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Sbno1 strawberry notch 1 [ Mus musculus (house mouse) ]

Gene ID: 243272, updated on 11-Apr-2024

Summary

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Official Symbol
Sbno1provided by MGI
Official Full Name
strawberry notch 1provided by MGI
Primary source
MGI:MGI:2384298
See related
Ensembl:ENSMUSG00000038095 AllianceGenome:MGI:2384298
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sno; Sbno; mSno1; 9330180L10Rik
Summary
Predicted to enable chromatin DNA binding activity and histone binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be active in nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; gut gland; and stomach. Orthologous to human SBNO1 (strawberry notch homolog 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 13.5), testis adult (RPKM 12.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 63.54 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124506765..124564059, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (124368702..124426007, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene mitochondrial translation release factor in rescue Neighboring gene cyclin dependent kinase 2 associated protein 1 Neighboring gene STARR-seq mESC enhancer starr_14338 Neighboring gene STARR-positive B cell enhancer ABC_E851 Neighboring gene lysine methyltransferase 5A Neighboring gene Rab interacting lysosomal protein-like 2 Neighboring gene peptidylprolyl isomerase A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Strawberry Notch 1 (SBNO1) promotes proliferation of spermatogonial stem cells via the noncanonical Wnt pathway in mice. Shen C, et al. Asian J Androl, 2019 Jul-Aug. PMID 30198493, Free PMC Article
  2. A mouse homologue of Strawberry Notch is transcriptionally regulated by Reelin signal. Baba K, et al. Biochem Biophys Res Commun, 2006 Dec 1. PMID 17045962
  3. A mouse-specific retrotransposon drives a conserved Cdk2ap1 isoform essential for development. Modzelewski AJ, et al. Cell, 2021 Oct 28. PMID 34644528, Free PMC Article
  4. Notch and Hippo signaling converge on Strawberry Notch 1 (Sbno1) to synergistically activate Cdx2 during specification of the trophectoderm. Watanabe Y, et al. Sci Rep, 2017 Apr 12. PMID 28401892, Free PMC Article
  5. The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta. Jerome-Majewska LA, et al. Dev Biol, 2010 May 1. PMID 20178780, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC28589

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein strawberry notch homolog 1
Names
sno, strawberry notch homolog 1
strawberry notch homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081203.2 → NP_001074672.1  protein strawberry notch homolog 1 isoform a

    See identical proteins and their annotated locations for NP_001074672.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC127339
    Consensus CDS
    CCDS39280.1
    UniProtKB/Swiss-Prot
    Q3KQK3, Q689Z5, Q8BVN5
    UniProtKB/TrEMBL
    B2RRI2
    Related
    ENSMUSP00000066808.6, ENSMUST00000065263.12
    Conserved Domains (2) summary
    pfam13871
    Location:870 → 1146
    Helicase_C_4; C-terminal domain on Strawberry notch homolog
    pfam13872
    Location:257 → 559
    AAA_34; P-loop containing NTP hydrolase pore-1

  2. NM_001359978.1 → NP_001346907.1  protein strawberry notch homolog 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC127339
    Consensus CDS
    CCDS39280.1
    UniProtKB/Swiss-Prot
    Q3KQK3, Q689Z5, Q8BVN5
    UniProtKB/TrEMBL
    B2RRI2
    Related
    ENSMUSP00000142481.2, ENSMUST00000199808.5
    Conserved Domains (2) summary
    pfam13871
    Location:870 → 1146
    Helicase_C_4; C-terminal domain on Strawberry notch homolog
    pfam13872
    Location:257 → 559
    AAA_34; P-loop containing NTP hydrolase pore-1

  3. NM_001359979.1 → NP_001346908.1  protein strawberry notch homolog 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a.
    Source sequence(s)
    AC127339
    UniProtKB/Swiss-Prot
    Q3KQK3, Q689Z5, Q8BVN5
    UniProtKB/TrEMBL
    F7CVW0
    Conserved Domains (2) summary
    pfam13871
    Location:869 → 1145
    Helicase_C_4; C-terminal domain on Strawberry notch homolog
    pfam13872
    Location:256 → 558
    AAA_34; P-loop containing NTP hydrolase pore-1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    124506765..124564059 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165129.1 → XP_036021022.1  protein strawberry notch homolog 1 isoform X2

