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Eno2 enolase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24334, updated on 4-Jan-2025

Summary

Symbol
Eno2provided by RGD
Full Name
enolase 2provided by RGD
Primary source
RGD:2554
See related
EnsemblRapid:ENSRNOG00000013141 AllianceGenome:RGD:2554
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
NSE; RNEN3
Summary
Enables enzyme binding activity; identical protein binding activity; and phosphopyruvate hydratase activity. Involved in glucose metabolic process; response to estradiol; and response to xenobiotic stimulus. Located in several cellular components, including growth cone; membrane raft; and synaptic membrane. Part of phosphopyruvate hydratase complex. Biomarker of Parkinsonism and toxic shock syndrome. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human ENO2 (enolase 2). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information
Note: LOC100911625 appears to be a duplicate placement of Eno2 (GeneID: 24334) on Rnor_6.0 (Annot. Release 105) that is absent from Rn_Celera and is not supported by syntenic regions in mouse and human. BLAST analysis of the underlying component AABR07066868.1 against the rat genome shows high sequence identity (88% coverage, 99% identity) with part of NC_005103.4 on which Eno2 is annotated. Annotation of Eno2 at this location on Rnor_6.0 is supported by annotation on Rn_Celera and synteny with mouse and human. [14 Apr 2021]
Expression
Biased expression in Brain (RPKM 1706.0) and Uterus (RPKM 89.6) See more
Orthologs
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Genomic context

See Eno2 in Genome Data Viewer
Location:
4q42
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159258371..159267220, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157572085..157580971, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157285192..157294090, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene gene rich cluster, C10 gene Neighboring gene atrophin 1 Neighboring gene uncharacterized LOC120102384 Neighboring gene leucine rich repeat containing 23 Neighboring gene uncharacterized LOC134486638 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 2 Neighboring gene triosephosphate isomerase 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme binding PubMed 
enables identical protein binding PubMed 
enables magnesium ion binding  
enables phosphopyruvate hydratase activity  
enables phosphopyruvate hydratase activity PubMed 
enables phosphopyruvate hydratase activity  
enables phosphopyruvate hydratase activity PubMed 
enables protein-containing complex binding PubMed 
Process Evidence Code Pubs
involved_in canonical glycolysis PubMed 
involved_in gluconeogenesis PubMed 
involved_in glycolytic process  
involved_in glycolytic process  
involved_in response to estradiol PubMed 
involved_in response to organic cyclic compound PubMed 
involved_in response to xenobiotic stimulus PubMed 
Component Evidence Code Pubs
located_in cell cortex PubMed 
located_in cell surface PubMed 
located_in cytoplasm  
located_in cytosol  
located_in growth cone PubMed 
located_in membrane  
located_in membrane raft PubMed 
located_in neuronal cell body  
located_in perikaryon  
located_in perikaryon  
part_of phosphopyruvate hydratase complex  
part_of phosphopyruvate hydratase complex PubMed 
part_of phosphopyruvate hydratase complex  
located_in photoreceptor inner segment  
located_in photoreceptor inner segment  
located_in plasma membrane  
located_in plasma membrane  
located_in synaptic membrane PubMed 

General protein information

Preferred Names
gamma-enolase
Names
2-phospho-D-glycerate hydro-lyase
enolase 2, gamma, neuronal
gamma-enolase-like
neural enolase
neuron-specific enolase
NP_647541.1
XP_006237392.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139325.4NP_647541.1  gamma-enolase

    See identical proteins and their annotated locations for NP_647541.1

    Status: VALIDATED

    Source sequence(s)
    CB615520, JAXUCZ010000004
    UniProtKB/Swiss-Prot
    P07323
    UniProtKB/TrEMBL
    A0A8L2Q2X9, A6ILK1
    Related
    ENSRNOP00000005601.5, ENSRNOT00000005601.6
    Conserved Domains (1) summary
    PLN00191
    Location:2432
    PLN00191; enolase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    159258371..159267220 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237330.5XP_006237392.1  gamma-enolase isoform X1

    See identical proteins and their annotated locations for XP_006237392.1

    UniProtKB/Swiss-Prot
    P07323
    UniProtKB/TrEMBL
    A0A8L2Q2X9, A6ILK1
    Conserved Domains (1) summary
    PLN00191
    Location:2432
    PLN00191; enolase
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