Grin1 glutamate ionotropic receptor NMDA type subunit 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Grin1provided by RGD
Official Full Name: glutamate ionotropic receptor NMDA type subunit 1provided by RGD
Primary source: RGD:2736
See related: Ensembl:ENSRNOG00000011726 AllianceGenome:RGD:2736
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: NR1; GluN1; NMDAR1
Summary: Enables several functions, including amino acid binding activity; amyloid-beta binding activity; and ligand-gated ion channel activity. Involved in several processes, including positive regulation of dendritic spine maintenance; protein heterotetramerization; and response to fungicide. Located in several cellular components, including dendrite; postsynaptic density; and synaptic cleft. Is integral component of plasma membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and parallel fiber to Purkinje cell synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic membrane. Biomarker of cognitive disorder; middle cerebral artery infarction; placental insufficiency; sciatic neuropathy; and status epilepticus. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant non-syndromic intellectual disability 8; and cerebral infarction. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 191.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 3p13

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (28501836..28528754, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (8103680..8130603, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (2507745..2534664, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reduced Expression of the Htr2a, Grin1, and Bdnf Genes and Cognitive Inflexibility in a Model of High Compulsive Rats.
Title: Reduced Expression of the Htr2a, Grin1, and Bdnf Genes and Cognitive Inflexibility in a Model of High Compulsive Rats.
Paternal stress alters synaptic density and expression of GAP-43, GRIN1, M1 and SYP genes in the hippocampus and cortex of offspring of stress-induced male rats.
Title: Paternal stress alters synaptic density and expression of GAP-43, GRIN1, M1 and SYP genes in the hippocampus and cortex of offspring of stress-induced male rats.
The pathogenic N650K variant in the GluN1 subunit regulates the trafficking, conductance, and pharmacological properties of NMDA receptors.
Title: The pathogenic N650K variant in the GluN1 subunit regulates the trafficking, conductance, and pharmacological properties of NMDA receptors.
The alpha2delta-1-NMDAR1 interaction in the trigeminal ganglion contributes to orofacial ectopic pain following inferior alveolar nerve injury.
Title: The α2δ-1-NMDAR1 interaction in the trigeminal ganglion contributes to orofacial ectopic pain following inferior alveolar nerve injury.
Involuntary, forced or voluntary exercise can ameliorate the cognitive deficits by enhancing levels of hippocampal NMDAR1, pAMPAR1 and pCaMKII in a model of vascular dementia.
Title: Involuntary, forced or voluntary exercise can ameliorate the cognitive deficits by enhancing levels of hippocampal NMDAR1, pAMPAR1 and pCaMKII in a model of vascular dementia.
The NMDA Receptor Subunit (GluN1 and GluN2A) Modulation Following Different Conditions of Cocaine Abstinence in Rat Brain Structures.
Title: The NMDA Receptor Subunit (GluN1 and GluN2A) Modulation Following Different Conditions of Cocaine Abstinence in Rat Brain Structures.
Upregulated expression of NMDA receptor in the paraventricular nucleus shortens ejaculation latency in rats with experimental autoimmune prostatitis.
Title: Upregulated expression of NMDA receptor in the paraventricular nucleus shortens ejaculation latency in rats with experimental autoimmune prostatitis.
Contribution of AMPA and NMDA receptors in the spontaneous firing patterns of single neurons in autaptic culture.
Title: Contribution of AMPA and NMDA receptors in the spontaneous firing patterns of single neurons in autaptic culture.
Disability-specific genes GRIN1, GRIN2 and CNR1 show injury-dependent protein expression in the lumbar spinal cord of CCI rats.
Title: Disability-specific genes GRIN1, GRIN2 and CNR1 show injury-dependent protein expression in the lumbar spinal cord of CCI rats.
Novel use of a chemically modified siRNA for robust and sustainable in vivo gene silencing in the retina.
Title: Novel use of a chemically modified siRNA for robust and sustainable in vivo gene silencing in the retina.