    UniProtKB/Swiss-Prot
    Q3KQK3, Q689Z5, Q8BVN5
    UniProtKB/TrEMBL
    F7CVW0
    Related
    ENSMUSP00000130860.3, ENSMUST00000168651.6
    Conserved Domains (2) summary
    pfam13871
    Location:869 → 1145
    Helicase_C_4; C-terminal domain on Strawberry notch homolog
    pfam13872
    Location:256 → 558
    AAA_34; P-loop containing NTP hydrolase pore-1

  2. XM_006530320.5 → XP_006530383.1  protein strawberry notch homolog 1 isoform X3

    See identical proteins and their annotated locations for XP_006530383.1

    UniProtKB/Swiss-Prot
    Q3KQK3, Q689Z5, Q8BVN5
    Conserved Domains (2) summary
    pfam13871
    Location:835 → 1111
    Helicase_C_4; C-terminal domain on Strawberry notch homolog
    pfam13872
    Location:222 → 524
    AAA_34; P-loop containing NTP hydrolase pore-1

  3. XM_006530321.4 → XP_006530384.1  protein strawberry notch homolog 1 isoform X3

    See identical proteins and their annotated locations for XP_006530384.1

    UniProtKB/Swiss-Prot
    Q3KQK3, Q689Z5, Q8BVN5
    Conserved Domains (2) summary
    pfam13871
    Location:835 → 1111
    Helicase_C_4; C-terminal domain on Strawberry notch homolog
    pfam13872
    Location:222 → 524
    AAA_34; P-loop containing NTP hydrolase pore-1

  4. XM_006530323.4 → XP_006530386.1  protein strawberry notch homolog 1 isoform X4

    See identical proteins and their annotated locations for XP_006530386.1

    UniProtKB/Swiss-Prot
    Q3KQK3, Q689Z5, Q8BVN5
    Conserved Domains (2) summary
    pfam13871
    Location:834 → 1110
    Helicase_C_4; C-terminal domain on Strawberry notch homolog
    pfam13872
    Location:221 → 523
    AAA_34; P-loop containing NTP hydrolase pore-1

  5. XM_006530322.5 → XP_006530385.1  protein strawberry notch homolog 1 isoform X4

    See identical proteins and their annotated locations for XP_006530385.1

    UniProtKB/Swiss-Prot
    Q3KQK3, Q689Z5, Q8BVN5
    Conserved Domains (2) summary
    pfam13871
    Location:834 → 1110
    Helicase_C_4; C-terminal domain on Strawberry notch homolog
    pfam13872
    Location:221 → 523
    AAA_34; P-loop containing NTP hydrolase pore-1

  6. XM_036165130.1 → XP_036021023.1  protein strawberry notch homolog 1 isoform X2

    UniProtKB/Swiss-Prot
    Q3KQK3, Q689Z5, Q8BVN5
    UniProtKB/TrEMBL
    F7CVW0
    Conserved Domains (2) summary
    pfam13871
    Location:869 → 1145
    Helicase_C_4; C-terminal domain on Strawberry notch homolog
    pfam13872
    Location:256 → 558
    AAA_34; P-loop containing NTP hydrolase pore-1

  7. XM_006530318.4 → XP_006530381.1  protein strawberry notch homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006530381.1

    UniProtKB/Swiss-Prot
    Q3KQK3, Q689Z5, Q8BVN5
    UniProtKB/TrEMBL
    B2RRI2
    Conserved Domains (2) summary
    pfam13871
    Location:870 → 1146
    Helicase_C_4; C-terminal domain on Strawberry notch homolog
    pfam13872
    Location:257 → 559
    AAA_34; P-loop containing NTP hydrolase pore-1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145631.1: Suppressed sequence

    Description
    NM_145631.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q689Z5.2 GenPept UniProtKB/Swiss-Prot:Q689Z5

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