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Styk1 serine/threonine/tyrosine kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 243659, updated on 21-Apr-2024

Summary

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Official Symbol
Styk1provided by MGI
Official Full Name
serine/threonine/tyrosine kinase 1provided by MGI
Primary source
MGI:MGI:2141396
See related
Ensembl:ENSMUSG00000032899 AllianceGenome:MGI:2141396
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nok; 9130025L13
Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in cell differentiation; innate immune response; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within phosphorylation. Predicted to be located in plasma membrane. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in brain and olfactory epithelium. Orthologous to human STYK1 (serine/threonine/tyrosine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 8.7), colon adult (RPKM 6.8) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 F3; 6 63.44 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (131276096..131330532, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (131299133..131353836, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5582 Neighboring gene STARR-positive B cell enhancer ABC_E9280 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:131243245-131243354 Neighboring gene mago homolog B, exon junction complex core component Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:131303559-131303777 Neighboring gene STARR-seq mESC enhancer starr_17494 Neighboring gene Y box protein 3 Neighboring gene STARR-positive B cell enhancer mm9_chr6:131338351-131338652 Neighboring gene STARR-seq mESC enhancer starr_17495 Neighboring gene predicted gene, 22362 Neighboring gene STARR-seq mESC enhancer starr_17496 Neighboring gene ring finger and WD repeat domain 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Styk1 is specifically expressed in NK1.1(+) lymphocytes including NK, γδ T, and iNKT cells in mice, but is dispensable for their ontogeny and function. Wilharm A, et al. Eur J Immunol, 2019 May. PMID 30758858
  2. Styk1 expression is a hallmark of murine NK cells and other NK1.1(+) subsets but is dispensable for NK-cell development and effector functions. Fauteux-Daniel S, et al. Eur J Immunol, 2019 May. PMID 30690705, Free PMC Article
  3. Point mutation at single tyrosine residue of novel oncogene NOK abrogates tumorigenesis in nude mice. Chen Y, et al. Cancer Res, 2005 Dec 1. PMID 16322230
  4. Induction of chronic lymphocytic leukemia-like disease in STYK1/NOK transgenic mice. Yang Y, et al. Biochem Biophys Res Commun, 2022 Oct 20. PMID 35970044
  5. A novel protein tyrosine kinase NOK that shares homology with platelet- derived growth factor/fibroblast growth factor receptors induces tumorigenesis and metastasis in nude mice. Liu L, et al. Cancer Res, 2004 May 15. PMID 15150103

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Styk1 expression is specific for NK cells and selected NK-like innate T-cell subsets, but dispensable for their development and function.
    Title: Styk1 is specifically expressed in NK1.1(+) lymphocytes including NK, γδ T, and iNKT cells in mice, but is dispensable for their ontogeny and function.
  2. high Styk1 expression is a hallmark of NK cells and that Styk1 is not essential for NK cell development, activation and antiviral functions.
    Title: Styk1 expression is a hallmark of murine NK cells and other NK1.1(+) subsets but is dispensable for NK-cell development and effector functions.
  3. Point mutations at either Y327 or Y356 dramatically blocked cellular transformation by NOK as examined by colony formation and cellular DNA synthesis.
    Title: Point mutation at single tyrosine residue of novel oncogene NOK abrogates tumorigenesis in nude mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tyrosine-protein kinase STYK1
Names
NOK kinase
mNOK
novel oncogene with kinase domain
NP_001398609.1
NP_001398610.1
NP_001398611.1
NP_001398612.1
NP_001398613.1
NP_001398614.1
NP_766479.1
XP_006506194.1
XP_006506195.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411680.1 → NP_001398609.1  tyrosine-protein kinase STYK1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC122191, AC148326
    UniProtKB/Swiss-Prot
    Q6J9G1, Q8BZH6, Q8BZT1

  2. NM_001411681.1 → NP_001398610.1  tyrosine-protein kinase STYK1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC122191, AC148326
    UniProtKB/Swiss-Prot
    Q6J9G1, Q8BZH6, Q8BZT1

  3. NM_001411682.1 → NP_001398611.1  tyrosine-protein kinase STYK1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC122191, AC148326
    UniProtKB/Swiss-Prot
    Q6J9G1, Q8BZH6, Q8BZT1

  4. NM_001411683.1 → NP_001398612.1  tyrosine-protein kinase STYK1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC122191, AC148326

  5. NM_001411684.1 → NP_001398613.1  tyrosine-protein kinase STYK1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC122191, AC148326
    Related
    ENSMUSP00000112900.2, ENSMUST00000121078.2

  6. NM_001411685.1 → NP_001398614.1  tyrosine-protein kinase STYK1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC122191, AC148326

  7. NM_172891.3 → NP_766479.1  tyrosine-protein kinase STYK1 isoform a

    See identical proteins and their annotated locations for NP_766479.1

    Status: VALIDATED

    Source sequence(s)
    AC122191, AC148326
    Consensus CDS
    CCDS20604.1
    UniProtKB/Swiss-Prot
    Q6J9G1, Q8BZH6, Q8BZT1
    UniProtKB/TrEMBL
    B2RWV6
    Related
    ENSMUSP00000044098.2, ENSMUST00000049150.8
    Conserved Domains (1) summary
    cl21453
    Location:123 → 388
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    131276096..131330532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506131.4 → XP_006506194.1  tyrosine-protein kinase STYK1 isoform X1

    See identical proteins and their annotated locations for XP_006506194.1

    UniProtKB/Swiss-Prot
    Q6J9G1, Q8BZH6, Q8BZT1
    UniProtKB/TrEMBL
    B2RWV6
    Conserved Domains (1) summary
    cl21453
    Location:123 → 388
    PKc_like; Protein Kinases, catalytic domain

  2. XM_006506132.4 → XP_006506195.1  tyrosine-protein kinase STYK1 isoform X1

    See identical proteins and their annotated locations for XP_006506195.1

    UniProtKB/Swiss-Prot
    Q6J9G1, Q8BZH6, Q8BZT1
    UniProtKB/TrEMBL
    B2RWV6
    Conserved Domains (1) summary
    cl21453
    Location:123 → 388
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6J9G1.2 GenPept UniProtKB/Swiss-Prot:Q6J9G1

Gene LinkOut

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