Submit: New GeneRIF Correction See all GeneRIFs (229)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Grin1 (e-PCR), detects polymorphism
- UniSTS:506952

Grin1 (e-PCR), detects polymorphism
- UniSTS:143260

PMC57740P2 (e-PCR)
- UniSTS:273365

UniSTS:465388 (e-PCR)
- UniSTS:465388

Grin1 (e-PCR), detects polymorphism
- UniSTS:465388

Grin1 (e-PCR), detects polymorphism
- UniSTS:531447

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NMDA glutamate receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables NMDA glutamate receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables NMDA glutamate receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to NMDA glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables NMDA glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables NMDA glutamate receptor activity	TAS Traceable Author Statement more info	PubMed
enables amyloid-beta binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to calcium channel activity	ISO Inferred from Sequence Orthology more info
enables calcium channel activity	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables glutamate binding	IDA Inferred from Direct Assay more info	PubMed
enables glutamate binding	ISO Inferred from Sequence Orthology more info
enables glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables glutamate-gated calcium ion channel activity	ISO Inferred from Sequence Orthology more info
enables glutamate-gated receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate-gated receptor activity	TAS Traceable Author Statement more info	PubMed
enables glycine binding	IDA Inferred from Direct Assay more info	PubMed
enables glycine binding	ISO Inferred from Sequence Orthology more info
enables ionotropic glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	EXP Inferred from Experiment more info	PubMed
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
enables monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables phosphatase binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables voltage-gated monoatomic cation channel activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within associative learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane import into cytosol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
NOT involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glycine	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to manganese ion	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cerebral cortex development	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within conditioned taste aversion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in ionotropic glutamate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ionotropic glutamate receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ionotropic glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ionotropic glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ionotropic glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ionotropic glutamate receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within learning or memory	ISO Inferred from Sequence Orthology more info
involved_in learning or memory	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within long-term memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within male mating behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within memory	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic cation transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within monoatomic cation transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron cellular homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within olfactory learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pons maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Schwann cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport into cytosol	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of dendritic spine maintenance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of excitatory postsynaptic potential	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of excitatory postsynaptic potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of reactive oxygen species biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of synaptic transmission, glutamatergic	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synaptic transmission, glutamatergic	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prepulse inhibition	ISO Inferred from Sequence Orthology more info
involved_in propylene metabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein heterotetramerization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein localization to postsynaptic membrane	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell communication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of monoatomic cation transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of monoatomic cation transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuronal synaptic plasticity	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of respiratory gaseous exchange	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in response to amine	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to amphetamine	ISO Inferred from Sequence Orthology more info
involved_in response to calcium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in response to fungicide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glycine	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to morphine	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in rhythmic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sensory perception of pain	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within social behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within startle response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within suckling behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of NMDA selective glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NMDA selective glutamate receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of NMDA selective glutamate receptor complex	IEA Inferred from Electronic Annotation more info
part_of NMDA selective glutamate receptor complex	ISO Inferred from Sequence Orthology more info
part_of NMDA selective glutamate receptor complex	ISS Inferred from Sequence or Structural Similarity more info
part_of NMDA selective glutamate receptor complex	TAS Traceable Author Statement more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite membrane	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic branch	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in excitatory synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in organelle	IEA Inferred from Electronic Annotation more info
is_active_in parallel fiber to Purkinje cell synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synaptic cleft	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic membrane	IPI Inferred from Physical Interaction more info	PubMed
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glutamate receptor ionotropic, NMDA 1

Names: N-methyl-D-aspartate glutamate receptor; N-methyl-D-aspartate receptor subunit NR1; NMD-R1; NMDA R1 receptor C1 cassette; glutamate [NMDA] receptor subunit zeta-1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; neurotransmitter receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270602.1 → NP_001257531.1 glutamate receptor ionotropic, NMDA 1 isoform 1b precursor

See identical proteins and their annotated locations for NP_001257531.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1b).

Source sequence(s)

FM039130, JAXUCZ010000003, U08263

UniProtKB/TrEMBL

A6JT40, Q62683

Related

ENSRNOP00000029227.5, ENSRNOT00000037725.6

Conserved Domains (3) summary

cd13719
Location:416 → 820

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06379
Location:25 → 404

PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

pfam10562
Location:856 → 884

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
NM_001270603.1 → NP_001257532.1 glutamate receptor ionotropic, NMDA 1 isoform 2b precursor

See identical proteins and their annotated locations for NP_001257532.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2b) has the same N- and C-termini but is shorter compared to isoform 1b.

