reciprocal regulation of spontaneous synaptic vesicle fusion by Fragile X mental retardation protein and group I metabotropic glutamate receptors.
Title: Reciprocal regulation of spontaneous synaptic vesicle fusion by Fragile X mental retardation protein and group I metabotropic glutamate receptors.
Arc silence aggravates traumatic neuronal injury via mGluR1-mediated ER stress and necroptosis.
Title: Arc silence aggravates traumatic neuronal injury via mGluR1-mediated ER stress and necroptosis.
Neuroprotective effects of mGluR5 activation through the PI3K/Akt pathway and the molecular switch of AMPA receptors.
Title: Neuroprotective effects of mGluR5 activation through the PI3K/Akt pathway and the molecular switch of AMPA receptors.

Submit: New GeneRIF Correction See all GeneRIFs (140)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Arb40 (e-PCR)
- UniSTS:240137

GDB:4585461 (e-PCR)
- UniSTS:74520

Grm1 (e-PCR), detects polymorphism
- UniSTS:506953

GRM1 (e-PCR)
- UniSTS:240266

D1Got3 (e-PCR)
- UniSTS:112332

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
enables PLC activating G protein-coupled glutamate receptor activity	TAS Traceable Author Statement more info	PubMed
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables glutamate receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables glutamate receptor activity	TAS Traceable Author Statement more info	PubMed
enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled glutamate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled glutamate receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in L-glutamate import across plasma membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within L-glutamate import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to electrical stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to electrical stimulus	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	IEP Inferred from Expression Pattern more info	PubMed
involved_in locomotory behavior	IEA Inferred from Electronic Annotation more info
involved_in locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization	TAS Traceable Author Statement more info	PubMed
involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of glutamate secretion	TAS Traceable Author Statement more info	PubMed
involved_in regulation of postsynaptic cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of sensory perception of pain	IEA Inferred from Electronic Annotation more info
involved_in regulation of sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic transmission, glutamatergic	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory perception of pain	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, GABAergic	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of G protein-coupled receptor dimeric complex	ISO Inferred from Sequence Orthology more info
part_of G protein-coupled receptor homodimeric complex	IEA Inferred from Electronic Annotation more info
part_of G protein-coupled receptor homodimeric complex	ISO Inferred from Sequence Orthology more info
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: metabotropic glutamate receptor 1

Names: G protein coupled receptor family C group 1 member A; glutamate receptor, metabotropic 1; mGluR1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114330.2 → NP_001107802.1 metabotropic glutamate receptor 1 isoform beta precursor

Status: VALIDATED

Description

Transcript Variant: his variant (2) encodes the shorter isoform (beta). Isoform beta has a different subcellular distribution than isoform alpha and may be functionally distinct due to differential G-protein coupling of its novel C-terminal sequence.

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P23385

UniProtKB/TrEMBL

Q9WTJ1

Related

ENSRNOP00000047790.3, ENSRNOT00000044325.4

Conserved Domains (4) summary

cd06374
Location:36 → 510

PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor

pfam00003
Location:604 → 837

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:77 → 485

ANF_receptor; Receptor family ligand binding region

pfam07562
Location:521 → 570

NCD3G; Nine Cysteines Domain of family 3 GPCR
NM_017011.2 → NP_058707.2 metabotropic glutamate receptor 1 isoform alpha precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (alpha).

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P23385

UniProtKB/TrEMBL

A6JP39, G3V7U1

Related

ENSRNOP00000019319.1, ENSRNOT00000019319.4

Conserved Domains (4) summary

cd15449
Location:591 → 840

7tmC_mGluR1; metabotropic glutamate receptor 1 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06374
Location:36 → 510

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

pfam07562
Location:521 → 571

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:1150 → 1199

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

6878542..7273447 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017588777.3 → XP_017444266.1 metabotropic glutamate receptor 1 isoform X1

UniProtKB/Swiss-Prot

P23385

UniProtKB/TrEMBL

A6JP39, G3V7U1

Conserved Domains (4) summary

cd15449
Location:591 → 840

7tmC_mGluR1; metabotropic glutamate receptor 1 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06374
Location:36 → 510

PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor

pfam07562
Location:521 → 571

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam10606
Location:1150 → 1199

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
XM_063280712.1 → XP_063136782.1 metabotropic glutamate receptor 1 isoform X2