Source sequence(s)

FM039130, JAXUCZ010000003, U08264

UniProtKB/TrEMBL

A6JT39, Q62683

Related

ENSRNOP00000043301.3, ENSRNOT00000044246.5

Conserved Domains (3) summary

cd13719
Location:416 → 820

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06379
Location:25 → 404

PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

pfam10562
Location:856 → 884

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
NM_001270605.1 → NP_001257534.1 glutamate receptor ionotropic, NMDA 1 isoform 2a precursor

See identical proteins and their annotated locations for NP_001257534.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (2a) has the same N- and C-termini but is shorter compared to isoform 1b.

Source sequence(s)

FM039130, JAXUCZ010000003, U08262

UniProtKB/TrEMBL

A6JT37, Q62683

Conserved Domains (3) summary

cd13719
Location:395 → 799

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06379
Location:25 → 383

PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

pfam10562
Location:835 → 863

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
NM_001270606.1 → NP_001257535.1 glutamate receptor ionotropic, NMDA 1 isoform 3b precursor

See identical proteins and their annotated locations for NP_001257535.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) uses an alternate splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (3b) has a shorter and distinct C-terminus compared to variant 1b.

Source sequence(s)

FM039130, JAXUCZ010000003, U08266

UniProtKB/TrEMBL

A0A0H2UHT2, A6JT36, Q62648, Q62683

Conserved Domains (3) summary

cd13719
Location:416 → 820

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06379
Location:25 → 404

PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

pfam10562
Location:856 → 884

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
NM_001270608.1 → NP_001257537.1 glutamate receptor ionotropic, NMDA 1 isoform 4b precursor

See identical proteins and their annotated locations for NP_001257537.1

Status: VALIDATED

Description

Transcript Variant: This variant (7) lacks an alternate in-frame exon and uses an alternate splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (4b) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1b.

Source sequence(s)

FM039130, JAXUCZ010000003, U08268

UniProtKB/TrEMBL

A6JT35, Q62683

Conserved Domains (3) summary

cd13719
Location:416 → 820

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06379
Location:25 → 404

PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

pfam10562
Location:856 → 884

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
NM_001270610.1 → NP_001257539.1 glutamate receptor ionotropic, NMDA 1 isoform 4a precursor

See identical proteins and their annotated locations for NP_001257539.1

Status: VALIDATED

Description

Transcript Variant: This variant (8) lacks two alternate in-frame exons and uses an alternate splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (4a) lacks two alternate internal segments and has a shorter and distinct C-terminus compared to isoform 1b.

Source sequence(s)

FM039130, JAXUCZ010000003, U08267

UniProtKB/TrEMBL

A6JT33, Q62683

Conserved Domains (3) summary

cd13719
Location:395 → 799

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06379
Location:25 → 383

PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

pfam10562
Location:835 → 863

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
NM_001287423.1 → NP_001274352.1 glutamate receptor ionotropic, NMDA 1 isoform 3a precursor

See identical proteins and their annotated locations for NP_001274352.1

Status: VALIDATED

Description

Transcript Variant: This variant (9) lacks an alternate in-frame exon and uses an alternate splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (3a) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1b.

Source sequence(s)

FM039130, JAXUCZ010000003, U08265

UniProtKB/TrEMBL

A6JT34, Q62683

Conserved Domains (3) summary

cd13719
Location:395 → 799

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06379
Location:25 → 383

PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

pfam10562
Location:835 → 863

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
NM_017010.2 → NP_058706.1 glutamate receptor ionotropic, NMDA 1 isoform 1a precursor

See identical proteins and their annotated locations for NP_058706.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (1a) has the same N- and C-termini but is shorter compared to isoform 1b.

Source sequence(s)

FM039130, JAXUCZ010000003, U08261

UniProtKB/Swiss-Prot

P35439, Q62646

UniProtKB/TrEMBL

A6JT38, Q62683

Related

ENSRNOP00000049198.1, ENSRNOT00000049297.4

Conserved Domains (3) summary

cd13719
Location:395 → 799

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06379
Location:25 → 383

PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

pfam10562
Location:835 → 863

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit